Vaccine Potency and Structure of Yeast-Produced Polio Type 2 Stabilized Virus-like Particles.

cryo-EM structure immunogenicity neutralizing antibody poliovirus virus-like particle

Journal

Vaccines
ISSN: 2076-393X
Titre abrégé: Vaccines (Basel)
Pays: Switzerland
ID NLM: 101629355

Informations de publication

Date de publication:
20 Sep 2024
Historique:
received: 12 08 2024
revised: 11 09 2024
accepted: 15 09 2024
medline: 28 9 2024
pubmed: 28 9 2024
entrez: 28 9 2024
Statut: epublish

Résumé

Poliovirus (PV) is on the brink of eradication due to global vaccination programs utilizing live-attenuated oral and inactivated polio vaccines. Recombinant PV virus-like particles (VLPs) are emerging as a safe next-generation vaccine candidate for the impending polio-free era. In this study, we investigate the production, antigenicity, thermostability, immunogenicity, and structures of VLPs derived from PV serotype 2 (PV2) wildtype strain and thermally stabilized mutant (wtVLP and sVLP, respectively). Both PV2 wtVLP and sVLP are efficiently produced in

Identifiants

DOI: 10.3390/vaccines12091077 PMID: 39340107
pubmed: 39340107
pii: vaccines12091077
doi: 10.3390/vaccines12091077
pii:
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : National Natural Science Foundation of China
ID : 32370991

Auteurs

Qin Hong (Q)

Key Laboratory of RNA Innovation, Science and Engineering, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China.
ORCID: 0000-0003-0693-6865

Shuxia Wang (S)

Shanghai Institute of Infectious Disease and Biosecurity, Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), Shanghai Medical College, Fudan University, Shanghai 200032, China.

Xiaoli Wang (X)

Huasong (Shanghai) Biomedical Technology Co., Ltd., Shanghai 201210, China.

Wenyu Han (W)

Huasong (Shanghai) Biomedical Technology Co., Ltd., Shanghai 201210, China.

Tian Chen (T)

Shanghai Institute of Infectious Disease and Biosecurity, Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), Shanghai Medical College, Fudan University, Shanghai 200032, China.
Huasong (Shanghai) Biomedical Technology Co., Ltd., Shanghai 201210, China.

Yan Liu (Y)

Huasong (Shanghai) Biomedical Technology Co., Ltd., Shanghai 201210, China.

Fei Cheng (F)

Huasong (Shanghai) Biomedical Technology Co., Ltd., Shanghai 201210, China.

Song Qin (S)

Huasong (Shanghai) Biomedical Technology Co., Ltd., Shanghai 201210, China.

Shengtao Zhao (S)

Huasong (Shanghai) Biomedical Technology Co., Ltd., Shanghai 201210, China.

Qingwei Liu (Q)

Huasong (Shanghai) Biomedical Technology Co., Ltd., Shanghai 201210, China.

Yao Cong (Y)

Key Laboratory of RNA Innovation, Science and Engineering, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China.
Key Laboratory of Systems Health Science of Zhejiang Province, School of Life Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou 310024, China.

Zhong Huang (Z)

Shanghai Institute of Infectious Disease and Biosecurity, Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), Shanghai Medical College, Fudan University, Shanghai 200032, China.
ORCID: 0000-0002-2161-1359

Classifications MeSH