HArmonyCa™ hybrid filler to restore connective tissue: An Italian real-life retrospective study.
HArmonyCa™
calcium hydroxylapatite
face rejuvenation
hyaluronic acid
hybrid filler
Journal
Journal of cosmetic dermatology
ISSN: 1473-2165
Titre abrégé: J Cosmet Dermatol
Pays: England
ID NLM: 101130964
Informations de publication
Date de publication:
03 Oct 2024
03 Oct 2024
Historique:
revised:
01
07
2024
received:
15
04
2024
accepted:
23
07
2024
medline:
3
10
2024
pubmed:
3
10
2024
entrez:
3
10
2024
Statut:
aheadofprint
Résumé
Facial aging and dermal conditions may negatively influence the quality of life, leading patients to seek aesthetic procedures to restore a more satisfying appearance. HArmonyCa™ is a recently developed hybrid filler that combines the actions of the most common dermal fillers, hyaluronic acid (HA) and calcium hydroxylapatite (CaHA). This study investigates the efficacy and safety of HArmonyCa™ in patients affected by chrono- and photoaging and several facial skin conditions. One hundred and twenty-nine patients, affected by chrono- and photoaging, and skin conditions such as oily and acne-prone skin, rosacea, or scarring, were treated with HArmonyCa™. Injections followed the retrograde linear fanning technique. A physicians' consensus identified five optimal entry points. The physician and patients assessed treatment outcomes using the Global Aesthetic Improvement Scale (GAIS) 9 months after treatment (including immediate lift effect, skin firmness, and elasticity), and 3D images were taken for documentation. Adverse events (AEs) were evaluated immediately after the procedure and after 9 months. According to the physician's assessments, all patients displayed an improvement in facial appearance, particularly during movement, with the patients' evaluation showing agreement. Only minor AEs were reporte, which resolved spontaneously. Moreover, HArmonyCa™ treatment proved compatible with different medications and aesthetic procedures. This study shows that one treatment with HArmonyCa™ yields highly satisfactory outcomes in patients affected by skin conditions. For the first time, we show that HArmonyCa™ is a dynamic filler that improves facial laxity during movement. The treatment proved to be safe and fully compatible with other cosmetic procedures and medications.
Sections du résumé
BACKGROUND
BACKGROUND
Facial aging and dermal conditions may negatively influence the quality of life, leading patients to seek aesthetic procedures to restore a more satisfying appearance. HArmonyCa™ is a recently developed hybrid filler that combines the actions of the most common dermal fillers, hyaluronic acid (HA) and calcium hydroxylapatite (CaHA).
AIMS
OBJECTIVE
This study investigates the efficacy and safety of HArmonyCa™ in patients affected by chrono- and photoaging and several facial skin conditions.
PATIENTS/METHODS
METHODS
One hundred and twenty-nine patients, affected by chrono- and photoaging, and skin conditions such as oily and acne-prone skin, rosacea, or scarring, were treated with HArmonyCa™. Injections followed the retrograde linear fanning technique. A physicians' consensus identified five optimal entry points. The physician and patients assessed treatment outcomes using the Global Aesthetic Improvement Scale (GAIS) 9 months after treatment (including immediate lift effect, skin firmness, and elasticity), and 3D images were taken for documentation. Adverse events (AEs) were evaluated immediately after the procedure and after 9 months.
RESULTS
RESULTS
According to the physician's assessments, all patients displayed an improvement in facial appearance, particularly during movement, with the patients' evaluation showing agreement. Only minor AEs were reporte, which resolved spontaneously. Moreover, HArmonyCa™ treatment proved compatible with different medications and aesthetic procedures.
CONCLUSIONS
CONCLUSIONS
This study shows that one treatment with HArmonyCa™ yields highly satisfactory outcomes in patients affected by skin conditions. For the first time, we show that HArmonyCa™ is a dynamic filler that improves facial laxity during movement. The treatment proved to be safe and fully compatible with other cosmetic procedures and medications.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2024 The Author(s). Journal of Cosmetic Dermatology published by Wiley Periodicals LLC.
Références
Liang Y, Su W, Wang F. Skin ageing: a progressive, multi‐factorial condition demanding an integrated Multilayer‐Targeted Remedy. Clin Cosmet Investig Dermatol. 2023;16:1215‐1229. doi:10.2147/CCID.S408765
Fisher GJ, Kang S, Varani J, et al. Mechanisms of photoaging and chronological skin aging. Arch Dermatol. 2002;138(11):1462‐1470. doi:10.1001/archderm.138.11.1462
Barone M, Salzillo R, De Bernardis R, Persichetti P. Randomized controlled study using autologous fat grafts, hybrid filler, and fractional CO2 laser resurfacing in the treatment of elastosis: analysis of outcomes and satisfaction. Eur J Plast Surg. 2024;47(1):3. doi:10.1007/s00238-023-02151-4
Urdiales‐Gálvez F, Braz A, Cavallini M. Facial rejuvenation with the new hybrid filler HArmonyCa™: clinical and aesthetic outcomes assessed by 2D and 3D photographs, ultrasound, and elastography. J Cosmet Dermatol. 2023;22(8):2186‐2197. doi:10.1111/jocd.15706
Bravo BSF, Almeida TSCD, Carvalho RDM, Machado CJ, Bravo LG, Elias MC. Dermal thickness increase and aesthetic improvement with hybrid product combining hyaluronic acid and calcium hydroxyapatite: a clinical and sonographic analysis. Plast Reconstr Surg—Glob Open. 2023;11(6):e5055. doi:10.1097/GOX.0000000000005055
Choy SP, Kim BJ, Paolino A, et al. Systematic review of deep learning image analyses for the diagnosis and monitoring of skin disease. NPJ Digit Med. 2023;6(1):180. doi:10.1038/s41746-023-00914-8
Sparavigna A, Grimolizzi F, Cigni C, Lualdi R, Bellia G. Efficacy and tolerability of Profhilo® Structura intended to restore lateral cheek fat compartment: an observational pilot study. Health Sci Rep. 2024;7(1):e1743. doi:10.1002/hsr2.1743
Al‐Ghanim K, Richards R, Cohen S. A practical guide to selecting facial fillers. J Cosmet Dermatol. 2023;22(12):3232‐3236. doi:10.1111/jocd.15867
Go BC, Frost AS, Friedman O. Using injectable fillers for chin and jawline rejuvenation. World J Otorhinolaryngol—Head Neck Surg. 2023;9(2):131‐137. doi:10.1002/wjo2.93
Barone M, Salzillo R, Persichetti P. Minimally invasive facial rejuvenation with the hybrid filler HArmonyCa™. Aesth Plast Surg. 2023;9. Online ahead of print. doi:10.1007/s00266-023-03649-9
Yag‐Howard C, DeNigris J. Novel filler technique: hyaluronic acid and calcium hydroxylappetite mixture resulting in favorable esthetic and longevity outcomes. Int J Womens Dermatol. 2021;7(5):817‐819. doi:10.1016/j.ijwd.2021.09.008
Guida S, Galadari H. A systematic review of Radiesse/calcium hydroxylapatite and carboxymethylcellulose: evidence and recommendations for treatment of the face. Int J Dermatol. 2024;63(2):150‐160. doi:10.1111/ijd.16888
Fakih‐Gomez N, Kadouch J. Combining calcium hydroxylapatite and hyaluronic acid fillers for aesthetic indications: efficacy of an innovative hybrid filler. Aesth Plast Surg. 2022;46(1):373‐381. doi:10.1007/s00266-021-02479-x
Proietti I, Dybala AE, Garori M, Potenza C. New protocol: EndoliftX laser and hyaluronic Ac+ calcium Hydroxiapaptite as an effective approach for facial rejuvenation‐ case series of 7 patients. Dermatol J Cosmet Laser Ther. 2023;2(3):39‐48. doi:10.33140/DJCLT.02.03.05
Proietti I, Skroza N, Tolino E, Dybala AE, Potenza C. Facial segmental lipoatrophy effectively treated with a deep priming filler incorporating calcium hydroxyapatite with results sustained for 12 months. J Cosmet Dermatol. 2024;23(3):1101‐1103. doi:10.1111/jocd.16083
Karsten AE, Smit JE. Modeling and verification of melanin concentration on human skin type. Photochem Photobiol. 2012;88(2):469‐474. doi:10.1111/j.1751-1097.2011.01044.x
Braz A, Eduardo CCDP. The facial shapes in planning the treatment with injectable fillers. Indian J Plast Surg. 2020;53(2):230‐243. doi:10.1055/s-0040-1715554
Narins RS, Brandt F, Leyden J, Lorenc ZP, Rubin M, Smith S. A randomized, double‐blind, multicenter comparison of the efficacy and tolerability of Restylane versus Zyplast for the correction of nasolabial folds. Dermatologic Surg. 2003;29(6):588‐595. doi:10.1046/j.1524-4725.2003.29150.x
Sparavigna A. Role of the extracellular matrix in skin aging and dedicated treatment—state of the art. Plast Aesthet Res. 2020;7:14. doi:10.20517/2347-9264.2019.73
Swift A, Liew S, Weinkle S, Garcia JK, Silberberg MB. The facial aging process from the "inside out". Aesthet Surg J. 2021;41(10):1107‐1119. doi:10.1093/asj/sjaa339
Chang JW, Koo WY, Kim EK, Lee SW, Lee JH. Facial rejuvenation using a mixture of calcium Hydroxylapatite filler and hyaluronic acid filler. J Craniofac Surg. 2020;31(1):e18‐e21. doi:10.1097/SCS.0000000000005809
Proietti I, Svara F, Battilotti C, Innocenzi C, Potenza C. Integrated management with topical and injectable 200 kDa hyaluronic acid for erythematous rosacea. J Cosmet Dermatol. 2024. Online ahead of print. doi:10.1111/JOCD.16342
Al‐Hage J, Galadari HI. The needle versus cannula debate in soft tissue augmentation. Dermatol Clin. 2024;42(1):69‐77. doi:10.1016/j.det.2023.06.010
Braz A, Colucci L, Macedo De Oliveira L, et al. A retrospective analysis of safety in participants treated with a hybrid hyaluronic acid and calcium hydroxyapatite filler. Plast Reconstr Surg—Glob Open. 2024;12(2):e5622. doi:10.1097/GOX.0000000000005622
Aryanian Z, Balighi K, Emadi SN, Razavi Z, Hatami P, Afshar ZM. COVID ‐19 vaccines and filler reactions: should it be considered as a concern? J Cosmet Dermatol. 2022;21(12):6564‐6567. doi:10.1111/jocd.15428
Munavalli GG, Guthridge R, Knutsen‐Larson S, Brodsky A, Matthew E, Landau M. COVID‐19/SARS‐CoV‐2 virus spike protein‐related delayed inflammatory reaction to hyaluronic acid dermal fillers: a challenging clinical conundrum in diagnosis and treatment. Arch Dermatol Res. 2022;314(1):1‐15. doi:10.1007/s00403-021-02190-6