Supramolecular Architectures of Dendritic Polymers Provide Irreversible Inhibitor to Block Viral Infection.

SARS‐CoV‐2 dendritic polymer supramolecular structures virucidal virus inhibition

Journal

Advanced materials (Deerfield Beach, Fla.)
ISSN: 1521-4095
Titre abrégé: Adv Mater
Pays: Germany
ID NLM: 9885358

Informations de publication

Date de publication:
30 Sep 2024
Historique:
revised: 20 09 2024
received: 11 06 2024
medline: 30 9 2024
pubmed: 30 9 2024
entrez: 30 9 2024
Statut: aheadofprint

Résumé

In Nature, most known objects can perform their functions only when in supramolecular self-assembled from, e.g. protein complexes and cell membranes. Here, a dendritic polymer is presented that inhibits severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with an irreversible (virucidal) mechanism only when self-assembled into a Two-dimmensional supramolecular polymer (2D-SupraPol). Monomeric analogs of the dendritic polymer can only inhibit SARS-CoV-2 reversibly, thus allowing for the virus to regain infectivity after dilution. Upon assembly, 2D-SupraPol shows a remarkable half-inhibitory concentration (IC

Identifiants

pubmed: 39344918
doi: 10.1002/adma.202408294
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

e2408294

Subventions

Organisme : European Research Council
Pays : International
Organisme : Deutsche Forschungsgemeinschaft
ID : BioSupraMol

Informations de copyright

© 2024 The Author(s). Advanced Materials published by Wiley‐VCH GmbH.

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Auteurs

Ehsan Mohammadifar (E)

Institut für Chemie und Biochemie Freie Universität Berlin, Takustr 3, 14195, Berlin, Germany.

Matteo Gasbarri (M)

Institute of Materials, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, 1015, Switzerland.

Mathias Dimde (M)

Forschungszentrum für Elektronenmikroskopie und Gerätezentrum BioSupraMol, Institut für Chemie und Biochemie, Freie Universität Berlin, Berlin, Germany.

Chuanxiong Nie (C)

Institut für Chemie und Biochemie Freie Universität Berlin, Takustr 3, 14195, Berlin, Germany.

Heyun Wang (H)

Institute of Materials, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, 1015, Switzerland.

Tatyana L Povolotsky (TL)

Institut für Chemie und Biochemie Freie Universität Berlin, Takustr 3, 14195, Berlin, Germany.

Yannic Kerkhoff (Y)

Forschungszentrum für Elektronenmikroskopie und Gerätezentrum BioSupraMol, Institut für Chemie und Biochemie, Freie Universität Berlin, Berlin, Germany.

Daniel Desmecht (D)

Animal Pathology, FARAH Research Center, Faculty of Veterinary Medicine, University of Liège, Sart-Tilman B43, Liège, 4000, Belgium.

Sylvain Prevost (S)

Institut Laue-Langevin - The European Neutron Source, 71 avenue des Martyrs - CS 20156 38042, Grenoble, cedex 9, France.

Thomas Zemb (T)

ICSM, CEA, CNRS, ENSCM, Univ Montpellier, Bagnols-sur-Ceze, 30207, France.

Kai Ludwig (K)

Forschungszentrum für Elektronenmikroskopie und Gerätezentrum BioSupraMol, Institut für Chemie und Biochemie, Freie Universität Berlin, Berlin, Germany.

Francesco Stellacci (F)

Institute of Materials, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, 1015, Switzerland.

Rainer Haag (R)

Institut für Chemie und Biochemie Freie Universität Berlin, Takustr 3, 14195, Berlin, Germany.

Classifications MeSH