Impact of non-traditional lipid profiles on 1-year vascular outcomes in ischemic stroke patients with prior statin therapy and LDL-C < 100 mg/dL.

Humans Male Female Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use Aged Ischemic Stroke / blood Cholesterol, LDL / blood Middle Aged Prospective Studies Risk Factors Aged, 80 and over Lipids / blood Registries Myocardial Infarction / blood Stroke / blood

Acute ischemic stroke LDL-cholesterol LDL/HDL ratio Lipid ratio Non-traditional lipid profiles Residual cardiovascular risk Vascular outcome

Journal

Scientific reports

ISSN: 2045-2322

Titre abrégé: Sci Rep

Pays: England

ID NLM: 101563288

Informations de publication

Date de publication:
01 Oct 2024

Historique:

received: 12 06 2024

accepted: 20 09 2024

medline: 2 10 2024

pubmed: 2 10 2024

entrez: 1 10 2024

Statut: epublish

Résumé

This study aimed to investigate the association between non-traditional lipid profiles and the risk of 1-year vascular events in patients who were already using statins before stroke and had admission LDL-C < 100 mg/dL. This study was an analysis of a prospective, multicenter, nationwide registry of consecutive patients with acute ischemic stroke patients who treated with statin before index stroke and LDL-C < 100 mg/dL on admission. Non-traditional lipid profiles including non-HDL, TC/HDL ratio, LDL/HDL ratio, and TG/HDL ratio were analyzed as a continuous or categorical variable. The primary vascular outcome within one year was a composite of recurrent stroke (either hemorrhagic or ischemic), myocardial infarction (MI) and all-cause mortality. Hazard ratios (95% Cis) for 1-year vascular outcomes were analyzed using the Cox PH model for each non-traditional lipid profiles groups. A total of 7028 patients (age 70.3 ± 10.8years, male 59.8%) were finally analyzed for the study. In unadjusted analysis, no significant associations were observed in the quartiles of LDL/HDL ratio and 1-year primary outcome. However, after adjustment of relevant variables, compared with Q1 of the LDL/HDL ratio, Q4 was significantly associated with increasing the risk of 1-year primary outcome (HR 1.48 [1.19-1.83]). For the LDL/HDL ratio, a linear relationship was observed (P for linearity < 0.001). Higher quartiles of the LDL/HDL ratio were significantly and linearly associated with increasing the risk of 1-year primary vascular outcomes. These findings suggest that even during statin therapy with LDL-C < 100 mg/dl on admission, there should be consideration for residual risk based on the LDL/HDL ratio, following stroke.

Identifiants

DOI: 10.1038/s41598-024-73851-5 PMID: 39354143

pubmed: 39354143

doi: 10.1038/s41598-024-73851-5

pii: 10.1038/s41598-024-73851-5

doi:

Substances chimiques

Hydroxymethylglutaryl-CoA Reductase Inhibitors 0

Cholesterol, LDL 0

Lipids 0

Types de publication

Journal Article Multicenter Study

Langues

eng

Sous-ensembles de citation

Pagination

22794

Subventions

Organisme : Chonnam National University Hospital Biomedical Research Institute

ID : BCRI24042

Organisme : Research of Korea Centers for Disease Control and Prevention

ID : 2023-ER1006-00

Informations de copyright

Références

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