Design of a multicenter randomized controlled trial of a post-discharge suicide prevention intervention for high-risk psychiatric inpatients: The Veterans Coordinated Community Care Study.
behavior
clinical trials
suicide
Journal
International journal of methods in psychiatric research
ISSN: 1557-0657
Titre abrégé: Int J Methods Psychiatr Res
Pays: United States
ID NLM: 9111433
Informations de publication
Date de publication:
Dec 2024
Dec 2024
Historique:
revised:
08
08
2024
received:
26
03
2024
accepted:
14
09
2024
medline:
1
10
2024
pubmed:
1
10
2024
entrez:
1
10
2024
Statut:
ppublish
Résumé
The period after psychiatric hospital discharge is one of elevated risk for suicide-related behaviors (SRBs). Post-discharge clinical outreach, although potentially effective in preventing SRBs, would be more cost-effective if targeted at high-risk patients. To this end, a machine learning model was developed to predict post-discharge suicides among Veterans Health Administration (VHA) psychiatric inpatients and target a high-risk preventive intervention. The Veterans Coordinated Community Care (3C) Study is a multicenter randomized controlled trial using this model to identify high-risk VHA psychiatric inpatients (n = 850) randomized with equal allocation to either the Coping Long Term with Active Suicide Program (CLASP) post-discharge clinical outreach intervention or treatment-as-usual (TAU). The primary outcome is SRBs over a 6-month follow-up. We will estimate average treatment effects adjusted for loss to follow-up and investigate the possibility of heterogeneity of treatment effects. Recruitment is underway and will end September 2024. Six-month follow-up will end and analysis will begin in Summer 2025. Results will provide information about the effectiveness of CLASP versus TAU in reducing post-discharge SRBs and provide guidance to VHA clinicians and policymakers about the implications of targeted use of CLASP among high-risk psychiatric inpatients in the months after hospital discharge. ClinicalTrials.Gov identifier: NCT05272176 (https://www. gov/ct2/show/NCT05272176).
Sections du résumé
BACKGROUND
BACKGROUND
The period after psychiatric hospital discharge is one of elevated risk for suicide-related behaviors (SRBs). Post-discharge clinical outreach, although potentially effective in preventing SRBs, would be more cost-effective if targeted at high-risk patients. To this end, a machine learning model was developed to predict post-discharge suicides among Veterans Health Administration (VHA) psychiatric inpatients and target a high-risk preventive intervention.
METHODS
METHODS
The Veterans Coordinated Community Care (3C) Study is a multicenter randomized controlled trial using this model to identify high-risk VHA psychiatric inpatients (n = 850) randomized with equal allocation to either the Coping Long Term with Active Suicide Program (CLASP) post-discharge clinical outreach intervention or treatment-as-usual (TAU). The primary outcome is SRBs over a 6-month follow-up. We will estimate average treatment effects adjusted for loss to follow-up and investigate the possibility of heterogeneity of treatment effects.
RESULTS
RESULTS
Recruitment is underway and will end September 2024. Six-month follow-up will end and analysis will begin in Summer 2025.
CONCLUSION
CONCLUSIONS
Results will provide information about the effectiveness of CLASP versus TAU in reducing post-discharge SRBs and provide guidance to VHA clinicians and policymakers about the implications of targeted use of CLASP among high-risk psychiatric inpatients in the months after hospital discharge.
CLINICAL TRIALS REGISTRATION
BACKGROUND
ClinicalTrials.Gov identifier: NCT05272176 (https://www.
CLINICALTRIALS
RESULTS
gov/ct2/show/NCT05272176).
Banques de données
ClinicalTrials.gov
['NCT05272176']
Types de publication
Journal Article
Randomized Controlled Trial
Multicenter Study
Clinical Trial Protocol
Langues
eng
Sous-ensembles de citation
IM
Pagination
e70003Subventions
Organisme : Department of Veterans Affairs Quality Enhancement Research Initiative
ID : EBP 22-104
Organisme : Department of Veterans Affairs Quality Enhancement Research Initiative
ID : PII 18-195
Organisme : Department of Veterans Affairs Quality Enhancement Research Initiative
ID : QUE 20-026
Organisme : Warren Alpert Foundation
Organisme : National Center for PTSD, U.S. Department of Veterans Affairs
ID : 36C24122P0883
Organisme : VA Boston Healthcare System
ID : 36C24122P0883
Organisme : NCATS NIH HHS
ID : UL1 TR003107
Pays : United States
Informations de copyright
© 2024 The Author(s). International Journal of Methods in Psychiatric Research published by John Wiley & Sons Ltd.
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