Association of maternal blood mercury concentration during the first trimester of pregnancy with birth outcomes.

Humans Pregnancy Female Mercury / blood Adult Premature Birth / blood Case-Control Studies Pregnancy Outcome Pregnancy Trimester, First / blood Birth Weight / drug effects Maternal Exposure / adverse effects Infant, Newborn China
Low birth weight, Mercury exposure Maternal blood mercury concentration Spontaneous preterm birth

Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
30 Sep 2024
Historique:
received: 25 07 2024
accepted: 25 09 2024
medline: 1 10 2024
pubmed: 1 10 2024
entrez: 30 9 2024
Statut: epublish

Résumé

Exposure to mercury has been associated with adverse effects on pregnancy outcomes. However, there is limited literature on mercury exposure and pregnancy outcomes in Chinese pregnant women. Our study was to investigate the possible association between maternal mercury exposure and spontaneous preterm birth and birth weight. This study was a nested case-control study. The association between blood mercury concentration and both spontaneous preterm birth and birth weight was analyzed using conditional logistic regression and linear regression adjusted for the potential confounding factors, respectively. The dose-response relationship between mercury concentration and birth outcomes was estimated using restricted cubic spline regression. The mean concentration of mercury was 2.8 ± 2.2 µg/L. A positive relationship was observed between maternal blood mercury concentration and SPB when analyzed as a continuous variable. However, it was not found to be statistically significant (adjusted OR = 1.10, 95% CI = 0.95-1.26, P = 0.202). Moderate mercury exposure was associated with a higher risk of SPB (Q3 vs. Q1: crude OR = 2.50, 95% CI = 1.16-5.41, P = 0.02; adjusted OR = 3.49, 95% CI = 1.33-9.11, P = 0.011). After considering the combined effects of chemicals other than mercury exposure (including lead, selenium, and cadmium), the results remained consistent. There was no statistically significant association between blood mercury levels and birth weight (adjusted coefficient = 18.64, P-value = 0.075). There were no statistically significant dose-response associations between mercury concentration and birth outcomes (SPB: P = 0.076; birth weight: P = 0.885). Public health policies should focus on reducing environmental releases of mercury, improving food safety standards, and providing education to pregnant women about the risks of mercury exposure and preventive measures.

Identifiants

DOI: 10.1038/s41598-024-74373-w PMID: 39349681
pubmed: 39349681
doi: 10.1038/s41598-024-74373-w
pii: 10.1038/s41598-024-74373-w
doi:

Substances chimiques

Mercury FXS1BY2PGL

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

22675

Subventions

Organisme : Natural Science Foundation of Fujian Province of China for Youths
ID : No.2021J05081
Organisme : Joint Funds for the innovation of science and Technology, Fujian province
ID : No.2023Y9388
Organisme : Key Project on the integration of Industry, Education and Research Collaborative Innovation of Fujian Province
ID : No.2021YZ034011
Organisme : Key Project on Science and Technology Program of Fujian Health Commission
ID : No.2021ZD01002

Informations de copyright

© 2024. The Author(s).

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Auteurs

Wei Li (W)

Division of Birth Cohort Study, Fujian Obstetrics and Gynecology Hospital, Fuzhou, Fujian, China.
Division of Birth Cohort Study, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, 350001, Fujian, China.

Chong Miao (C)

Department of Information Technology, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, Fujian, China.

Bin Sun (B)

Division of Birth Cohort Study, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, 350001, Fujian, China.

Zhengqin Wu (Z)

Division of Birth Cohort Study, Fujian Obstetrics and Gynecology Hospital, Fuzhou, Fujian, China.
Division of Birth Cohort Study, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, 350001, Fujian, China.

Xinrui Wang (X)

Medical Research Center, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, China.

Haibo Li (H)

Division of Birth Cohort Study, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, 350001, Fujian, China.

Haiyan Gao (H)

Division of Birth Cohort Study, Fujian Obstetrics and Gynecology Hospital, Fuzhou, Fujian, China.
Division of Birth Cohort Study, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, 350001, Fujian, China.

Yibing Zhu (Y)

Division of Birth Cohort Study, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, 350001, Fujian, China. zybfmc@163.com.
Fujian Key Laboratory of Women and Children's Critical Disease Research, Fuzhou, Fujian, China. zybfmc@163.com.

Hua Cao (H)

Fujian Key Laboratory of Women and Children's Critical Disease Research, Fuzhou, Fujian, China. Ch_1213@126.com.

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questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Association of maternal blood mercury...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Grossesse › Association of maternal blood mercury...
questionsmedicales.fr › Produits chimiques inorganiques › Métaux › Métaux lourds › Mercure › Association of maternal blood mercury...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Association of maternal blood mercury...
questionsmedicales.fr › Maladies urogénitales › Maladies de l'appareil urogénital féminin et complications de la grossesse › Complications de la grossesse › Complications du travail obstétrical › Travail obstétrical prématuré › Naissance prématurée › Association of maternal blood mercury...
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questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Grossesse › Issue de la grossesse › Association of maternal blood mercury...
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