Preventing bacterial adhesion to skin by altering their physicochemical cell surface properties specifically.


Journal

NPJ biofilms and microbiomes
ISSN: 2055-5008
Titre abrégé: NPJ Biofilms Microbiomes
Pays: United States
ID NLM: 101666944

Informations de publication

Date de publication:
30 Sep 2024
Historique:
received: 16 04 2024
accepted: 15 09 2024
medline: 1 10 2024
pubmed: 1 10 2024
entrez: 30 9 2024
Statut: epublish

Résumé

The adhesion of bacteria to surfaces is associated with physicochemical and biological interactions. The present investigations provide new results about the differential adhesion levels of skin bacteria using a representative 3D skin model which mainly relies on the different physicochemical properties of the respective surfaces. Modulation of the adhesion of bacteria and thus their colonization, may occur by adjusting the physicochemical properties of the epidermal and bacterial surfaces. Lewis acid and hydrophobicity were the most strongly correlated parameters with the antiadhesion properties of the tested compounds. Modulation of physicochemical properties appears to be the primary driver of reduced Staphylococcus aureus adhesion in this study, with no significant changes observed in the expression of genes associated with classical adhesion pathways.

Identifiants

pubmed: 39349508
doi: 10.1038/s41522-024-00568-8
pii: 10.1038/s41522-024-00568-8
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

94

Informations de copyright

© 2024. The Author(s).

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Auteurs

Xavier Janvier (X)

L'Oréal Research & Innovation, Chevilly-Larue, France.

Severine Jansen (S)

L'Oréal Research & Innovation, Chevilly-Larue, France.

Charleyne Prenom (C)

L'Oréal Research & Innovation, Chevilly-Larue, France.

Nabiha Khodabux (N)

L'Oréal Research & Innovation, Chevilly-Larue, France.

Francesca Zuttion (F)

L'Oréal Research & Innovation, Aulnay-sous-Bois, France.

Cécile Duclairoir-Poc (C)

Bacterial Communication and Anti-infectious Strategies (CBSA), UR4312, Rouen-Normandy University, Evreux, France.

Sylvie Cupferman (S)

L'Oréal Research & Innovation, Chevilly-Larue, France.

Ahmad Khodr (A)

L'Oréal Research & Innovation, Chevilly-Larue, France. ahmad.khodr@loreal.com.

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