Saxitoxin potentiates human neuronal cell death induced by Zika virus while sparing neural progenitors and astrocytes.
Congenital Zika Syndrome (SCZ)
Induced pluripotent stem cells (IPSCS)
Neurons
Saxitoxin (STX)
Zika Virus (Zikv)
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
01 10 2024
01 10 2024
Historique:
received:
21
06
2024
accepted:
23
09
2024
medline:
3
10
2024
pubmed:
3
10
2024
entrez:
1
10
2024
Statut:
epublish
Résumé
The Zika virus (ZIKV) epidemic declared in Brazil between 2015 and 2016 was associated with an increased prevalence of severe congenital malformations, including microcephaly. The distribution of microcephaly cases was not uniform across the country, with a disproportionately higher incidence in the Northeast region (NE). Our previous work demonstrated that saxitoxin (STX), a toxin present in the drinking water reservoirs of the NE, exacerbated the damaging effects of ZIKV on the developing brain. We hypothesized that the impact of STX might vary among different neural cell types. While ZIKV infection caused severe damages on astrocytes and neural stem cells (NSCs), the addition of STX did not exacerbate these effects. We observed that neurons subjected to STX exposure were more prone to apoptosis and displayed higher ZIKV infection rate. These findings suggest that STX exacerbates the harmful effects of ZIKV on neurons, thereby providing a plausible explanation for the heightened severity of ZIKV-induced congenital malformations observed in Brazil's NE. This study highlights the importance of understanding the interactive effects of environmental toxins and infectious pathogens on neural development, with potential implications for public health policies.
Identifiants
pubmed: 39354036
doi: 10.1038/s41598-024-73873-z
pii: 10.1038/s41598-024-73873-z
doi:
Substances chimiques
Saxitoxin
35523-89-8
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
22809Subventions
Organisme : Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
ID : 88887.116625/2016-01 and 440909/2016-3
Organisme : Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
ID : 88887.116625/2016-01 and 440909/2016-3
Organisme : Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
ID : 88887.116625/2016-01 and 440909/2016-3
Organisme : Conselho Nacional de Desenvolvimento Científico e Tecnológico
ID : 440909/2016-3 and 441096/2016-6
Organisme : Conselho Nacional de Desenvolvimento Científico e Tecnológico
ID : 440909/2016-3 and 441096/2016-6
Organisme : Conselho Nacional de Desenvolvimento Científico e Tecnológico
ID : 440909/2016-3 and 441096/2016-6
Organisme : Conselho Nacional de Desenvolvimento Científico e Tecnológico
ID : 440909/2016-3 and 441096/2016-6
Organisme : Conselho Nacional de Desenvolvimento Científico e Tecnológico
ID : 440909/2016-3 and 441096/2016-6
Organisme : Pronas - Ministério da Saúde
ID : 25000.018857/2019-25
Organisme : Pronas - Ministério da Saúde
ID : 25000.018857/2019-25
Organisme : Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro
ID : E-26/201.340/2016, E-26/210.453/2021 and E-26/200.994/2021
Organisme : Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro
ID : E-26/201.340/2016, E-26/210.453/2021 and E-26/200.994/2021
Informations de copyright
© 2024. The Author(s).
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