Prevalence and concordance of penile, anal, and oral human papillomavirus infections among sexually active heterosexual men in Ibadan, Nigeria.
Anal
Ano-genital or oro-genital
Concordance
HPV
Men
Nigeria
Oral human papillomavirus
Penile
Prevalence
Journal
Cancer causes & control : CCC
ISSN: 1573-7225
Titre abrégé: Cancer Causes Control
Pays: Netherlands
ID NLM: 9100846
Informations de publication
Date de publication:
03 Oct 2024
03 Oct 2024
Historique:
received:
09
04
2024
accepted:
16
09
2024
medline:
3
10
2024
pubmed:
3
10
2024
entrez:
3
10
2024
Statut:
aheadofprint
Résumé
The data on epidemiology of Human papillomavirus (HPV) infections in men are scarce relative to women generally, particularly among men engaging in heterosexual relationships. This study investigated the prevalence and risk factors for penile, anal, and oral HPV in men in two communities in Ibadan, Nigeria. This was a cross-sectional survey involving a face-to-face interview, a clinical examination, and sample collection from participants. HPV genotyping was performed with Anyplex II 28 HPV assay. The prevalences and factors associated with HPV infections using multivariable models and concordance between sites. Of 316 men, the proportion of any HPV infection in the penile, anal, and oral sites was 40.5%, 9.7%, and 7.8%, respectively. The proportion of any high-risk HPV, low-risk HPV, and multiple HPV infections was highest in the penis followed by the anal and oral sites. Only 5/316 (1.6%) men had concordant HPV in all three sites, with the highest concordance in penile-anal sites relative to penile-oral and anal-oral sites. The odds of penile HPV were higher in men aged 25 years and above. Having penile HPV was associated with higher odds of detecting anal HPV and vice versa. Oral HPV was less likely in men not living with their sexual partners. Penile HPV is the most common infection followed by anal HPV and oral HPV infections among heterosexual Nigerian men. Concordant HPV infections was highest in penile-anal sites. Nigerian men, as in other settings, are a reservoir of HPV and it is important to conduct more robust studies to appreciate their role in HPV transmission, epidemiology, and prevention.
Sections du résumé
BACKGROUND
BACKGROUND
The data on epidemiology of Human papillomavirus (HPV) infections in men are scarce relative to women generally, particularly among men engaging in heterosexual relationships. This study investigated the prevalence and risk factors for penile, anal, and oral HPV in men in two communities in Ibadan, Nigeria.
METHODS
METHODS
This was a cross-sectional survey involving a face-to-face interview, a clinical examination, and sample collection from participants. HPV genotyping was performed with Anyplex II 28 HPV assay. The prevalences and factors associated with HPV infections using multivariable models and concordance between sites.
RESULTS
RESULTS
Of 316 men, the proportion of any HPV infection in the penile, anal, and oral sites was 40.5%, 9.7%, and 7.8%, respectively. The proportion of any high-risk HPV, low-risk HPV, and multiple HPV infections was highest in the penis followed by the anal and oral sites. Only 5/316 (1.6%) men had concordant HPV in all three sites, with the highest concordance in penile-anal sites relative to penile-oral and anal-oral sites. The odds of penile HPV were higher in men aged 25 years and above. Having penile HPV was associated with higher odds of detecting anal HPV and vice versa. Oral HPV was less likely in men not living with their sexual partners.
CONCLUSION
CONCLUSIONS
Penile HPV is the most common infection followed by anal HPV and oral HPV infections among heterosexual Nigerian men. Concordant HPV infections was highest in penile-anal sites. Nigerian men, as in other settings, are a reservoir of HPV and it is important to conduct more robust studies to appreciate their role in HPV transmission, epidemiology, and prevention.
Identifiants
pubmed: 39361165
doi: 10.1007/s10552-024-01920-1
pii: 10.1007/s10552-024-01920-1
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2024. The Author(s), under exclusive licence to Springer Nature Switzerland AG.
Références
de Martel C et al (2017) Worldwide burden of cancer attributable to HPV by site, country and HPV type. Int J Cancer 141(4):664–670
doi: 10.1002/ijc.30716
pubmed: 28369882
pmcid: 5520228
Chaturvedi AK (2010) Beyond cervical cancer: burden of other HPV-related cancers among men and women. J Adolesc Health 46(4):S20–S26
doi: 10.1016/j.jadohealth.2010.01.016
pubmed: 20307840
dos Santos Menezes F et al (2021) Global incidence trends in head and neck cancer for HPV-related and-unrelated subsites: a systematic review of population-based studies. Oral Oncol 115:105177
doi: 10.1016/j.oraloncology.2020.105177
Wu J et al (2021) Worldwide trend in human papillomavirus–attributable cancer incidence rates between 1990 and 2012 and Bayesian projection to 2030. Cancer 127(17):3172–3182
doi: 10.1002/cncr.33628
pubmed: 33974715
Bruni L et al (2023) Global and regional estimates of genital human papillomavirus prevalence among men: a systematic review and meta-analysis. Lancet Glob Health 11(9):e1345–e1362
doi: 10.1016/S2214-109X(23)00305-4
pubmed: 37591583
pmcid: 10447222
Wei F et al (2021) Epidemiology of anal human papillomavirus infection and high-grade squamous intraepithelial lesions in 29 900 men according to HIV status, sexuality, and age: a collaborative pooled analysis of 64 studies. Lancet HIV 8(9):e531–e543
doi: 10.1016/S2352-3018(21)00108-9
pubmed: 34339628
pmcid: 8408042
Marra E, Lin C, Clifford GM (2019) Type-specific anal human papillomavirus prevalence among men, according to sexual preference and HIV status: a systematic literature review and meta-analysis. J Infect Dis 219(4):590–598
doi: 10.1093/infdis/jiy556
pubmed: 30239749
D’Souza G et al (2023) Prevalence of oral and blood oncogenic human papillomavirus biomarkers among an enriched screening population: Baseline results of the MOUTH study. Cancer 129(15):2373–2384
doi: 10.1002/cncr.34783
pubmed: 37032449
Riddell, J.t, et al (2022) Oral human papillomavirus prevalence, persistence, and risk-factors in HIV-positive and HIV-negative adults. Tumour Virus Res 13:200237
doi: 10.1016/j.tvr.2022.200237
Morhason-Bello IO et al (2019) Reported oral and anal sex among adolescents and adults reporting heterosexual sex in sub-Saharan Africa: a systematic review. Reprod Health 16(1):48
doi: 10.1186/s12978-019-0722-9
pubmed: 31060573
pmcid: 6501425
Morhason-Bello IO et al (2023) Heterosexual oral and anal sex: perceptions, terminologies, and attitudes of younger and older adults in Ibadan. Nigeria Arch Sex Behav 52(1):161–175
doi: 10.1007/s10508-022-02313-8
pubmed: 36123563
Jedy-Agba EE et al (2016) The burden of HPV associated cancers in two regions in Nigeria 2012–2014. Cancer Epidemiol 45:91–97
doi: 10.1016/j.canep.2016.10.008
pubmed: 27780076
pmcid: 5124511
Morhason-Bello IO et al (2021) Prevalence and genotype specific concordance of oro-genital and anal human papillomavirus infections among sexually active Nigerian women. Infect Agent Cancer 16(1):59
doi: 10.1186/s13027-021-00398-9
pubmed: 34496909
pmcid: 8424803
Morhason-Bello IO et al (2022) Oral, genital and anal human papillomavirus infections among female sex workers in Ibadan, Nigeria. PLoS ONE 17(3):e0265269
doi: 10.1371/journal.pone.0265269
pubmed: 35353833
pmcid: 8967011
Morhason-Bello, I.O., (2021). The epidemiology of, and risk factors for, oro-genital and anal human papillomavirus infections among sexually active Nigerians in Ibadan: a mixed methods study. PhD (research paper style) thesis, London School of Hygiene & Tropical Medicine. https://doi.org/10.17037/PUBS.04659919 .
National Population Commission, Nigeria Data Porta. Available from http://nigeria.opendataforafrica.org/xspplpb/nigeria-census (Accessed 23/09/2019). 2006.
Federal Ministry of Health, National Guidelines on the Syndromic Management of Sexually Transmitted Infections (STIs) and other Reproductive Tract Infections (RTIs). FMOH, Abuja. 2016.
Anyplex II HPV28 Detection. Simultaneous detection and identification of 28 HPV types (Seegene, Seoul, South Korea) assay. https://www.seegene.com/assays/anyplex2_hpv28_detection . Accessed 21 October 2021.
Anyplex™, Anyplex™ II HPV28 Detection Simultaneous detection of 28 HPV types. Available from: http://www.seegene.com/neo/en/products/hpv/anyplex2_HPV28.php (Accessed on 7/07/2017.
Monographs, I., (2007). Human Papillomaviruses. In IARC Monographs on the Evaluation of Carcinogenic Risks to Human Volume 90. IARC, Lyon, France. Available from: https://monographs.iarc.who.int/agents-classified-by-the-iarc/ (accessed 15 March 2024).
Garolla A et al (2023) HPV-related diseases in male patients: an underestimated conundrum. J Endocrinol Invest. https://doi.org/10.1007/s40618-023-02192-3
doi: 10.1007/s40618-023-02192-3
pubmed: 37770654
pmcid: 10859347
Sarier M et al (2023) Evaluation of the optimal sampling approach for HPV genotyping in circumcised heterosexual men with genital warts. J Infect Chemother 29(5):475–480
doi: 10.1016/j.jiac.2023.01.017
pubmed: 36731776
Berenson AB, Hirth JM, Chang M (2021) Prevalence of genital human papillomavirus by age and race/ethnicity among males. Clin Infect Dis 73(9):1625–1633
doi: 10.1093/cid/ciab429
pubmed: 33983416
Kusters JMA et al (2023) Global type-specific genital human papillomavirus prevalence in men, by sexual orientation: a systematic review and meta-analysis. J Infect Dis. https://doi.org/10.1093/infdis/jiad109
doi: 10.1093/infdis/jiad109
pubmed: 37079383
pmcid: 10582913
Wei F et al (2023) Incidence and clearance of anal human papillomavirus infection in 16 164 individuals, according to human immunodeficiency virus status, sex, and male sexuality: an international pooled analysis of 34 longitudinal studies. Clin Infect Dis 76(3):e692–e701
doi: 10.1093/cid/ciac581
pubmed: 35869839
Chikandiwa A et al (2019) Prevalent, persistent anal HPV infection and squamous intraepithelial lesions: findings from a cohort of men living with HIV in South Africa. PLoS ONE 14(12):e0225571
doi: 10.1371/journal.pone.0225571
pubmed: 31805074
pmcid: 6894774
Chinyowa S et al (2018) Anal human papillomavirus infection in HIV-positive men and women at two opportunistic infections clinics in Harare, Zimbabwe. BMC Public Health 18(1):1260
doi: 10.1186/s12889-018-6170-6
pubmed: 30428859
pmcid: 6237038
Chikandiwa A et al (2017) Prevalence of anogenital HPV infection, related disease and risk factors among HIV-infected men in inner-city Johannesburg, South Africa: baseline findings from a cohort study. BMC Public Health 17(Suppl 3):425
doi: 10.1186/s12889-017-4354-0
pubmed: 28832285
pmcid: 5498864
Bettampadi D et al (2020) Oral human papillomavirus prevalence and type distribution by country (Brazil, Mexico and the United States) and age among HPV infection in men study participants. Int J Cancer 146(11):3026–3033
doi: 10.1002/ijc.32713
pubmed: 31583681
Jamieson LM et al (2020) Prevalence of oral human papillomavirus infection among australian indigenous adults. JAMA Netw Open 3(6):e204951
doi: 10.1001/jamanetworkopen.2020.4951
pubmed: 32511719
pmcid: 7280951
Zhu Y et al (2023) Epidemiology of oral human papillomavirus infection among diverse chinese adults in typical areas of china: findings from the DLCC Study. Cancer Epidemiol Biomark Prev 32(11):1635–1643
doi: 10.1158/1055-9965.EPI-23-0626
Vogt SL et al (2013) Concordant oral-genital HPV infection in South Africa couples: evidence for transmission. Front Oncol 3:303
doi: 10.3389/fonc.2013.00303
pubmed: 24377087
pmcid: 3860183
Chikandiwa A et al (2018) Oropharyngeal HPV infection: prevalence and sampling methods among HIV-infected men in South Africa. Int J STD AIDS 29(8):776–780
doi: 10.1177/0956462418755882
pubmed: 29471764
pmcid: 6009177
Simonidesova S et al (2018) The prevalence of oral HPV infection in healthy populations: a systematic review with a focus on European populations. Epidemiol Mikrobiol Imunol 67(4):175–183
pubmed: 30630321
Tsikis S et al (2018) Risk factors, prevalence, and site concordance of human papillomavirus in high-risk Greek men. Eur J Cancer Prev 27(5):514–520
doi: 10.1097/CEJ.0000000000000366
pubmed: 28394804
pmcid: 5631955
Agada, A., (2018). Assessing the human rights implications of the Nigerian law dealing with sexual orientation., University of Pretoria.
Arimoro AE (2019) The criminalisation of consensual same-sex sexual conduct in Nigeria: a critique. J Hum Rights Soc Work 4(4):257–266
doi: 10.1007/s41134-019-00091-3
Strömdahl S et al (2019) An assessment of stigma and human right violations among men who have sex with men in Abuja, Nigeria. BMC Int Health Hum Rights 19:1–7
doi: 10.1186/s12914-019-0190-x
Flesia L et al (2020) Health-related lifestyles, substance-related behaviors, and sexual habits among italian young adult males: an epidemiologic study. Sexual Med 8(3):361–369
doi: 10.1016/j.esxm.2020.03.003
Paquette R et al (2017) Illicit drug use and its association with key sexual risk behaviours and outcomes: findings from Britain’s third National Survey of Sexual Attitudes and Lifestyles (Natsal-3). PLoS ONE 12(5):e0177922
doi: 10.1371/journal.pone.0177922
pubmed: 28542366
pmcid: 5436851
Giuliano AR et al (2023) Oral human papillomavirus prevalence and genotyping among a healthy adult population in the US. JAMA Otolaryngol Head Neck Surg 149(9):783–795
doi: 10.1001/jamaoto.2023.1573
pubmed: 37535349
pmcid: 10401396
Fan KM et al (2023) Rates of oropharyngeal cancer continue to rise steeply amongst Australian men. Oral Dis 29(5):1959–1966
doi: 10.1111/odi.14202
pubmed: 35359030
Sonawane K et al (2023) Prevalence and concordance of oral and genital HPV by sexual orientation among US men. JNCI Cancer Spectr. https://doi.org/10.1093/jncics/pkac088
doi: 10.1093/jncics/pkac088
pubmed: 36519821
Rollo F et al (2021) Concurrent and concordant anal and oral human papillomavirus infections are not associated with sexual behavior in at-risk males. Pathogens. https://doi.org/10.3390/pathogens10101254
doi: 10.3390/pathogens10101254
pubmed: 34832567
pmcid: 8625118
Custer J et al (2021) Concurrent and concordant oral and genital high-risk human papillomavirus in the United States: results from the National Health and Nutrition Examination Survey. J Infect Dis 223(8):1400–1409
doi: 10.1093/infdis/jiaa519
pubmed: 32803235
Liu F et al (2015) Concurrence of oral and genital human papillomavirus infection in healthy men: a population-based cross-sectional study in rural China. Sci Rep 5:15637
doi: 10.1038/srep15637
pubmed: 26503510
pmcid: 4621523
Vergori A et al (2018) Oral human Papillomavirus DNA detection in HIV-positive men: prevalence, predictors, and co-occurrence at anal site. BMC Infect Dis 18(1):25
doi: 10.1186/s12879-017-2937-0
pubmed: 29310590
pmcid: 5759194
van Rijn VM et al (2014) Anal, penile, and oral high-risk HPV infections and HPV seropositivity in HIV-positive and HIV-negative men who have sex with men. PLoS ONE 9(3):e92208
doi: 10.1371/journal.pone.0092208
pubmed: 24651691
pmcid: 3961332
Patel EU et al (2017) Concordance of penile and Oral human papillomavirus infections among men in the United States. J Infect Dis 215(8):1207–2121
doi: 10.1093/infdis/jix116
pubmed: 28329127
pmcid: 5441108