A meta-analysis and polygenic score study identifies novel genetic markers for waist-hip ratio in African populations.
Journal
Obesity (Silver Spring, Md.)
ISSN: 1930-739X
Titre abrégé: Obesity (Silver Spring)
Pays: United States
ID NLM: 101264860
Informations de publication
Date de publication:
01 Oct 2024
01 Oct 2024
Historique:
revised:
18
06
2024
received:
09
04
2024
accepted:
05
07
2024
medline:
1
10
2024
pubmed:
1
10
2024
entrez:
1
10
2024
Statut:
aheadofprint
Résumé
Understanding the genetic underpinnings of anthropometric traits in diverse populations is crucial for gaining insights into their biological mechanisms and potential implications for health. We conducted a genome-wide association study, meta-analysis, and gene set analysis of waist-hip ratio (WHR), WHR adjusted for BMI (WHRadjBMI), waist circumference, BMI, and height using the African Collaborative Center for Microbiome and Genomics Research (ACCME) cohort (n = ~11,000) for discovery and polygenic score target analyses and the Africa America Diabetes Mellitus (AADM) study (n = ~5200) for replication and polygenic score validation. We generated and compared polygenic scores from European, African, Afro-Caribbean, and multiethnic ancestry populations. The top loci associated with each trait in the meta-analysis were in CD36 (rs3211826 [p = 5.90 × 10 The discovery of a novel locus for WHR and genetic signals for each trait and the assessment of polygenic score performance underscore the importance of conducting well-powered studies in diverse populations.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : National Institutes of Health (NIH)
ID : U01HG011717
Organisme : National Institutes of Health (NIH)
ID : R03HL172139
Organisme : National Institutes of Health (NIH)
ID : U54HG006947
Organisme : National Institutes of Health (NIH)
ID : ZIAHG200362
Informations de copyright
© 2024 The Author(s). Obesity published by Wiley Periodicals LLC on behalf of The Obesity Society.
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