5,10,15,20-Tetrakis(4-sulfonatophenyl)porphyrin Zinc and Chloro-aluminum Phthalocyanine Disulfonate in Photodynamic Therapy of Colorectal Adenocarcinoma
Humans
Photochemotherapy
/ methods
Colorectal Neoplasms
/ drug therapy
Photosensitizing Agents
/ pharmacology
Indoles
/ pharmacology
Reactive Oxygen Species
/ metabolism
Organometallic Compounds
/ pharmacology
Metalloporphyrins
/ pharmacology
Adenocarcinoma
/ drug therapy
HT29 Cells
Cell Survival
/ drug effects
DNA Damage
/ drug effects
Colorectal adenocarcinoma
DNA fragmentation
photodynamic therapy
phthalocyanines
porphyrins
reactive oxygen species
Journal
Anticancer research
ISSN: 1791-7530
Titre abrégé: Anticancer Res
Pays: Greece
ID NLM: 8102988
Informations de publication
Date de publication:
Oct 2024
Oct 2024
Historique:
received:
12
08
2024
revised:
02
09
2024
accepted:
03
09
2024
medline:
1
10
2024
pubmed:
1
10
2024
entrez:
30
9
2024
Statut:
ppublish
Résumé
Colorectal cancer (CRC) is one of the most widespread malignancies. One of the alternative therapeutic methods appears to be photodynamic therapy (PDT). This study investigated the efficiency of 5,10,15,20-tetrakis(4-sulfonatophenyl)porphyrin zinc (ZnTPPS All photosensitizers showed good accumulation within HT29 cells, high efficiency in killing the cells, and a concentration-dependent increase in the production of ROS. PDT using ZnTPPS
Sections du résumé
BACKGROUND/AIM
OBJECTIVE
Colorectal cancer (CRC) is one of the most widespread malignancies. One of the alternative therapeutic methods appears to be photodynamic therapy (PDT).
MATERIALS AND METHODS
METHODS
This study investigated the efficiency of 5,10,15,20-tetrakis(4-sulfonatophenyl)porphyrin zinc (ZnTPPS
RESULTS
RESULTS
All photosensitizers showed good accumulation within HT29 cells, high efficiency in killing the cells, and a concentration-dependent increase in the production of ROS.
CONCLUSION
CONCLUSIONS
PDT using ZnTPPS
Identifiants
pubmed: 39348959
pii: 44/10/4339
doi: 10.21873/anticanres.17263
doi:
Substances chimiques
Photosensitizing Agents
0
Indoles
0
Reactive Oxygen Species
0
Organometallic Compounds
0
Metalloporphyrins
0
zinc-tetrakis(p-sulfonatophenyl)porphyrin
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
4339-4346Informations de copyright
Copyright © 2024 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.