Phenotypic evidence of deltamethrin resistance and identification of selective sweeps in Anopheles mosquitoes on the Bijagós Archipelago, Guinea-Bissau.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
01 Oct 2024
01 Oct 2024
Historique:
received:
15
02
2024
accepted:
23
09
2024
medline:
2
10
2024
pubmed:
2
10
2024
entrez:
1
10
2024
Statut:
epublish
Résumé
Vector control in the Bijagós Archipelago of Guinea-Bissau currently relies on pyrethroid insecticide-treated nets. However, data on insecticide resistance in Guinea-Bissau is limited. This study identified deltamethrin resistance in the Anopheles gambiae sensu lato complex on Bubaque island using WHO tube tests in November 2022. Whole genome sequencing of An. gambiae sensu stricto mosquitoes identified six single nucleotide polymorphisms (SNPs) previously associated with, or putatively associated with, insecticide resistance: T791M, L995F, N1570Y, A1746S and P1874L in the vgsc gene, and L119V in the gste2 gene. Twenty additional non-synonymous SNPs were identified in insecticide-resistance associated genes. Four of these SNPs were present at frequencies over 5% in the population: T154S, I126F and G26S in the vgsc gene and A65S in ace1. Genome wide selection scans using Garud's H
Identifiants
pubmed: 39354094
doi: 10.1038/s41598-024-73996-3
pii: 10.1038/s41598-024-73996-3
doi:
Substances chimiques
Pyrethrins
0
decamethrin
2JTS8R821G
Nitriles
0
Insecticides
0
Insect Proteins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
22840Subventions
Organisme : Medical Research Council
ID : MR/N013638/1
Pays : United Kingdom
Organisme : Joint Global Health Trials Scheme
ID : MRC, Wellcome Trust, UKRI, NIHR, Grant no. MR/S005013/1
Organisme : Joint Global Health Trials Scheme
ID : MRC, Wellcome Trust, UKRI, NIHR, Grant no. MR/S005013/1
Organisme : Joint Global Health Trials Scheme
ID : MRC, Wellcome Trust, UKRI, NIHR, Grant no. MR/S005013/1
Organisme : Joint Global Health Trials Scheme
ID : MRC, Wellcome Trust, UKRI, NIHR, Grant no. MR/S005013/1
Organisme : UK Research and Innovation
ID : BBSRC BB/X018156/1; MRC IAA2129, MR/R026297/1, and MR/X005895/1; EPSRC EP/Y018842/1
Organisme : UK Research and Innovation
ID : BBSRC BB/X018156/1; MRC IAA2129, MR/R026297/1, and MR/X005895/1; EPSRC EP/Y018842/1
Organisme : UK Research and Innovation
ID : BBSRC BB/X018156/1; MRC IAA2129, MR/R026297/1, and MR/X005895/1; EPSRC EP/Y018842/1
Informations de copyright
© 2024. The Author(s).
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