Manometric Intraocular Pressure Reduction with Negative Pressure Using Ocular Pressure Adjusting Pump Goggles.

The Ocular Pressure Adjusting Pump is a novel, non-invasive and non-pharmacological intraocular pressure (IOP)-lowering device consisting of goggles attached to a negative pressure (NP) pump. This study aimed to determine the effect of negative pressure in Ocular Pressure Adjusting Pump goggles on IOP using continuous direct manometry. Prospective, single-arm, single center, basic physiological research trial. Adult patients undergoing cataract surgery. Direct manometry was performed via an anterior chamber cannula attached to an IOP sensor. This was placed just prior to each subject's previously scheduled cataract surgery. IOP was continuously monitored every 0.5 seconds through the following sequence of 30 seconds each: baseline IOP measurement, NP -10 mmHg, NP off, NP -20 mmHg, and NP off. IOP response to application of negative pressure. All seventeen subjects had a dose-dependent reduction in IOP, with a mean IOP decrease from 16.9 to 11.3 (33%) with -10 mmHg of NP and from 15.7 to 7.7 (51%) mmHg with -20 mmHg of NP. IOP returned to baseline for each cycle when NP was discontinued. There were no patients with increased IOP. Negative pressure with the Ocular Pressure Adjusting Pump results in a consistent dose-dependent reduction in IOP, with return to baseline IOP when NP is discontinued.

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