Carbon quantum dots composite for enhanced selective detection of dopamine with organic electrochemical transistors.
Bioelectronics
Carbon quantum dots
Differential pulse voltammetry; Amperometry
Dopamine
Organic electrochemical transistor
Poly(3, 4-ethylenedioxythiophene)
Journal
Mikrochimica acta
ISSN: 1436-5073
Titre abrégé: Mikrochim Acta
Pays: Austria
ID NLM: 7808782
Informations de publication
Date de publication:
01 Oct 2024
01 Oct 2024
Historique:
received:
29
07
2024
accepted:
19
09
2024
medline:
2
10
2024
pubmed:
2
10
2024
entrez:
1
10
2024
Statut:
epublish
Résumé
A compact organic electrochemical transistors (OECT) sensor enriched with carbon quantum dots (CQDs) was developed to enhance the transconductance of an electropolymerized poly(3,4-ethylenedioxythiophene) (PEDOT) film, enabling the precise and selective detection of dopamine (DA). Accurate monitoring of DA levels is critical for diagnosing and managing related conditions. Incorporating CQDs, we have achieved a remarkable up to threefold increase in current at the DA detection peak in differential pulse voltammetry. This enhancement showcases superior selectivity even in the presence of high concentrations of interferents like uric acid and ascorbic acid. This material significantly boosts the sensitivity of OECTs for DA detection, delivering an amperometric response with a detection limit of 55 nM and a broader detection range (1 - 500 µM). Our results underscore the potential of low-dimensional carbonaceous materials in creating cost-effective, high-sensitivity devices for detecting DA and other biomolecules. This breakthrough sets the stage for the development of next-generation biosensors for point-of-care diagnostics.
Identifiants
pubmed: 39354107
doi: 10.1007/s00604-024-06722-5
pii: 10.1007/s00604-024-06722-5
doi:
Substances chimiques
Dopamine
VTD58H1Z2X
Carbon
7440-44-0
poly(3,4-ethylene dioxythiophene)
0
Bridged Bicyclo Compounds, Heterocyclic
0
Polymers
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
639Subventions
Organisme : H2020 Marie Skłodowska-Curie Actions
ID : 955643
Organisme : Agència de Gestió d'Ajuts Universitaris i de Recerca
ID : 2021 SGR 00387
Organisme : Ministerio de Ciencia e Innovación
ID : CEX2023-001300-M
Informations de copyright
© 2024. The Author(s).
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