Galectin-1 is associated with hematopoietic cell engraftment in murine MHC-mismatched allotransplantation.
Animals
Hematopoietic Stem Cell Transplantation
Mice
Galectin 1
/ immunology
T-Lymphocytes, Regulatory
/ immunology
Mice, Inbred C57BL
Graft Rejection
/ immunology
Transplantation, Homologous
Major Histocompatibility Complex
/ immunology
Graft Survival
/ immunology
Mice, Inbred BALB C
Immune Tolerance
Tregs
chimerism
galectin-1
haplo-HCT
tolerance
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2024
2024
Historique:
received:
02
04
2024
accepted:
26
08
2024
medline:
1
10
2024
pubmed:
1
10
2024
entrez:
1
10
2024
Statut:
epublish
Résumé
Haploidentical hematopoietic cell transplantation (haplo-HCT) is associated with an increased risk of allograft rejection. Here, we employed a major histocompatibility complex (MHC)-mismatched allogeneic HCT (allo-HCT) murine model to better understand the role of Gal-1 in immune tolerance. Transplanted mice were classified into either rejected or engrafted based on donor chimerism levels. We noted significantly higher frequencies of CD4
Identifiants
pubmed: 39351218
doi: 10.3389/fimmu.2024.1411392
pmc: PMC11439684
doi:
Substances chimiques
Galectin 1
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1411392Informations de copyright
Copyright © 2024 Shaikh, Gangaplara, Kone, Almengo, Kabore, Ali, Xu, Saxena, Lopez-Ocasio, McCoy and Fitzhugh.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.