Vaginal host response to polycarbonate urethane, an alternative material for the repair of pelvic organ prolapse.

Complications following surgical repair of pelvic organ prolapse (POP) with polypropylene mesh (PPM) are common. Recent data attributes complications, in part, to stiffness mismatches between the vagina and PPM. We developed a 3D printed elastomeric membrane (EM) from a softer polymer, polycarbonate urethane (PCU). EMs were manufactured with more material given the low inherent material strength of PCU. We hypothesized that the EMs would be associated with an improved host response as compared to PPM. A secondary goal was to optimize the material distribution (fiber width and device thickness) within EMs, in regards to the host response. EM constructs (2×1cm

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Déclaration de conflit d'intérêts

Declaration of interests The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: We would like to draw the attention of the Editor to the following facts which may be considered as potential declaration of interests: Pamela Moalli reports equipment, drugs, or supplies was provided by Coloplast Corp. Katrina Knight reports financial support was provided by Magee-Womens Research Institute & Foundation. Pamela Moalli reports a relationship with Hologic Inc that includes board membership. However, there has been no significant financial support for this work that could have influenced its outcome. Additionally, Pamela Moalli is an Associate Editor for the following journals: Urogynecology and Female Urology (Frontiers in Urology).