Physiological provocation compared to acetazolamide in the assessment of cerebral hemodynamics: a case report.
Brain
Cerebral perfusion
Cerebral perfusion imaging
Cerebrovascular reactivity
Hemodynamic failure
Limb shaking TIA
Positron emission tomography
Single photon emission computed tomography
Stroke
Journal
EJNMMI research
ISSN: 2191-219X
Titre abrégé: EJNMMI Res
Pays: Germany
ID NLM: 101560946
Informations de publication
Date de publication:
02 Oct 2024
02 Oct 2024
Historique:
received:
15
07
2024
accepted:
20
09
2024
medline:
2
10
2024
pubmed:
2
10
2024
entrez:
2
10
2024
Statut:
epublish
Résumé
Severe large vessel disease may lead to cerebral hemodynamic failure that critically impairs cerebral blood flow (CBF) regulation elevating the risk of ischemic events. Assessment of the condition is often based on changes in CBF during vasodilatation; however, pharmacologically induced vasodilation does not reflect the physiological condition during an ischemic event caused by hemodynamic failure. We compared a [ A single patient presenting with limb-shaking TIA underwent CT, Digital Subtraction Angiography, and two different modalities of cerebral perfusion scans: [ The observed discrepancy in compromised areas during physiological provocation compared to pharmacological induced vasodilation questions the use of an unphysiological stressor for assessment of cerebrovascular hemodynamics. A physiological provocation test may achieve more clinically relevant evaluation.
Sections du résumé
BACKGROUND
BACKGROUND
Severe large vessel disease may lead to cerebral hemodynamic failure that critically impairs cerebral blood flow (CBF) regulation elevating the risk of ischemic events. Assessment of the condition is often based on changes in CBF during vasodilatation; however, pharmacologically induced vasodilation does not reflect the physiological condition during an ischemic event caused by hemodynamic failure. We compared a [
CASE PRESENTATION
METHODS
A single patient presenting with limb-shaking TIA underwent CT, Digital Subtraction Angiography, and two different modalities of cerebral perfusion scans: [
CONCLUSIONS
CONCLUSIONS
The observed discrepancy in compromised areas during physiological provocation compared to pharmacological induced vasodilation questions the use of an unphysiological stressor for assessment of cerebrovascular hemodynamics. A physiological provocation test may achieve more clinically relevant evaluation.
Identifiants
pubmed: 39356412
doi: 10.1186/s13550-024-01154-x
pii: 10.1186/s13550-024-01154-x
doi:
Types de publication
Journal Article
Langues
eng
Pagination
89Informations de copyright
© 2024. The Author(s).
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