Obesity and Hormonal Influences on Asthma: Mechanisms, Management Challenges, and Emerging Therapeutic Strategies.

androgens asthma diabetes diabetes mellitus estrogen hyperthyroidism hypothyroidism insulin resistance l-arginine metabolic syndrome obesity polyunsaturated fatty acid testosterone

Journal

The Journal of allergy and clinical immunology
ISSN: 1097-6825
Titre abrégé: J Allergy Clin Immunol
Pays: United States
ID NLM: 1275002

Informations de publication

Date de publication:
01 Oct 2024
Historique:
received: 27 06 2024
revised: 13 08 2024
accepted: 13 09 2024
medline: 4 10 2024
pubmed: 4 10 2024
entrez: 3 10 2024
Statut: aheadofprint

Résumé

Obesity and hormonal dysregulation, common comorbidities of asthma, not only influence asthma risk and onset but can also complicate its management. The pathobiological characteristics of obesity, such as insulin resistance and metabolism alterations, can impact lung function and airway inflammation while highlighting potential opportunities for therapeutic intervention. Likewise, obesity alters immune cell phenotypes and corticosteroid pharmacokinetics. Hormones such as sex hormones, incretins, and thyroid hormones can also affect asthma. This review highlights the mechanisms underlying obesity-related asthma and hormonal pathologies while exploring potential therapeutic strategies and the need for more research and innovative approaches in managing these comorbid conditions.

Identifiants

DOI: 10.1016/j.jaci.2024.09.018 PMID: 39362350
pubmed: 39362350
pii: S0091-6749(24)00992-8
doi: 10.1016/j.jaci.2024.09.018
pii:
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

Copyright © 2024. Published by Elsevier Inc.

Auteurs

Natalia Weare-Regales (N)

Division of Endocrinology, Diabetes, and Metabolism, Department of Internal Medicine, University of South Florida, Morsani College of Medicine, Tampa, FL, USA; Division of Endocrinology, Department of Internal Medicine, James A. Haley Veterans Administration, Tampa, FL, USA. Electronic address: natalia.weare-regales@va.gov.

Tara Carr (T)

Asthma and Airway Disease Research Center, University of Arizona, Tucson, Arizona; Section of Allergy and Immunology, Department of Medicine, University of Arizona College of Medicine, Tucson, Arizona.

Fernando Holguin (F)

Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado Medical School, Aurora, Colorado, USA.

Christopher Andrew Tibbitt (CA)

Department of Medicine Huddinge, Centre for Infectious Medicine, Karolinska Institutet, Stockholm, Sweden; Clinical Lung and Allergy Research Medical Unit for Lung and Allergy Diseases, Karolinska University Hospital, Stockholm, Sweden.

Richard F Lockey (RF)

Division of Allergy and Immunology, Department of Internal Medicine, University of South Florida, Morsani College of Medicine, Tampa, FL, USA.

Classifications MeSH