Pre-exposure Prophylaxis (PrEP) implementation among latino MSM: a qualitative scoping review of implementation determinants and change methods.
Adjunctive Interventions
Barriers
Consolidated Framework for Implementation Research
Determinants
Facilitators
Implementation Science
Implementation Strategies
Latino MSM
Pre-exposure Prophylaxis
Journal
Implementation science communications
ISSN: 2662-2211
Titre abrégé: Implement Sci Commun
Pays: England
ID NLM: 101764360
Informations de publication
Date de publication:
30 Sep 2024
30 Sep 2024
Historique:
received:
07
11
2023
accepted:
16
09
2024
medline:
1
10
2024
pubmed:
1
10
2024
entrez:
1
10
2024
Statut:
epublish
Résumé
The increasing rates of HIV among Latino men who have sex with men (MSM) necessitate innovative and rigorous studies to evaluate prevention and treatment strategies. Pre-exposure prophylaxis (PrEP) is a highly effective tool in preventing HIV acquisition and plays a crucial role in the Ending the HIV Epidemic in the U.S. initiative. However, there is a scarcity of PrEP research specifically focused on Latino MSM, and the factors influencing its implementation remain largely unknown. To address this gap, we conducted a comprehensive review exploring the determinants (barriers and facilitators) of PrEP implementation among Latino MSM, as well as the change methods (implementation strategies and adjunctive interventions) that have been evaluated to promote its adoption. Our review encompassed 43 peer-reviewed articles examining determinants and four articles assessing change methods. Determinants were coded using the updated Consolidated Framework for Implementation Research (CFIR 2.0) to understand the multilevel barriers and facilitators associated with implementation. The majority of research has focused on PrEP recipients (i.e., patients), primarily examining their awareness and willingness to use PrEP. Fewer studies have explored the factors influencing clinicians and service delivery systems. Additionally, the evaluation of change methods to enhance clinician adoption and adherence to PrEP and recipient adherence to PrEP has been limited. It is evident that there is a need for culturally adapted strategies tailored specifically for Latino MSM, as the current literature remains largely unexplored in this regard. By incorporating principles from implementation science, we can gain a clearer understanding of the knowledge, skills, and roles necessary for effective cultural adaptations. Future research should emphasize factors influencing implementation from a clinician standpoint and focus on innovative change methods to increase PrEP awareness, reach, adoption, and sustained adherence among Latino MSM.
Identifiants
pubmed: 39350221
doi: 10.1186/s43058-024-00645-1
pii: 10.1186/s43058-024-00645-1
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
107Subventions
Organisme : NIH HHS
ID : P30 AI117943
Pays : United States
Organisme : NIMH NIH HHS
ID : T32MH130325
Pays : United States
Organisme : U.S. National Library of Medicine
ID : T15LM007124
Informations de copyright
© 2024. The Author(s).
Références
CDC. HIV and Hispanics/Latinos. 2020. Retrieved from https://www.cdc.gov/hiv/pdf/group/racialethnic/hispaniclatinos/cdc-hiv-latinos.pdf
CDC. HIV and Gay and Bisexual Men. 2023. Retrieved from https://www.cdc.gov/hiv/group/msm/index.html
Zapata JP, de St Aubin E, Rodriguez-Diaz CE, Malave-Rivera S. Using a structural-ecological model to facilitate adoption of preexposure prophylaxis among Latinx sexual minority men: a systematic literature review. J Latinx Psychol. 2022;10(3):169.
doi: 10.1037/lat0000204
Zapata JP, Avila AA, Hurtado M, Aubin ES, Rodriguez-Diaz CE, Robles G. Stakeholders’ perspectives about cultural strategies to support PrEP for latino sexual minority men. AIDS Educ Prev. 2023;35(3):185–200.
doi: 10.1521/aeap.2023.35.3.185
pubmed: 37410369
Eisinger RW, Fauci AS. Ending the global HIV Epidemic begins at the Individual National Level: an update from the United States. China CDC Wkly. 2020;2(39):764.
pmcid: 8393014
doi: 10.46234/ccdcw2020.163
pubmed: 34594757
Pitasi MA, Beer L, Cha S, Lyons SJ, Hernandez AL, Prejean J, Valleroy LA, Crim SM, Trujillo L, Hardman D, Painter EM. Vital signs: HIV infection, diagnosis, treatment, and prevention among gay, bisexual, and other men who have sex with men—United States, 2010–2019. Morb Mortal Wkly Rep. 2021;70(48):1669.
doi: 10.15585/mmwr.mm7048e1
Holt M, Lee E, Lea T, Bavinton B, Broady T, Mao L, et al. HIV Preexposure Prophylaxis cascades to assess implementation in Australia: results from repeated, national behavioral surveillance of Gay and Bisexual men, 2014–2018. J Acquir Immune Defic Syndr. 2020;83(3):e16–22.
doi: 10.1097/QAI.0000000000002243
pubmed: 31913993
Sullivan PS, Siegler AJ. What will it take to meet UNAIDS targets for preexposure prophylaxis users? Curr Opin Infect Dis. 2022;35(1):1–8.
doi: 10.1097/QCO.0000000000000809
pubmed: 34879049
Bauer MS, Kirchner J. Implementation science: what is it and why should I care? Psychiatry Res. 2020;283:112376.
doi: 10.1016/j.psychres.2019.04.025
pubmed: 31036287
Damschroder LJ, Aron DC, Keith RE, Kirsh SR, Alexander JA, Lowery JC. Fostering implementation of health services research findings into practice: a consolidated framework for advancing implementation science. Implement Sci. 2009;4(1):1–15.
doi: 10.1186/1748-5908-4-50
Damschroder LJ, Reardon CM, Opra Widerquist MA, Lowery J. Conceptualizing outcomes for use with the Consolidated Framework for Implementation Research (CFIR): the CFIR outcomes Addendum. Implement Sci. 2022;17(1):1–0.
doi: 10.1186/s13012-021-01181-5
Li DH, Benbow N, Keiser B, Mongrella M, Ortiz K, Villamar J, Gallo C, Deskins JS, Hall CD, Miller C, Mustanski B. Determinants of implementation for HIV pre-exposure prophylaxis based on an updated consolidated framework for implementation research: a systematic review. JAIDS J Acquir Immune Defic Syndr. 2022;90(S1):S235–46.
doi: 10.1097/QAI.0000000000002984
pubmed: 35703776
Queiroz A, Mongrella M, Keiser B, Li DH, Benbow N, Mustanski B. Profile of the portfolio of NIH-Funded HIV implementation Research projects to inform ending the HIV Epidemic Strategies. JAIDS J Acquir Immune Defic Syndr. 2022;90(S1):S23–31.
doi: 10.1097/QAI.0000000000002962
pubmed: 35703752
Lengnick-Hall R, Gerke DR, Proctor EK, Bunger AC, Phillips RJ, Martin JK, Swanson JC. Six practical recommendations for improved implementation outcomes reporting. Implement Sci. 2022;17(1):1–8.
doi: 10.1186/s13012-021-01183-3
Powell BJ, Waltz TJ, Chinman MJ, Damschroder LJ, Smith JL, Matthieu MM, et al. A refined compilation of implementation strategies: results from the Expert recommendations for Implementing Change (ERIC) project. Implement Sci. 2015;10(1):1–14.
doi: 10.1186/s13012-015-0209-1
Smith JD, Li DH, Merle JL, Keiser B, Mustanski B, Benbow ND. Adjunctive interventions: change methods directed at recipients that support uptake and use of health innovations. Implement Sci. 2024;19(1):10.
pmcid: 10854146
doi: 10.1186/s13012-024-01345-z
pubmed: 38331832
Merle JL, Li D, Keiser B, Zamantakis A, Queiroz A, Gallo CG, et al. Protocol: Categorising implementation determinants and strategies within the US HIV implementation literature: a systematic review protocol. BMJ Open. 2023;13(3):e070216.
pmcid: 10030793
doi: 10.1136/bmjopen-2022-070216
pubmed: 36927593
Harkness A, Lozano A, Bainter S, Mayo D, Hernandez Altamirano D, Rogers BG, et al. Engaging latino sexual minority men in PrEP and behavioral health care: multilevel barriers, facilitators, and potential implementation strategies. J Behav Med. 2023;46(4):655–67.
doi: 10.1007/s10865-022-00371-w
pubmed: 36472703
zamantakis A, Li DH, Benbow N, Smith JD, Mustanski B. Determinants of pre-exposure Prophylaxis (PrEP) implementation in Transgender populations: a qualitative scoping review. AIDS Behav. 2023;27(5):1600–18.
doi: 10.1007/s10461-022-03943-8
pubmed: 36520334
Mustanski B, Queiroz A, Merle J, Zamantakis A, Pablo Zapata J, Li H, Benbow D, Pyra N, Smith MD. A Systematic Review of Implementation Research on Determinants and Strategies of Effective HIV Interventions for Men Who Have Sex with Men in the United States. Ann Rev Psychol. 2023;75:55–85.
doi: 10.1146/annurev-psych-032620-035725
Tricco AC, Lillie E, Zarin W, O’Brien KK, Colquhoun H, Levac D, Moher D, Peters MD, Horsley T, Weeks L, Hempel S. PRISMA extension for scoping reviews (PRISMA-ScR): checklist and explanation. Ann Intern Med. 2018;169(7):467–73.
doi: 10.7326/M18-0850
pubmed: 30178033
Kuckartz U. Realizing mixed-methods approaches with MAXQDA. Marburg: Philipps-Universität; 2010.
De Leo A, Bayes S, Bloxsome D, Butt J. Exploring the usability of the COM-B model and theoretical domains Framework (TDF) to define the helpers of and hindrances to evidence-based practice in midwifery. Implement Sci Commun. 2021;2:1–8.
Proctor E, Silmere H, Raghavan R, Hovmand P, Aarons G, Bunger A, et al. Outcomes for implementation research: conceptual distinctions, measurement challenges, and research agenda. Adm Policy Mental Health Mental Health Serv Res. 2011;38:65–76.
doi: 10.1007/s10488-010-0319-7
Doll M, Fortenberry JD, Roseland D, McAuliff K, Wilson CM, Boyer CB. Linking HIV-negative youth to prevention services in 12 US cities: barriers and facilitators to implementing the HIV prevention continuum. J Adolesc Health. 2018;62(4):424–33.
doi: 10.1016/j.jadohealth.2017.09.009
pubmed: 29224988
García M, Harris AL. PrEP awareness and decision-making for Latino MSM in San Antonio, Texas. PLoS ONE. 2017;12(9):e0184014.
pmcid: 5617149
doi: 10.1371/journal.pone.0184014
pubmed: 28953905
Lelutiu-Weinberger C, Golub SA. Enhancing PrEP access for Black and Latino men who have sex with men. J Acquir Immune Defic Syndr. 2016;73(5):547–55.
pmcid: 5110381
doi: 10.1097/QAI.0000000000001140
pubmed: 27454250
Rivera DB, Brady JP, Blashill AJ. Traditional machismo, Caballerismo, and the pre-exposure prophylaxis (PreP) cascade among a sample of latino sexual minority men. J Sex Res. 2021;58(1):21–8.
doi: 10.1080/00224499.2020.1743961
pubmed: 32243199
Arnold EA, Hazelton P, Lane T, Christopoulos KA, Galindo GR, Steward WT, et al. A qualitative study of provider thoughts on implementing pre-exposure prophylaxis (PrEP) in clinical settings to prevent HIV infection. PLoS ONE. 2012;7(7):e40603.
pmcid: 3394704
doi: 10.1371/journal.pone.0040603
pubmed: 22792384
Miller RL, Boyer CB, Chiaramonte D, Lindeman P, Chutuape K, Cooper-Walker B, et al. Evaluating testing strategies for identifying youths with HIV infection and linking youths to Biomedical and other Prevention services. JAMA Pediatr. 2017;171(6):532–7.
pmcid: 5540008
doi: 10.1001/jamapediatrics.2017.0105
pubmed: 28418524
Liu AY, Vittinghoff E, von Felten P, Rivet Amico K, Anderson PL, Lester R, et al. Randomized controlled trial of a mobile health intervention to promote retention and adherence to preexposure prophylaxis among young people at risk for human immunodeficiency virus: the EPIC study. Clin Infect Dis. 2019;68(12):2010–7.
doi: 10.1093/cid/ciy810
pubmed: 30239620
Brooks RA, Nieto O, Santillan M Jr, Landrian A, Fehrenbacher AE, Cabral A. Beyond HIV prevention: additional individual and community-level benefits of PrEP among latino gay and bisexual men. PLoS ONE. 2022;17(6):e0269688.
pmcid: 9191695
doi: 10.1371/journal.pone.0269688
pubmed: 35696399
Shrader C-H, Arroyo-Flores J, Skvoretz J, Fallon S, Gonzalez V, Safren S, et al. PrEP use and PrEP use disclosure are associated with condom use during sex: a multilevel analysis of latino MSM egocentric sexual networks. AIDS Behav. 2021;25:1636–45.
pmcid: 8667162
doi: 10.1007/s10461-020-03080-0
pubmed: 33387134
Doblecki-Lewis S, Liu A, Feaster D, Cohen SE, Cardenas G, Bacon O, et al. Healthcare access and PrEP continuation in San Francisco and Miami following the US PrEP demo project. J Acquir Immune Defic Syndr. 2017;74(5):531–8.
pmcid: 5340616
doi: 10.1097/QAI.0000000000001236
pubmed: 27861236
Pérez-Figueroa RE, Kapadia F, Barton SC, Eddy JA, Halkitis PN. Acceptability of PrEP uptake among racially/ethnically diverse young men who have sex with men: the P18 study. AIDS Educ Prev. 2015;27(2):112–25.
pmcid: 4550097
doi: 10.1521/aeap.2015.27.2.112
pubmed: 25915697
Weinstein ER, Glynn TR, Simmons EM, Safren SA, Harkness A. Structural life instability and factors related to latino sexual minority men’s intention to engage with biomedical HIV-prevention services. AIDS Behav. 2022;26(12):3914–24.
pmcid: 9166207
doi: 10.1007/s10461-022-03718-1
pubmed: 35661015
Harkness A, Lozano A, Bainter S, Mayo D, Hernandez Altamirano D, Rogers BG, Prado G, Safren SA. Engaging latino sexual minority men in PrEP and behavioral health care: multilevel barriers, facilitators, and potential implementation strategies. J Behav Med. 2023;46(4):655–67.
doi: 10.1007/s10865-022-00371-w
pubmed: 36472703
Hosek SG, Green KR, Siberry G, Lally M, Balthazar C, Serrano PA, et al. Integrating behavioral HIV interventions into biomedical prevention trials with youth: lessons from Chicago’s project PrEPare. J HIV/AIDS Social Serv. 2013;12(3–4):333–48.
doi: 10.1080/15381501.2013.773575
Liu AY, Vittinghoff E, von Felten P, Rivet Amico K, Anderson PL, Lester R, Andrew E, Estes I, Serrano P, Brothers J, Buchbinder S. Randomized controlled trial of a mobile health intervention to promote retention and adherence to preexposure prophylaxis among young people at risk for human immunodeficiency virus: the EPIC study. Clin Infect Dis. 2019;68(12):2010–7.
doi: 10.1093/cid/ciy810
pubmed: 30239620
Lopez MI, Cocohoba J, Cohen SE, Trainor N, Levy MM, Dong BJ. Implementation of pre-exposure prophylaxis at a community pharmacy through a collaborative practice agreement with San Francisco Department of Public Health. J Am Pharmacists Association. 2020;60(1):138–44.
doi: 10.1016/j.japh.2019.06.021
Martinez O, Fernandez MI, Yang C, Wu E, Valentin O, Johnson M. Feasibility and acceptability pilot test of connecting latinos en parejas: a couples-based HIV Prevention intervention for latino male couples. Am J Men’s Health. 2023;17(2):15579883231167106.
doi: 10.1177/15579883231167106
Bandura A. Human agency in social cognitive theory. Am Psychol. 1989;44(9):1175.
doi: 10.1037/0003-066X.44.9.1175
pubmed: 2782727
Grimley D, Prochaska JO, Velicer WF, Blais LM, DiClemente CC. The transtheoretical model of change. Changing the self: Philosophies, techniques, and experiences. 1994. p. 201–27.
Fisher JD, Amico KR, Fisher WA, Harman JJ. The information-motivation-behavioral skills model of antiretroviral adherence and its applications. Curr HIV/AIDS Rep. 2008;5(4):193–203.
doi: 10.1007/s11904-008-0028-y
pubmed: 18838059
Wu C-H, You H-C, Deng Y-S. Investigating Persuasion in Sustainable Design to Change Behaviour and Attitude. New World Situation: New Directions in Concurrent Engineering: Proceedings of the 17th ISPE International Conference on Concurrent Engineering. Springer; 2010.
Zapata JP, Hurtado M, Avila AA, John SA, Rodriguez-Diaz CE, de St Aubin E. Factors Influencing Engagement Across the Motivational PrEP Cascade Among Latino SMM: A Mixed-Methods Analysis from the Perspectives of Community Providers and Latino SMM. AIDS Behav. 2024;23:1–5.
Ya-lin AH, Zhu W, Smith DK, Harris N, Hoover KW. HIV preexposure prophylaxis, by race and ethnicity—United States, 2014–2016. Morb Mortal Wkly Rep. 2018;67(41):1147.
doi: 10.15585/mmwr.mm6741a3
Merle JL, Zapata JP, Quieroz A, Zamantakis A, Sanuade O, Mustanski B, Smith JD. Pre-exposure prophylaxis (PrEP) among people who use drugs: a qualitative scoping review of implementation determinants and change methods. Addict Sci Clin Pract. 2024;19(1):46.
pmcid: 11138081
doi: 10.1186/s13722-024-00478-2
pubmed: 38816889
Koenig LJ, Lyles CM, Higa D, Mullins MM, Sipe TA. Research synthesis, HIV prevention response, and public health: CDC’s HIV/AIDS prevention research synthesis project. Public Health Rep. 2022;137(1):32–47.
doi: 10.1177/0033354920988871
pubmed: 33635724
Brewer R, Daunis C, Ebaady S, Wilton L, Chrestman S, Mukherjee S, Moore M, Corrigan R, Schneider J. Implementation of a socio-structural demonstration project to improve HIV outcomes among young Black men in the Deep South. J Racial Ethnic Health Disparities. 2019;6:775–89.
doi: 10.1007/s40615-019-00576-x
Phillips G, McCuskey D, Ruprecht MM, Curry CW, Felt D. Structural interventions for HIV prevention and care among US men who have sex with men: a systematic review of evidence, gaps, and future priorities. AIDS Behav. 2021;1:1–3.
Curran GM, Landes SJ, McBain SA, Pyne JM, Smith JD, Fernandez ME, Chambers DA, Mittman BS. Reflections on 10 years of effectiveness-implementation hybrid studies. Front Health Serv. 2022;2:1053496.
pmcid: 10012680
doi: 10.3389/frhs.2022.1053496
pubmed: 36925811
Smith JD, Li DH, Hirschhorn LR, Gallo C, McNulty M, Phillips G, Birkett M, Rafferty M, Rao A, Villamar JA, Baral S. Landscape of HIV implementation research funded by the National Institutes of Health: a mapping review of project abstracts. AIDS Behav. 2020;24:1903–11.
doi: 10.1007/s10461-019-02764-6
pubmed: 31845078