Changes in Phenotypic and Molecular Features of Naïve and Central Memory T Helper Cell Subsets following SARS-CoV-2 Vaccination.

CD4+ T helper cell COVID-19 SARS-CoV-2 T cell receptor epigenetics repertoire transcriptomics vaccination

Journal

Vaccines
ISSN: 2076-393X
Titre abrégé: Vaccines (Basel)
Pays: Switzerland
ID NLM: 101629355

Informations de publication

Date de publication:
11 Sep 2024
Historique:
received: 01 08 2024
revised: 02 09 2024
accepted: 03 09 2024
medline: 28 9 2024
pubmed: 28 9 2024
entrez: 28 9 2024
Statut: epublish

Résumé

Molecular changes in lymphocytes following SARS-CoV-2 vaccination are incompletely understood. We hypothesized that studying the molecular (transcriptomic, epigenetic, and T cell receptor (TCR) repertoire) changes in CD4

Identifiants

pubmed: 39340069
pii: vaccines12091040
doi: 10.3390/vaccines12091040
pii:
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : NIH HHS
ID : COV19-RECPLAS
Pays : United States
Organisme : National Institute of Academic Anesthesia BJA/RCoA fellowship
ID : WKRO-2018-0047
Organisme : Marshall Scholarship and Clarendon Fund
ID : Marshall Scholarship and Clarendon Fund
Organisme : National Institute for Health Research
ID : 2016-16-011

Auteurs

Mia Mosavie (M)

Centre for Inflammation Research, Institute of Regeneration and Repair, University of Edinburgh, 4-5 Little France Drive, Edinburgh EH16 4UU, UK.

Jennifer Rynne (J)

Centre for Inflammation Research, Institute of Regeneration and Repair, University of Edinburgh, 4-5 Little France Drive, Edinburgh EH16 4UU, UK.

Matthew Fish (M)

Center for Bacterial Pathogenesis, Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA 02114, USA.

Peter Smith (P)

Centre for Inflammation Research, Institute of Regeneration and Repair, University of Edinburgh, 4-5 Little France Drive, Edinburgh EH16 4UU, UK.

Aislinn Jennings (A)

Centre for Inflammation Research, Institute of Regeneration and Repair, University of Edinburgh, 4-5 Little France Drive, Edinburgh EH16 4UU, UK.

Shivani Singh (S)

Department of Medicine, Charing Cross Hospital, Imperial College Healthcare NHS Trust, London W6 8RF, UK.

Jonathan Millar (J)

Centre for Inflammation Research, Institute of Regeneration and Repair, University of Edinburgh, 4-5 Little France Drive, Edinburgh EH16 4UU, UK.

Heli Harvala (H)

Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DU, UK.
Microbiology Services, Colindale, NHS Blood and Transplant, Colindale NW9 5BG, UK.

Ana Mora (A)

Heart Lung Research Institute Clinical Research Facility, Cambridge CB2 0BB, UK.

Fotini Kaloyirou (F)

Statistics and Clinical Research, NHS Blood and Transplant, Cambridge CB2 0PT, UK.

Alexandra Griffiths (A)

Statistics and Clinical Research, NHS Blood and Transplant, Bristol BS34 7QH, UK.

Valerie Hopkins (V)

Statistics and Clinical Research, NHS Blood and Transplant, Cambridge CB2 0PT, UK.

Charlotte Washington (C)

Donor Medicine, NHS Blood and Transplant, Birmingham B15 2SG, UK.

Lise J Estcourt (LJ)

Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DU, UK.

David Roberts (D)

Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DU, UK.

Manu Shankar-Hari (M)

Centre for Inflammation Research, Institute of Regeneration and Repair, University of Edinburgh, 4-5 Little France Drive, Edinburgh EH16 4UU, UK.
Department of Critical Care Medicine, Royal Infirmary of Edinburgh, Edinburgh EH16 4SA, UK.

Classifications MeSH