A new class of capsid-targeting inhibitors that specifically block HIV-1 nuclear import.
Antiretroviral Therapy
Capsid
Drug Discovery
HIV-1
Nuclear Import
Journal
EMBO molecular medicine
ISSN: 1757-4684
Titre abrégé: EMBO Mol Med
Pays: Germany
ID NLM: 101487380
Informations de publication
Date de publication:
02 Oct 2024
02 Oct 2024
Historique:
received:
29
02
2024
accepted:
02
09
2024
revised:
29
08
2024
medline:
3
10
2024
pubmed:
3
10
2024
entrez:
2
10
2024
Statut:
aheadofprint
Résumé
HIV-1 capsids cross nuclear pore complexes (NPCs) by engaging with the nuclear import machinery. To identify compounds that inhibit HIV-1 nuclear import, we screened drugs in silico on a three-dimensional model of a CA hexamer bound by Transportin-1 (TRN-1). Among hits, compound H27 inhibited HIV-1 with a low micromolar IC
Identifiants
pubmed: 39358603
doi: 10.1038/s44321-024-00143-w
pii: 10.1038/s44321-024-00143-w
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Sidaction
ID : AAP31-1-AEQ-12643
Organisme : Agence Nationale de Recherches sur le Sida et les Hépatites Virales (ANRS)
ID : ECTZ209411
Organisme : Montpellier Université d'Excellence (MUSE)
ID : iSite
Organisme : Wellcome Trust
ID : CC2029
Pays : United Kingdom
Organisme : Wellcome Trust
ID : CC1078
Pays : United Kingdom
Organisme : Wellcome Trust
ID : CC2029
Pays : United Kingdom
Organisme : Wellcome Trust
ID : CC2029
Pays : United Kingdom
Organisme : BIOLuM
ID : 2021
Informations de copyright
© 2024. The Author(s).
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