Intradermal and transdermal absorption of beta-naphthylamine and n-phenyl-beta-naphthylamine in a viable human skin model.
Dermal depot
Intradermal penetration
N-phenyl-beta-naphthylamine
Transdermal absorption
Viable skin
beta-naphthylamine
Journal
Toxicology in vitro : an international journal published in association with BIBRA
ISSN: 1879-3177
Titre abrégé: Toxicol In Vitro
Pays: England
ID NLM: 8712158
Informations de publication
Date de publication:
27 Sep 2024
27 Sep 2024
Historique:
received:
20
06
2024
revised:
08
09
2024
accepted:
26
09
2024
medline:
30
9
2024
pubmed:
30
9
2024
entrez:
29
9
2024
Statut:
aheadofprint
Résumé
Technical products containing n-phenyl-beta-naphthylamine (PBNA) are contaminated with beta-naphthylamine (BNA), a known carcinogen. Both amines penetrate the skin to different degrees, but little is known about their dermal-depot formation. This study investigated the dermal penetration of PBNA and its degradation product BNA using a viable human-skin model. PBNA (259 μg) or BNA (0.52 μg) in n-hexane and industrial grease were applied to freshly excised human skin (n = 6, 0.64 cm
Identifiants
pubmed: 39343073
pii: S0887-2333(24)00177-2
doi: 10.1016/j.tiv.2024.105947
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
105947Informations de copyright
Copyright © 2024. Published by Elsevier Ltd.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare that they have no conflict of interest.