Neuroimaging evaluations of olfactory, gustatory, and neurological deficits in patients with long-term sequelae of COVID-19.

Ageusia Anosmia COVID-19 Hyposmia Neuroimaging, olfactory dysfunction

Journal

Brain imaging and behavior
ISSN: 1931-7565
Titre abrégé: Brain Imaging Behav
Pays: United States
ID NLM: 101300405

Informations de publication

Date de publication:
28 Sep 2024
Historique:
accepted: 17 09 2024
medline: 28 9 2024
pubmed: 28 9 2024
entrez: 28 9 2024
Statut: aheadofprint

Résumé

The World Health Organization indicated that around 36 million of patients in the European Region showed long COVID associated with olfactory and gustatory deficits. The precise mechanism underlying long COVID clinical manifestations is still debated. The aim of this study was to evaluate potential correlations between odor threshold, odor discrimination, odor identification, and the activation of specific brain areas in patients after COVID-19. Sixty subjects, 27 patients (15 women and 12 men) with long COVID and a mean age of 40.6 ± 13.4 years, were compared to 33 age-matched healthy controls (20 women and 13 men) with a mean age of 40.5 ± 9.8 years. Our data showed that patients with long COVID symptoms exhibited a significant decrease in odor threshold, odor discrimination, odor identification, and their sum TDI score compared to age-matched healthy controls. In addition, our results indicated significant correlations between odor discrimination and the increased activation in the right hemisphere, in the frontal pole, and in the superior frontal gyrus. This study indicated that the resting-state fMRI in combination with the objective evaluation of olfactory and gustatory function may be useful for the evaluation of patients with long COVID associated with anosmia and hyposmia.

Identifiants

pubmed: 39340624
doi: 10.1007/s11682-024-00936-0
pii: 10.1007/s11682-024-00936-0
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

© 2024. The Author(s).

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Auteurs

Carla Masala (C)

Department of Biomedical Sciences, University of Cagliari, SP8 Cittadella Universitaria Monserrato, Monserrato, Cagliari, 09042, Italy. cmasala@unica.it.

Michele Porcu (M)

Department of Radiology, AOU Cagliari, University of Cagliari, SS 554 km 4.500, Cagliari, 09042, Italy.

Gianni Orofino (G)

Department of Neurology, AOU Cagliari, University of Cagliari, SS 554 km 4.500, Cagliari, 09042, Italy.

Giovanni Defazio (G)

Department of Translational Biomedicine and Neuroscience, University of Bari, Bari, 70121, Italy.

Ilenia Pinna (I)

Department of Biomedical Sciences, University of Cagliari, SP8 Cittadella Universitaria Monserrato, Monserrato, Cagliari, 09042, Italy.

Paolo Solla (P)

Neurological Unit, AOU Sassari, University of Sassari, Viale S. Pietro 10, Sassari, 07100, Italy.

Tommaso Ercoli (T)

Neurological Unit, AOU Sassari, University of Sassari, Viale S. Pietro 10, Sassari, 07100, Italy.

Jasjit S Suri (JS)

Department of ECE, Idaho State University, Pocatello, ID, 83209, USA.
Department of CE, Graphics Era Deemed to be University, Dehradun, 248002, India.
University Center for Research & Development, Chandigarh University, Mohali, India.
Symbiosis Institute of TechnologySymbiosis International (Deemed University), Nagpur Campus, Pune, India.
Stroke Diagnostic and Monitoring Division, AtheroPoint™, Roseville, CA, 95661, USA.

Giacomo Spinato (G)

Department of Neurosciences, Otolaryngology Unit, University of Padova, Padova, 35100, Italy.

Luca Saba (L)

Department of Radiology, AOU Cagliari, University of Cagliari, SS 554 km 4.500, Cagliari, 09042, Italy.

Classifications MeSH