Audit of oral neoplasms in children and young adults in Nigeria.
Children
Neoplasm
Nigeria
Orofacial
Tumour
Young adults
Journal
BMC oral health
ISSN: 1472-6831
Titre abrégé: BMC Oral Health
Pays: England
ID NLM: 101088684
Informations de publication
Date de publication:
02 Oct 2024
02 Oct 2024
Historique:
received:
04
08
2024
accepted:
25
09
2024
medline:
3
10
2024
pubmed:
3
10
2024
entrez:
2
10
2024
Statut:
epublish
Résumé
Orofacial neoplasms in children and young adults may differ significantly from those observed in adults. Our aim was to describe the epidemiological characteristics of histologically diagnosed orofacial neoplasms among children and young adults in Nigeria. This was a multicenter cross-sectional study across geopolitical zones in Nigeria. Annual reports of clinical information and surgical biopsies submitted at the Oral Pathology Laboratory, clinic day registries, surgical day case registries and operative theatre registries were retrieved from January 2008 to March 2024. The relevant demographic data were obtained for each patient. The study subjects were categorized by age into children, adolescents and young adults. Tissue involvement was classified as soft tissue involvement, bony involvement or both soft tissue and bony involvement. The site and behaviour of the lesions were subdivided according to the ICD-10 codes. Statistical analysis was performed via the R programming language. A total of 1889 cases were observed during the period under review, with a mean age of 15 years. Cases were more common in females (52%) and in young adults (47%). Most cases were benign neoplasms (85%), and bony affectation (54%) was slightly predominant. Odontogenic tumours (38%) and fibro-osseous lesions (20%) were the most common category of lesions observed, whereas salivary gland tumours (2.2%) and neoplasms of epithelial origin (2.5%) were the least common. Neoplasms in children involved mostly soft tissues, whereas those in adolescents and young adults had a preference for bone (p < 0.001). In all age groups, benign lesions were mostly observed in the mouth and pharynx. For malignant lesions, in children, the bones of the skull and face were mostly involved, whereas in adolescents, the mandible was the predominant site (p < 0.001). In children, mesenchymal neoplasms were the most prevalent category of lesions, whereas in both adolescents and young adults, odontogenic tumours were more common. The proportion of malignant neoplasms in males was significantly greater than that in females (p < 0.001). This study revealed that although most biopsied orofacial lesions were more often benign, the proportion of malignant neoplasms in this population was greater than that previously reported.
Sections du résumé
BACKGROUND
BACKGROUND
Orofacial neoplasms in children and young adults may differ significantly from those observed in adults. Our aim was to describe the epidemiological characteristics of histologically diagnosed orofacial neoplasms among children and young adults in Nigeria.
METHODS
METHODS
This was a multicenter cross-sectional study across geopolitical zones in Nigeria. Annual reports of clinical information and surgical biopsies submitted at the Oral Pathology Laboratory, clinic day registries, surgical day case registries and operative theatre registries were retrieved from January 2008 to March 2024. The relevant demographic data were obtained for each patient. The study subjects were categorized by age into children, adolescents and young adults. Tissue involvement was classified as soft tissue involvement, bony involvement or both soft tissue and bony involvement. The site and behaviour of the lesions were subdivided according to the ICD-10 codes. Statistical analysis was performed via the R programming language.
RESULTS
RESULTS
A total of 1889 cases were observed during the period under review, with a mean age of 15 years. Cases were more common in females (52%) and in young adults (47%). Most cases were benign neoplasms (85%), and bony affectation (54%) was slightly predominant. Odontogenic tumours (38%) and fibro-osseous lesions (20%) were the most common category of lesions observed, whereas salivary gland tumours (2.2%) and neoplasms of epithelial origin (2.5%) were the least common. Neoplasms in children involved mostly soft tissues, whereas those in adolescents and young adults had a preference for bone (p < 0.001). In all age groups, benign lesions were mostly observed in the mouth and pharynx. For malignant lesions, in children, the bones of the skull and face were mostly involved, whereas in adolescents, the mandible was the predominant site (p < 0.001). In children, mesenchymal neoplasms were the most prevalent category of lesions, whereas in both adolescents and young adults, odontogenic tumours were more common. The proportion of malignant neoplasms in males was significantly greater than that in females (p < 0.001).
CONCLUSION
CONCLUSIONS
This study revealed that although most biopsied orofacial lesions were more often benign, the proportion of malignant neoplasms in this population was greater than that previously reported.
Identifiants
pubmed: 39358779
doi: 10.1186/s12903-024-04958-4
pii: 10.1186/s12903-024-04958-4
doi:
Types de publication
Journal Article
Multicenter Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
1169Informations de copyright
© 2024. The Author(s).
Références
Keyur BRS, Joshi S, AK JGD. Introduction to neoplasm: a review article. Int J Adv Res Pharmaceut Bio Sci. 2012;1(3):65–72.
Patel A. Benign vs malignant tumors. JAMA Oncol. 2020;6(9):1488.
doi: 10.1001/jamaoncol.2020.2592
pubmed: 32729930
da Silva Barros CC, da Silva LP, Gonzaga AKG, de Medeiros AMC, de Souza LB, da Silveira ÉJD. Neoplasms and nonneoplastic pathologies in the oral and maxillofacial regions in children and adolescents of a Brazilian population. Clin Oral Investig. 2019;23:1587–93.
doi: 10.1007/s00784-018-2581-0
pubmed: 30143900
Vale EB, Ramos-Perez FMM, Rodrigues GLC, Carvalho EJA, Castro JFL, Perez DEC. A review of oral biopsies in children and adolescents: a clinicopathological study of a case series. J Clin Exp Dent. 2013;5(3): e144.
doi: 10.4317/jced.51122
pubmed: 24455070
pmcid: 3892252
Mahmoudi P, Razavi SM, Tahani B. Orofacial pathological lesions in children and adolescents: A 25-year survey in Iran. J Dent. 2018;19(4):265.
Orikpete EV, Iyogun CA, Omitola OG. Clinicopathologic analysis of biopsied orofacial lesions seen in children in a tertiary health centre in port harcourt: an 11-year review. J Biosci Med (Irvine). 2020;8(3):1–8.
Saravani S, Kadeh H, Amirabadi F, Keramati N. Clinical and histopathological profiles of pediatric and adolescent oral and maxillofacial biopsies in a Persian population. Int J Pediatr. 2015;3(1.1):381–90.
Yu Z, Seo B, Hussaini HM, Meldrum AM, Rich AM. The relative frequency of paediatric oral and maxillofacial pathology in New Zealand: A 10-year review of a national specialist centre. Int J Paediatr Dent. 2020;30(2):209–15.
doi: 10.1111/ipd.12590
pubmed: 31692163
Ibikunle AA, Taiwo AO, Braimah RO, Umar MS. A review of oral and maxillofacial biopsies from a new academic health facility in remote Northwestern Nigeria. Int J Oral Health Scienc. 2018;8(2):86–91.
doi: 10.4103/ijohs.ijohs_25_18
Aregbesola SB, Ugboko VI, Akinwande JA, Arole GF, Fagade OO. Orofacial tumours in suburban Nigerian children and adolescents. Br J Oral Maxillofac Surg. 2005;43(3):226–31.
doi: 10.1016/j.bjoms.2004.11.006
pubmed: 15888358
Blankson PK, Amoah G, Thadani M, Newman-Nartey M, Amarquaye G, Hewlett S, et al. Prevalence of oral conditions and associated factors among schoolchildren in Accra, Ghana: a cross-sectional study. Int Dent J. 2022;72(1):93–9.
doi: 10.1016/j.identj.2021.02.004
pubmed: 33781557
Sohal KS, Moshy JR. Oral and maxillofacial tumors;: An audit in paediatric patients attended in MNH, Tanzania: A 6 year retrospective study. Profession Med Jo. 2017;24(03):433–40.
doi: 10.29309/TPMJ/2017.24.03.1548
Lawal AO, Adisa AO, Popoola BO. Odontogenic tumours in children and adilescents: a review od forty-eight cases. Ann Ib Postgrad Med. 2013;11(1):7–11.
pubmed: 25161416
pmcid: 4111056
Taiwo AO, Braimah RO, Ibikunle AA, Obileye MF, Jiya NM, Sahabi SM, et al. Oral and maxillofacial tumours in children and adolescents: Clinicopathologic audit of 75 cases in an academic medical centre, Sokoto, Northwest Nigeria. Afr J Paediatr Surg. 2017;14(3):37–42.
doi: 10.4103/ajps.AJPS_81_16
pubmed: 29557349
pmcid: 5881284
Anyanechi CE. Paediatric and adolescent intrabony oro-facial tumours and allied lesions in a Nigeria tertiary health facility: An 18-year retrospective analysis. J Oral Maxillofac Surg Med Pathol. 2015;27(3):412–7.
doi: 10.1016/j.ajoms.2014.10.008
Ladeji A, Aborisade A, Olajide M, Oyedele T, Adebiyi K, Kuye O, et al. Paediatric orofacial malignancies in an African population. J Paediatr Dent Resear and Practice. 2023;4(1–2):10–9.
UNAIDS report on the global AIDS epidemic 2013. Geneva: Joint United Nations Programme on HIV/AIDS; 2013. Geneva; 2014.
Steindel SJ. International classification of diseases, 10th edition, clinical modification and procedure coding system: Descriptive overview of the next generation HIPAA code sets. Journal of the American Medical Informatics Association. 2010;17:274–82.
doi: 10.1136/jamia.2009.001230
pubmed: 20442144
pmcid: 2995704
Akinyamoju AO, Adeyemi BF, Adisa AO, Okoli CN. Audit of oral histopathology service at a Nigerian tertiary institution over a 24-year period. Ethiop J Health Sci. 2017;27(4):383–92.
doi: 10.4314/ejhs.v27i4.9
pubmed: 29217940
pmcid: 5615027
Mileno P. The largest black nation outside frica and its racist politics. Ufahamu. 2018;41(1):xv–xxiii.
Omoregie FO, Akpata O. Paediatric orofacial tumours: new oral health concern in paediatric patients. Ghana Med J. 2014;48(1):14–9.
doi: 10.4314/gmj.v48i1.2
pubmed: 25320396
pmcid: 4196529
Patil SS, Kontham UR, Kontham RK, Chowdhery A. Retrospective evaluation of paediatric oral biopsies over a 10-year period in Western India. Eur Arch Paediatr Dent. 2017;18:171–8.
doi: 10.1007/s40368-017-0281-0
pubmed: 28365866
Abdulai AE, Nuamah IK, Gyasi R. Head and neck tumours in Ghanaian children. A 20 year review. Int J Oral Maxillofac Surg. 2012;41(11):1378–82.
doi: 10.1016/j.ijom.2012.06.004
pubmed: 22771221
Martins-Filho PRS, de Santana ST, Piva MR, da Silva HF, da Silva LCF, Mascarenhas-Oliveira AC, et al. A multicenter retrospective cohort study on pediatric oral lesions. J Dent Child. 2015;82(2):84–90.
Puangwan Lapthanasupkul D, Juengsomjit R, Sopee PD. Oral and maxillofacial lesions in a Thai pediatric population: a retrospective review from two dental schools. J Med Assoc Thai. 2015;98(3):291–7.
pubmed: 25920300
Iatrou I, Theologie-Lygidakis N, Tzerbos F, Schoinohoriti OK. Oro-facial tumours and tumour-like lesions in Greek children and adolescents: an 11-year retrospective study. Journal of Cranio-Maxillofacial Surgery. 2013;41(5):437–43.
doi: 10.1016/j.jcms.2012.11.010
pubmed: 23270683
Prosdócimo ML, Agostini M, Romañach MJ. A retrospective analysis of oral and maxillofacial pathology in a pediatric population from Rio de Janeiro-Brazil over a 75-year period. Med Oral Patol Oral Cir Bucal. 2018;23(5): e511.
pubmed: 30148463
pmcid: 6167092
Ha WN, Kelloway E, Dost F, Farah CS. A retrospective analysis of oral and maxillofacial pathology in an Australian paediatric population. Aust Dent J. 2014;59(2):221–5.
doi: 10.1111/adj.12174
pubmed: 24861398
Gültelkin SE, Türkseven MR. A review of paediatric oral biopsies in Turkey. Int Dent J. 2003;53(1):26–32.
doi: 10.1111/j.1875-595X.2003.tb00652.x
pubmed: 12653336
Okumu SB, Chindia ML, Gathece LW, Dimba EAO, Odhiambo W. Clinical features and types of paediatric orofacial malignant neoplasms at two hospitals in Nairobi. Kenya Journal of Cranio-Maxillofacial Surgery. 2012;40(1):e8-14.
doi: 10.1016/j.jcms.2011.01.020
pubmed: 21376609
Soyele OO, Aborisade A, Adesina OM, Olatunji A, Adedigba M, Ladej AM, et al. Concordance between clinical and histopathologic diagnosis and an audit of oral histopathology service at a Nigerian tertiary hospital. Pan Africa Med J. 2019;34(1).
Butt FM, Ogeng’o JA, Bahra J, Chindia ML, Dimba EAO, Wagaiyu E. 19-year audit of BenignJaw tumours and tumour-like lesions in a teaching hospital in Nairobi, Kenya. 2012.
Butt FMA, Guthua SW, Awange DA, Dimba EAO, MacIgo FG. The pattern and occurrence of ameloblastoma in adolescents treated at a university teaching hospital, in Kenya: A 13-year study. J Craniomaxillofac Surg. 2012;40(2):e39.
doi: 10.1016/j.jcms.2011.03.011
pubmed: 21458287
Jones AV, Franklin CD. An analysis of oral and maxillofacial pathology found in children over a 30-year period. Int J Paediatr Dent. 2006;16(1):19–30.
doi: 10.1111/j.1365-263X.2006.00683.x
pubmed: 16364089
Ajayi OF, Adeyemo WL, Ladeinde AL, Ogunlewe MO, Omitola OG, Effiom OA, et al. Malignant orofacial neoplasms in children and adolescents: a clinicopathologic review of cases in a Nigerian tertiary hospital. Int J Pediatr Otorhinolaryngol. 2007;71(6):959–63.
doi: 10.1016/j.ijporl.2007.03.008
pubmed: 17418424
Lefeuvre C, Roux M, Blanchard S, Le Guillou-Guillemette H, Boursier J, Lunel-Fabiani F, et al. Analysis of hepatic fibrosis markers in the serum of chronic hepatitis B patients according to basal core promoter/precore mutants. Sci Rep. 2022;12(1):10261.
doi: 10.1038/s41598-022-14285-9
pubmed: 35715541
pmcid: 9205978