Polypeptide-Based Copper Ionophore for In Situ Glutathione-Triggered Chemodynamic and Chemotherapy.

Copper-based nanomedicine GSH depletion Polymeric ionophore Polypeptides Stimulus responsive

Journal

Molecular pharmaceutics
ISSN: 1543-8392
Titre abrégé: Mol Pharm
Pays: United States
ID NLM: 101197791

Informations de publication

Date de publication:
01 Oct 2024
Historique:
medline: 1 10 2024
pubmed: 1 10 2024
entrez: 1 10 2024
Statut: aheadofprint

Résumé

Intracellular copper ion homeostasis has become an attractive target for cancer therapy. Herein, we report a 2,2'-dipicolylamine (DPA) functionalized polyglutamate derivative (PDHB) which is capable of rapidly forming PDHB-copper complex (PDHB@Cu) due to the strong coordination ability of pendant DPA with Cu

Identifiants

DOI: 10.1021/acs.molpharmaceut.4c00883 PMID: 39351992
pubmed: 39351992
doi: 10.1021/acs.molpharmaceut.4c00883
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Auteurs

Ruoxue Wang (R)

Hebei Key Laboratory of Functional Polymers, Institute of Polymer Science and Engineering, School of Chemical Engineering, Hebei University of Technology, Tianjin 300130, P. R. China.

Liuxuan Li (L)

Hebei Key Laboratory of Functional Polymers, Institute of Polymer Science and Engineering, School of Chemical Engineering, Hebei University of Technology, Tianjin 300130, P. R. China.

Yu Guo (Y)

Hebei Key Laboratory of Functional Polymers, Institute of Polymer Science and Engineering, School of Chemical Engineering, Hebei University of Technology, Tianjin 300130, P. R. China.

Jianxin Rong (J)

Hebei Key Laboratory of Functional Polymers, Institute of Polymer Science and Engineering, School of Chemical Engineering, Hebei University of Technology, Tianjin 300130, P. R. China.

Furou Lv (F)

Hebei Key Laboratory of Functional Polymers, Institute of Polymer Science and Engineering, School of Chemical Engineering, Hebei University of Technology, Tianjin 300130, P. R. China.

Xiongwei Qu (X)

Hebei Key Laboratory of Functional Polymers, Institute of Polymer Science and Engineering, School of Chemical Engineering, Hebei University of Technology, Tianjin 300130, P. R. China.

Xiuli Hu (X)

Hebei Key Laboratory of Functional Polymers, Institute of Polymer Science and Engineering, School of Chemical Engineering, Hebei University of Technology, Tianjin 300130, P. R. China.
ORCID: 0000-0003-2641-0588

Classifications MeSH