LYP regulates SLP76 and other adaptor proteins in T cells.
FYB
LYP (lymphoid phosphatase)
Protein tyrosine phosphatase (PTP)
SKAP2
SLP76
T-cell
T-cell receptor (TCR)
Journal
Biological research
ISSN: 0717-6287
Titre abrégé: Biol Res
Pays: England
ID NLM: 9308271
Informations de publication
Date de publication:
28 Sep 2024
28 Sep 2024
Historique:
received:
30
12
2023
accepted:
06
08
2024
medline:
29
9
2024
pubmed:
29
9
2024
entrez:
28
9
2024
Statut:
epublish
Résumé
The LYP tyrosine phosphatase presents a SNP (1858C > T) that increases the risk of developing autoimmune diseases such as type I diabetes and arthritis. It remains unclear how this SNP affects LYP function and promotes the development of these diseases. The scarce information about LYP substrates is in part responsible for the poor understanding of LYP function. In this study, we identify in T lymphocytes several adaptor proteins as potential substrates targeted by LYP, including FYB, SLP-76, HS-1, Vav, SKAP1 and SKAP2. We also show that LYP co-localizes with SLP76 in microclusters, upon TCR engagement. These data indicate that LYP may modulate T cell activation by dephosphorylating several adaptor proteins, such as FYB, SLP-76, HS-1, Vav, SKAP1 and SKAP2 upon TCR engagement.
Sections du résumé
BACKGROUND
BACKGROUND
The LYP tyrosine phosphatase presents a SNP (1858C > T) that increases the risk of developing autoimmune diseases such as type I diabetes and arthritis. It remains unclear how this SNP affects LYP function and promotes the development of these diseases. The scarce information about LYP substrates is in part responsible for the poor understanding of LYP function.
RESULTS
RESULTS
In this study, we identify in T lymphocytes several adaptor proteins as potential substrates targeted by LYP, including FYB, SLP-76, HS-1, Vav, SKAP1 and SKAP2. We also show that LYP co-localizes with SLP76 in microclusters, upon TCR engagement.
CONCLUSIONS
CONCLUSIONS
These data indicate that LYP may modulate T cell activation by dephosphorylating several adaptor proteins, such as FYB, SLP-76, HS-1, Vav, SKAP1 and SKAP2 upon TCR engagement.
Identifiants
pubmed: 39342392
doi: 10.1186/s40659-024-00536-8
pii: 10.1186/s40659-024-00536-8
doi:
Substances chimiques
Adaptor Proteins, Signal Transducing
0
SLP-76 signal Transducing adaptor proteins
0
Phosphoproteins
0
Receptors, Antigen, T-Cell
0
Protein Tyrosine Phosphatases
EC 3.1.3.48
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
69Subventions
Organisme : Consejería de Sanidad, Junta de Castilla y León
ID : CCVC8485
Organisme : Agencia Estatal de Investigación
ID : MCIN/AEI/10.13039/501100011033
Organisme : Junta de Castilla y León
ID : CLC-2017-01
Informations de copyright
© 2024. The Author(s).
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