Cholinergic Signaling Mediated by Muscarinic Receptors Triggers the Ultraviolet-Induced Release of Melanosome in Cultured Melanoma Cells.
acetylcholine
bethanechol
melanoma
melanosomes
skin pigmentation
Journal
Pigment cell & melanoma research
ISSN: 1755-148X
Titre abrégé: Pigment Cell Melanoma Res
Pays: England
ID NLM: 101318927
Informations de publication
Date de publication:
30 Sep 2024
30 Sep 2024
Historique:
revised:
01
09
2024
received:
15
02
2024
accepted:
09
09
2024
medline:
30
9
2024
pubmed:
30
9
2024
entrez:
30
9
2024
Statut:
aheadofprint
Résumé
In skin, melanin is synthesized and stored in melanosomes. In epidermal melanocytes, melanosomes are transported to and internalized by the neighboring keratinocytes, subsequently leading to skin pigmentation. Ultraviolet (UV) radiation induces the release of acetylcholine (ACh) from keratinocytes, which in turn activates ACh receptors (AChRs) on nearby melanocytes, forming a proposed "skin synapse". Here, we illustrated that the UV-induced melanosome release from cultured B16F10 melanoma cells could be mediated by co-actions of ACh. In the cell cultures, UV exposure robustly elicited melanosome release. Applied bethanechol (BeCh), an agonist of muscarinic AChR (mAChR), could significantly enhance the release. In parallel, the intracellular Ca
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Hong Kong Research Grants Council
Organisme : Zhongshan Municipal Bureau of Science and Technology
Organisme : Guangzhou Science and Technology Committee Research Grant
Organisme : GBA Institute of Collaborate Innovation
Organisme : The Key-Area Research and Development Program for Guangdong Province
Organisme : Special project of Foshan University of Science and Techonology in 2019
Organisme : Hong Kong RGC Theme-based Research Scheme
Organisme : Hong Kong Innovation Technology Fund
Organisme : Shenzhen Science and Technology Innovation Committee
Informations de copyright
© 2024 The Author(s). Pigment Cell & Melanoma Research published by John Wiley & Sons Ltd.
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