Harnessing the potency of scorpion venom-derived proteins: applications in cancer therapy.
Anticancer agents
Cancer therapy
Drug development
Drug discovery
Peptide therapeutics
SV-derived peptides
Journal
Bioresources and bioprocessing
ISSN: 2197-4365
Titre abrégé: Bioresour Bioprocess
Pays: Germany
ID NLM: 101665551
Informations de publication
Date de publication:
03 Oct 2024
03 Oct 2024
Historique:
received:
15
07
2024
accepted:
10
09
2024
medline:
3
10
2024
pubmed:
3
10
2024
entrez:
3
10
2024
Statut:
epublish
Résumé
Despite breakthroughs in the development of cancer diagnosis and therapy, most current therapeutic approaches lack precise specificity and sensitivity, resulting in damage to healthy cells. Selective delivery of anti-cancer agents is thus an important goal of cancer therapy. Scorpion venom (SV) and/or body parts have been used since early civilizations for medicinal purposes, and in cultures, SV is still applied to the treatment of several diseases including cancer. SV contains numerous active micro and macromolecules with diverse pharmacological effects. These include potent anti-microbial, anti-viral, anti-inflammatory, and anti-cancer properties. This review focuses on the recent advances of SV-derived peptides as promising anti-cancer agents and their diagnostic and therapeutic potential applications in cancers such as glioma, breast cancer, prostate cancer, and colon cancer. Well-characterized SV-derived peptides are thus needed to serve as potent and selective adjuvant therapy for cancer, to significantly enhance the patients' survival and wellbeing.
Identifiants
pubmed: 39361208
doi: 10.1186/s40643-024-00805-0
pii: 10.1186/s40643-024-00805-0
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
93Informations de copyright
© 2024. The Author(s).
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