Differences in structural optical coherence tomography and infrared enface images between non-exudative macular neovascularizations secondary to AMD and pachychoroid disease.
Journal
Eye (London, England)
ISSN: 1476-5454
Titre abrégé: Eye (Lond)
Pays: England
ID NLM: 8703986
Informations de publication
Date de publication:
30 Sep 2024
30 Sep 2024
Historique:
received:
16
10
2023
accepted:
20
09
2024
revised:
14
08
2024
medline:
1
10
2024
pubmed:
1
10
2024
entrez:
30
9
2024
Statut:
aheadofprint
Résumé
To provide an analysis of structural optical coherence tomography (OCT) and enface infrared reflectance (IR) differences between non-exudative macular neovascularizations (NE MNVs) secondary to age-related macular degeneration (AMD) and NE MNVs secondary to pachychoroid spectrum. Patients diagnosed with NE-MNV documented by OCTA and dye angiography in the context of either AMD or pachychoroid spectrum were retrospectively included in AMD group and PACHY group respectively. Only treatment-naïve NE MNVs showing persistence of non-exudative status for at least 1 year after diagnosis were considered. Availability of good quality structural OCT B scan and IR enface acquisitions both at baseline and at 1 year follow up was also required. The study population included 15 eyes of 15 patients in AMD group and 13 eyes of 13 patients in PACHY group. AMD group showed at baseline a significantly wider pigment epithelium detachment (PED) apex angle (p = 0.02), higher homogeneity of the PED (p = 0.015), higher PED shadowing(p = 0.03). Both groups experienced a widening of apex angle (flattening of the PED) during follow-up. Ten (76.9%) patients in PACHY group showed a hyporeflective halo at the margins of the PED at baseline compared to 3/15 (20.0%) patients in AMD group (0.007), with no significant changes at 1 year follow up (p = 0.47). NE-MNVs in pachychoroid eyes are characterized by sharper and more inhomogeneous PEDs with a lighter choroidal shadowing compared to NE-MNVs in AMD eyes. Moreover, they often show a hyporeflective halo around the lesion with IR imaging.
Identifiants
pubmed: 39349754
doi: 10.1038/s41433-024-03374-w
pii: 10.1038/s41433-024-03374-w
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2024. The Author(s), under exclusive licence to The Royal College of Ophthalmologists.
Références
Laiginhas R, Yang J, Rosenfeld PJ, Falcão M. Nonexudative macular neovascularization—a systematic review of prevalence, natural history, and recent insights from OCT angiography. Ophthalmol Retin. 2020;4:651–61.
doi: 10.1016/j.oret.2020.02.016
Querques G, Srour M, Massamba N, Georges A, Ben Moussa N, Rafaeli O, et al. Functional characterization and multimodal imaging of treatment-naïve “quiescent” choroidal neovascularization. Investig Ophthalmol Vis Sci. 2013;54:6886–92.
doi: 10.1167/iovs.13-11665
Sacconi R, Sarraf D, Garrity S, Freund KB, Yannuzzi LA, Gal-Or O, et al. Nascent type 3 neovascularization in age-related macular degeneration. Ophthalmol Retin. 2018;2:1097–106.
doi: 10.1016/j.oret.2018.04.016
Rabiolo A, Carnevali A, Bandello F, Querques G. Optical coherence tomography angiography: evolution or revolution? Expert Rev Ophthalmol. 2016;11:243–5.
doi: 10.1080/17469899.2016.1209409
Carnevali A, Cicinelli MV, Capuano V, Corvi F, Mazzaferro A, Querques L, et al. Optical coherence tomography angiography: a useful tool for diagnosis of treatment-naïve quiescent choroidal neovascularization. Am J Ophthalmol. 2016;169:189–98.
doi: 10.1016/j.ajo.2016.06.042
pubmed: 27394033
Carnevali A, Sacconi R, Querques L, Marchese A, Capuano V, Rabiolo A, et al. Natural history of treatment-naïve quiescent choroidal neovascularization in age-related macular degeneration using OCT angiography. Ophthalmol Retin. 2018;2:922–30.
doi: 10.1016/j.oret.2018.02.002
Dansingani KK, Balaratnasingam C, Klufas MA, Sarraf D, Freund KB. Optical coherence tomography angiography of shallow irregular pigment epithelial detachments in pachychoroid spectrum disease. Am J Ophthalmol. 2015;160:1243–1254.e2.
doi: 10.1016/j.ajo.2015.08.028
pubmed: 26319161
Spaide RF. The ambiguity of pachychoroid. Retina. 2021;41:231.
doi: 10.1097/IAE.0000000000003057
pubmed: 33315817
Shinojima A, Lee D, Tsubota K, Negishi K, Kurihara T. Retinal diseases regulated by hypoxia—basic and clinical perspectives: a comprehensive review. J Clin Med. 2021;10:5496.
doi: 10.3390/jcm10235496
pubmed: 34884197
pmcid: 8658588
Sacconi R, Fragiotta S, Sarraf D, Sadda SR, Freund KB, Parravano M, et al. Towards a better understanding of non-exudative choroidal and macular neovascularization. Prog Retinal Eye Res. 2022;92:101113.
Carnevali A, Capuano V, Sacconi R, Querques L, Marchese A, Rabiolo A, et al. OCT angiography of treatment-naïve quiescent choroidal neovascularization in pachychoroid neovasculopathy. Ophthalmol Retin. 2017;1:328–32.
doi: 10.1016/j.oret.2017.01.003
Sakurada Y, Fragiotta S, Leong BCS, Parikh R, Hussnain SA, Freund KB. Relationship between choroidal vascular hyperpermeability, choriocapillaris flow density, and choroidal thickness in eyes with pachychoroid pigment epitheliopathy. Retina. 2020;40:657.
doi: 10.1097/IAE.0000000000002635
pubmed: 31415450
Moult EM, Alibhai AY, Rebhun C, Lee B, Ploner S, Schottenhamml J, et al. Spatial distribution of choriocapillaris impairment in eyes with choroidal neovascularization secondary to age-related macular degeneration: a quantitative OCT angiography study. Retina. 2020;40:428–45.
doi: 10.1097/IAE.0000000000002556
pubmed: 31415449
pmcid: 7015807
Matsumoto H, Hoshino J, Mukai R, Nakamura K, Kishi S, Akiyama H. Chronic choriocapillaris ischemia in dilated vortex vein region in pachychoroid neovasculopathy. Sci Rep. 2021;11:16274.
doi: 10.1038/s41598-021-95904-9
pubmed: 34381134
pmcid: 8357816
Sacconi R, Tomasso L, Corbelli E, Carnevali A, Querques L, Casati S, et al. Early response to the treatment of choroidal neovascularization complicating central serous chorioretinopathy: a OCT-angiography study. Eye. 2019;33:1809–17.
doi: 10.1038/s41433-019-0511-2
pubmed: 31267094
pmcid: 7002717
Kokame GT, Liu K, Kokame KA, Kaneko KN, Omizo JN. Clinical characteristics of polypoidal choroidal vasculopathy and anti-vascular endothelial growth factor treatment response in caucasians. Ophthalmologica. 2019;243:178–86.
doi: 10.1159/000503834
pubmed: 31707394
Romdhane K, Zola M, Matet A, Daruich A, Elalouf M, Behar-Cohen F, et al. Predictors of treatment response to intravitreal anti-vascular endothelial growth factor (anti-VEGF) therapy for choroidal neovascularisation secondary to chronic central serous chorioretinopathy. Br J Ophthalmol. 2020;104:910–6.
doi: 10.1136/bjophthalmol-2019-314625
pubmed: 31615761
Hara C, Wakabayashi T, Sayanagi K, Nishida K. Refractory age-related macular degeneration due to concurrent central serous chorioretinopathy in previously well-controlled eyes. Pharmaceuticals. 2023;16:89.
doi: 10.3390/ph16010089
pubmed: 36678586
pmcid: 9864072
Narita C, Wu Z, Rosenfeld PJ, Yang J, Lyu C, Caruso E, et al. Structural OCT signs suggestive of subclinical nonexudative macular neovascularization in eyes with Large Drusen. Ophthalmology. 2020;127:637–47.
doi: 10.1016/j.ophtha.2019.11.007
pubmed: 31899036
Shi Y, Motulsky EH, Goldhardt R, Zohar Y, Thulliez M, Feuer W, et al. Predictive value of the OCT double-layer sign for identifying subclinical neovascularization in age-related macular degeneration. Ophthalmol Retin. 2019;3:211–9.
doi: 10.1016/j.oret.2018.10.012
Forte R, Coscas F, Serra R, Cabral D, Colantuono D, Souied EH. Long-term follow-up of quiescent choroidal neovascularisation associated with age-related macular degeneration or pachychoroid disease. Br J Ophthalmol. 2020;104:1057–63.
doi: 10.1136/bjophthalmol-2019-315189
pubmed: 31662311
Cheung CMG, Lai TYY, Teo K, Ruamviboonsuk P, Chen SJ, Kim JE, et al. Polypoidal choroidal vasculopathy: consensus nomenclature and non-indocyanine green angiograph diagnostic criteria from the Asia-Pacific Ocular Imaging Society PCV workgroup. Ophthalmology. 2021;128:443–52.
doi: 10.1016/j.ophtha.2020.08.006
pubmed: 32795496