The landscape of combining immune checkpoint inhibitors with novel Therapies: Secret alliances against breast cancer.

Breast cancer Immune checkpoints Immune checkpoints blockade Immunotherapy Targeted therapy

Journal

Cancer treatment reviews
ISSN: 1532-1967
Titre abrégé: Cancer Treat Rev
Pays: Netherlands
ID NLM: 7502030

Informations de publication

Date de publication:
24 Sep 2024
Historique:
received: 13 08 2024
revised: 04 09 2024
accepted: 22 09 2024
medline: 30 9 2024
pubmed: 30 9 2024
entrez: 29 9 2024
Statut: aheadofprint

Résumé

This review focuses on the immune checkpoint inhibitors (ICIs) in the context of breast cancer (BC) management. These innovative treatments, by targeting proteins expressed on both tumor and immune cells, aim to overcome tumor-induced immune suppression and reactivate the immune system. The potential of this approach is the subject of numerous clinical studies. Here, we explore the key studies and emerging therapies related to ICIs providing a detailed analysis of their specific and combined use in BC treatment.

Identifiants

DOI: 10.1016/j.ctrv.2024.102831 PMID: 39342797
pubmed: 39342797
pii: S0305-7372(24)00159-2
doi: 10.1016/j.ctrv.2024.102831
pii:
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

102831

Informations de copyright

Copyright © 2024 The Author(s). Published by Elsevier Ltd.. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Auteurs

Federico Rebaudi (F)

Department of Experimental Medicine (DIMES), University of Genoa, Genoa, Italy.

Fabiana De Franco (F)

Department of Experimental Medicine (DIMES), University of Genoa, Genoa, Italy.

Rayan Goda (R)

Department of Experimental Medicine (DIMES), University of Genoa, Genoa, Italy.

Valentina Obino (V)

Department of Experimental Medicine (DIMES), University of Genoa, Genoa, Italy.

Giorgio Vita (G)

Department of Internal Medicine (DIMI), University of Genoa, Genoa, Italy.

Camilla Baronti (C)

Department of Experimental Medicine (DIMES), University of Genoa, Genoa, Italy.

Eleonora Iannone (E)

Breast Surgery Clinic, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.

Francesca Pitto (F)

Department of Pathology, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.

Barbara Massa (B)

Department of Pathology, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.

Daniela Fenoglio (D)

Department of Internal Medicine (DIMI), University of Genoa, Genoa, Italy; Biotherapy Unit, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.

Camilla Jandus (C)

Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, Geneva, Switzerland; Ludwig Institute for Cancer Research, Lausanne Branch, Lausanne, Switzerland; Geneva Center for Inflammation Research, Geneva, Switzerland.

Francesca Poggio (F)

Department of Medical Oncology, Clinica di Oncologia Medica, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.

Piero Fregatti (P)

Breast Surgery Clinic, IRCCS Ospedale Policlinico San Martino, Genoa, Italy; Department of Integrated Surgical and Diagnostic Sciences (DISC), University of Genoa, Genoa, Italy.

Ombretta Melaiu (O)

Department of Clinical Sciences and Translational Medicine, University of Rome "Tor Vergata", Rome, Italy.

Matteo Bozzo (M)

Department of Earth, Environmental and Life Sciences (DISTAV), University of Genoa, Genoa, Italy.

Simona Candiani (S)

Department of Earth, Environmental and Life Sciences (DISTAV), University of Genoa, Genoa, Italy; IRCCS Ospedale Policlinico San Martino, Genoa, Italy.

Federica Papaccio (F)

Department of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", University of Salerno, Baronissi, Italy.

Marco Greppi (M)

Department of Experimental Medicine (DIMES), University of Genoa, Genoa, Italy. Electronic address: marco.greppi@edu.unige.it.

Silvia Pesce (S)

Department of Experimental Medicine (DIMES), University of Genoa, Genoa, Italy; IRCCS Ospedale Policlinico San Martino, Genoa, Italy. Electronic address: silvia.pesce@unige.it.

Emanuela Marcenaro (E)

Department of Experimental Medicine (DIMES), University of Genoa, Genoa, Italy; IRCCS Ospedale Policlinico San Martino, Genoa, Italy. Electronic address: emanuela.marcenaro@unige.it.

Classifications MeSH