Capturing a methanogenic carbon monoxide dehydrogenase/acetyl-CoA synthase complex via cryogenic electron microscopy.

Aldehyde Oxidoreductases / metabolism Cryoelectron Microscopy / methods Methanosarcina / enzymology Methane / metabolism Multienzyme Complexes / metabolism Acetate-CoA Ligase / metabolism Carbon Monoxide / metabolism Models, Molecular
cryogenic electron microscopy gas channels greenhouse gases methanogenesis

Journal

Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876

Informations de publication

Date de publication:
08 Oct 2024
Historique:
medline: 4 10 2024
pubmed: 4 10 2024
entrez: 3 10 2024
Statut: ppublish

Résumé

Approximately two-thirds of the estimated one-billion metric tons of methane produced annually by methanogens is derived from the cleavage of acetate. Acetate is broken down by a Ni-Fe-S-containing A-cluster within the enzyme acetyl-CoA synthase (ACS) to carbon monoxide (CO) and a methyl group (CH

Identifiants

DOI: 10.1073/pnas.2410995121 PMID: 39361653
pubmed: 39361653
doi: 10.1073/pnas.2410995121
doi:

Substances chimiques

carbon monoxide dehydrogenase EC 1.2.7.4
Aldehyde Oxidoreductases EC 1.2.-
Methane OP0UW79H66
Multienzyme Complexes 0
Acetate-CoA Ligase EC 6.2.1.1
Carbon Monoxide 7U1EE4V452

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

e2410995121

Subventions

Organisme : Howard Hughes Medical Institute (HHMI)
ID : CLD is an HHMI investigator
Organisme : HHS | National Institutes of Health (NIH)
ID : GM126982

Déclaration de conflit d'intérêts

Competing interests statement:The authors declare no competing interest.

Auteurs

Alison Biester (A)

Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139.
ORCID: 0000-0003-4129-1871

David A Grahame (DA)

Department of Biochemistry and Molecular Biology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814.

Catherine L Drennan (CL)

Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139.
Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139.
HHMI, Massachusetts Institute of Technology, Cambridge, MA 02139.
ORCID: 0000-0001-5486-2755

Articles similaires

Atomic view of photosynthetic metabolite permeability pathways and confinement in synthetic carboxysome shells.

Daipayan Sarkar, Christopher Maffeo, Markus Sutter et al.
1.00
Photosynthesis Ribulose-Bisphosphate Carboxylase Carbon Dioxide Molecular Dynamics Simulation Cyanobacteria

Mouse α-synuclein fibrils are structurally and functionally distinct from human fibrils associated with Lewy body diseases.

Arpine Sokratian, Ye Zhou, Meltem Tatli et al.
1.00
alpha-Synuclein Humans Animals Mice Lewy Body Disease

REliable PIcking by Consensus (REPIC): a consensus methodology for harnessing multiple cryo-EM particle pickers.

Christopher J F Cameron, Sebastian J H Seager, Fred J Sigworth et al.
1.00
Cryoelectron Microscopy Algorithms Image Processing, Computer-Assisted Consensus Software

Mutational analysis of Phanerochaete chrysosporium´s purine transporter.

Mariana Barraco-Vega, Manuel Sanguinetti, Gabriela da Rosa et al.
1.00
Phanerochaete Fungal Proteins Purines Aspergillus nidulans DNA Mutational Analysis

Classifications MeSH

questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Oxidoreductases acting on aldehyde or oxo group donors › Aldehyde oxidoreductases › Capturing a methanogenic carbon monoxide...
questionsmedicales.fr › Techniques d'investigation › Microscopie électronique › Cryomicroscopie électronique › Capturing a methanogenic carbon monoxide...
questionsmedicales.fr › Archéobactéries › Euryarchaeota › Methanosarcinales › Methanosarcinaceae › Methanosarcina › Capturing a methanogenic carbon monoxide...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures acycliques › Alcanes › Méthane › Capturing a methanogenic carbon monoxide...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Complexes multienzymatiques › Capturing a methanogenic carbon monoxide...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Ligases › Carbon-sulfur ligases › Coenzyme A ligases › Acetate coA-ligase › Capturing a methanogenic carbon monoxide...
questionsmedicales.fr › Produits chimiques inorganiques › Composés de l'oxygène › Oxydes › Monoxyde de carbone › Capturing a methanogenic carbon monoxide...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles moléculaires › Capturing a methanogenic carbon monoxide...