The influence of growth rate-controlling feeding strategy on the surfactin production in Bacillus subtilis bioreactor processes.
Bacillus subtilis
Bioprocess engineering
Bioreactor
Fed-batch
Surfactin
Journal
Microbial cell factories
ISSN: 1475-2859
Titre abrégé: Microb Cell Fact
Pays: England
ID NLM: 101139812
Informations de publication
Date de publication:
30 Sep 2024
30 Sep 2024
Historique:
received:
24
06
2024
accepted:
16
09
2024
medline:
30
9
2024
pubmed:
30
9
2024
entrez:
29
9
2024
Statut:
epublish
Résumé
The production of surfactin, an extracellular accumulating lipopeptide produced by various Bacillus species, is a well-known representative of microbial biosurfactant. However, only limited information is available on the correlation between the growth rate of the production strain, such as B. subtilis BMV9, and surfactin production. To understand the correlation between biomass formation over time and surfactin production, the availability of glucose as carbon source was considered as main point. In fed-batch bioreactor processes, the B. subtilis BMV9 was used, a strain well-suited for high cell density fermentation. By adjusting the exponential feeding rates, the growth rate of the surfactin-producing strain, was controlled. Using different growth rates in the range of 0.075 and 0.4 h Overall, the parameter of adjusting exponential feeding rates have an important impact on the B. subtilis productivity in terms of surfactin production in fed-batch bioreactor processes. A growth rate of 0.25 h
Sections du résumé
BACKGROUND
BACKGROUND
The production of surfactin, an extracellular accumulating lipopeptide produced by various Bacillus species, is a well-known representative of microbial biosurfactant. However, only limited information is available on the correlation between the growth rate of the production strain, such as B. subtilis BMV9, and surfactin production. To understand the correlation between biomass formation over time and surfactin production, the availability of glucose as carbon source was considered as main point. In fed-batch bioreactor processes, the B. subtilis BMV9 was used, a strain well-suited for high cell density fermentation. By adjusting the exponential feeding rates, the growth rate of the surfactin-producing strain, was controlled.
RESULTS
RESULTS
Using different growth rates in the range of 0.075 and 0.4 h
CONCLUSIONS
CONCLUSIONS
Overall, the parameter of adjusting exponential feeding rates have an important impact on the B. subtilis productivity in terms of surfactin production in fed-batch bioreactor processes. A growth rate of 0.25 h
Identifiants
pubmed: 39343903
doi: 10.1186/s12934-024-02531-w
pii: 10.1186/s12934-024-02531-w
doi:
Substances chimiques
Lipopeptides
0
Glucose
IY9XDZ35W2
Peptides, Cyclic
0
Surface-Active Agents
0
surfactin peptide
24730-31-2
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
260Informations de copyright
© 2024. The Author(s).
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