Optimal combination of microcoils, flow control, and n-butyl cyanoacrylate-Lipiodol-iopamidol (2:3:1) for feasible embolization of medium-sized arteries in an in vitro vascular model.
Embolization
Flow control
Medium-sized arteries
Microcoils
N-butyl cyanoacrylate–Lipiodol–iopamidol
Journal
Japanese journal of radiology
ISSN: 1867-108X
Titre abrégé: Jpn J Radiol
Pays: Japan
ID NLM: 101490689
Informations de publication
Date de publication:
28 Sep 2024
28 Sep 2024
Historique:
received:
05
07
2024
accepted:
19
09
2024
medline:
28
9
2024
pubmed:
28
9
2024
entrez:
28
9
2024
Statut:
aheadofprint
Résumé
To evaluate the behavior of n-butyl cyanoacrylate-Lipiodol-iopamidol at a ratio of 2:3:1 (NLI231) with and without microcoils and/or flow control in embolization of medium-sized arteries in an in vitro vascular model. A vessel model representing a common hepatic artery was prepared. Six scenarios were set for embolization, each ran three times: 1) NLI231 injected alone with flow control to 0 ml/min during and up to 5 min after embolization; 2) NLI231 injected into a mesh of microcoil of 5% density with the flow control; 3) NLI231 injected into a microcoil of 10% density with the flow control; 4) NLI231 injected alone without the flow control; 5) NLI231 injected into microcoil of 5% density without the flow control; 6) NLI231 injected into a microcoil of 10% density without the flow control. The microcoils were delivered to the embolization site, and NLI231 was injected. After 1 h of observation, distal filters were collected, and grades of migration (I = none, II = partial, III = almost all-all) were assessed for each scenario. Embolization was achieved in scenarios with NLI231 and microcoils regardless of flow control (p < 0.01). NLI231 did not migrate in scenarios with microcoils and flow control (p < 0.05). NLI231 with microcoils without flow control can embolize the vessel, but partial migration occurred, and the distal distance of the NLI231 complex from the embolization site was longer (p < 0.01). Combining sparse coiling with NLI231 may be feasible but is limited to use when flow control is available, or where distal embolization is permissible to some extent.
Identifiants
pubmed: 39340741
doi: 10.1007/s11604-024-01667-4
pii: 10.1007/s11604-024-01667-4
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2024. The Author(s).
Références
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