The role and regulation of integrins in cell migration and invasion.


Journal

Nature reviews. Molecular cell biology
ISSN: 1471-0080
Titre abrégé: Nat Rev Mol Cell Biol
Pays: England
ID NLM: 100962782

Informations de publication

Date de publication:
30 Sep 2024
Historique:
accepted: 23 08 2024
medline: 1 10 2024
pubmed: 1 10 2024
entrez: 30 9 2024
Statut: aheadofprint

Résumé

Integrin receptors are the main molecular link between cells and the extracellular matrix (ECM) as well as mediating cell-cell interactions. Integrin-ECM binding triggers the formation of heterogeneous multi-protein assemblies termed integrin adhesion complexes (IACs) that enable integrins to transform extracellular cues into intracellular signals that affect many cellular processes, especially cell motility. Cell migration is essential for diverse physiological and pathological processes and is dysregulated in cancer to favour cell invasion and metastasis. Here, we discuss recent findings on the role of integrins in cell migration with a focus on cancer cell dissemination. We review how integrins regulate the spatial distribution and dynamics of different IACs, covering classical focal adhesions, emerging adhesion types and adhesion regulation. We discuss the diverse roles integrins have during cancer progression from cell migration across varied ECM landscapes to breaching barriers such as the basement membrane, and eventual colonization of distant organs.

Identifiants

pubmed: 39349749
doi: 10.1038/s41580-024-00777-1
pii: 10.1038/s41580-024-00777-1
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

© 2024. Springer Nature Limited.

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Auteurs

Megan R Chastney (MR)

Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland.

Jasmin Kaivola (J)

Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland.

Veli-Matti Leppänen (VM)

Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland.

Johanna Ivaska (J)

Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland. joivaska@utu.fi.
Department of Life Technologies, University of Turku, Turku, Finland. joivaska@utu.fi.
InFLAMES Research Flagship Center, University of Turku, Turku, Finland. joivaska@utu.fi.
Western Finnish Cancer Center (FICAN West), University of Turku, Turku, Finland. joivaska@utu.fi.
Foundation for the Finnish Cancer Institute, Helsinki, Finland. joivaska@utu.fi.

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