Chronic myelomonocytic leukemia with NPM1 mutation or acute myeloid leukemia?
NPM1
NPM1 CMML
NPM1mut CMML
AML
CMML
CMML treatment
acute myeloid leukemia
chronic myelomonocytic leukemia
Journal
The oncologist
ISSN: 1549-490X
Titre abrégé: Oncologist
Pays: England
ID NLM: 9607837
Informations de publication
Date de publication:
30 Sep 2024
30 Sep 2024
Historique:
received:
09
12
2023
accepted:
20
04
2024
medline:
1
10
2024
pubmed:
1
10
2024
entrez:
30
9
2024
Statut:
aheadofprint
Résumé
The 2022 WHO revision and the ICC classification have recently modified the diagnostic criteria for chronic myelomonocytic leukemia (CMML) and acute myeloid leukemia. However, there is no consensus on whether CMML with NPM1 mutation (NPM1mut) should be diagnosed as AML. Nowadays, it is a subject of discussion because of its diagnostic and therapeutic implications. Therefore, we describe a case of a patient diagnosed with CMML NPM1mut and briefly review the literature to highlight the uncertainty about how to classify a CMML with NPM1 mutation. We emphasize the importance of a comprehensive molecular study, which is crucial to optimize the individualized treatment of patients, enabling them to access targeted therapies.
Identifiants
pubmed: 39349391
pii: 7797258
doi: 10.1093/oncolo/oyae246
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Instituto de Salud Carlos III (ISCIII)
ID : FIS PI19/01476
Organisme : Spanish Ministry of Education (VTM)
Informations de copyright
© The Author(s) 2024. Published by Oxford University Press.