Phasic perfusion dynamics among migraine subtypes: a multimodel arterial spin labeling investigation.
Arterial spin labeling (ASL)
Cerebral blood flow (CBF)
Headache frequency
Ictal
Magnetic resonance imaging (MRI)
Migraine
Journal
The journal of headache and pain
ISSN: 1129-2377
Titre abrégé: J Headache Pain
Pays: England
ID NLM: 100940562
Informations de publication
Date de publication:
03 Oct 2024
03 Oct 2024
Historique:
received:
23
08
2024
accepted:
27
09
2024
medline:
4
10
2024
pubmed:
4
10
2024
entrez:
3
10
2024
Statut:
epublish
Résumé
Migraine-related perfusion changes are documented but inconsistent across studies due to limited sample size and insufficient phenotyping. The phasic and spatial dynamics across migraine subtypes remains poorly characterized. This study aimed to determine spatiotemporal dynamics of gray matter (GM) perfusion in migraine. We prospectively recruited episodic (EM) and chronic migraine (CM) patients, diagnosed with the International Headache Society criteria and healthy controls (HCs) between 2021 and 2023 from the headache center in a tertiary medical center, and adjacent communities. Magnetic resonance (3-tesla) arterial spin labeling (ASL) was conducted for whole brain cerebral blood flow (CBF) in all participants. The voxel-wise and whole brain gray matter (GM) CBF were compared between subgroups. Spatial pattern analysis of CBF and its correlations with headache frequency were investigated regarding different migraine phases and subtypes. Sex- and age-adjusted voxel-wise and whole brain GM comparisons were performed between HCs and different EM and CM phases. Spatial pattern analysis was conducted by CBF clusters with phasic differences and spin permutation test. Correlations between headache frequency and CBF were investigated regarding different EM and CM phases. Totally 344 subjects (172 EM, 120 CM, and 52 HCs) were enrolled. Higher CBF in different anatomical locations was identified in ictal EM and CM. The combined panels of the specific locations with altered CBF in ictal EM on receiver operating characteristic curve analysis demonstrated areas under curve of 0.780 (vs. HCs) and 0.811 (vs. preictal EM). The spatial distribution of ictal-interictal CBF alteration of EM and CM were not correlated with each other (p = 0.665; r = - 0.018). Positive correlations between headache frequency and CBF were noted in ictal EM and CM regarding whole GM and specific anatomical locations. Patients with migraine exhibited unique spatiotemporal CBF dynamics across different phases and distinct between subtypes. The findings provide neurobiological insights into how selected anatomical structures engage in a migraine attack and adapt to plastic change of repeated attacks along with chronicity.
Sections du résumé
BACKGROUND
BACKGROUND
Migraine-related perfusion changes are documented but inconsistent across studies due to limited sample size and insufficient phenotyping. The phasic and spatial dynamics across migraine subtypes remains poorly characterized. This study aimed to determine spatiotemporal dynamics of gray matter (GM) perfusion in migraine.
METHODS
METHODS
We prospectively recruited episodic (EM) and chronic migraine (CM) patients, diagnosed with the International Headache Society criteria and healthy controls (HCs) between 2021 and 2023 from the headache center in a tertiary medical center, and adjacent communities. Magnetic resonance (3-tesla) arterial spin labeling (ASL) was conducted for whole brain cerebral blood flow (CBF) in all participants. The voxel-wise and whole brain gray matter (GM) CBF were compared between subgroups. Spatial pattern analysis of CBF and its correlations with headache frequency were investigated regarding different migraine phases and subtypes. Sex- and age-adjusted voxel-wise and whole brain GM comparisons were performed between HCs and different EM and CM phases. Spatial pattern analysis was conducted by CBF clusters with phasic differences and spin permutation test. Correlations between headache frequency and CBF were investigated regarding different EM and CM phases.
RESULTS
RESULTS
Totally 344 subjects (172 EM, 120 CM, and 52 HCs) were enrolled. Higher CBF in different anatomical locations was identified in ictal EM and CM. The combined panels of the specific locations with altered CBF in ictal EM on receiver operating characteristic curve analysis demonstrated areas under curve of 0.780 (vs. HCs) and 0.811 (vs. preictal EM). The spatial distribution of ictal-interictal CBF alteration of EM and CM were not correlated with each other (p = 0.665; r = - 0.018). Positive correlations between headache frequency and CBF were noted in ictal EM and CM regarding whole GM and specific anatomical locations.
CONCLUSIONS
CONCLUSIONS
Patients with migraine exhibited unique spatiotemporal CBF dynamics across different phases and distinct between subtypes. The findings provide neurobiological insights into how selected anatomical structures engage in a migraine attack and adapt to plastic change of repeated attacks along with chronicity.
Identifiants
pubmed: 39363159
doi: 10.1186/s10194-024-01880-6
pii: 10.1186/s10194-024-01880-6
doi:
Substances chimiques
Spin Labels
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
167Subventions
Organisme : Taipei Veterans General Hospital
ID : V113C-120, V113E004-1, V112C-113 & V112E-004-1 (to SJW); V112D67-001-MY3-2 & V113C-058 (to SPC); V112B-007 (to CHW)
Organisme : Taipei Veterans General Hospital
ID : V113C-120, V113E004-1, V112C-113 & V112E-004-1 (to SJW); V112D67-001-MY3-2 & V113C-058 (to SPC); V112B-007 (to CHW)
Organisme : Taipei Veterans General Hospital
ID : V113C-120, V113E004-1, V112C-113 & V112E-004-1 (to SJW); V112D67-001-MY3-2 & V113C-058 (to SPC); V112B-007 (to CHW)
Organisme : Yen Tjing Ling Medical Foundation
ID : CI-112-2 (to CHW)
Organisme : Professor Tsuen CHANG's Scholarship Program from Medical Scholarship Foundation In Memory Of Professor Albert Ly-Young Shen
ID : N/A
Organisme : Vivian W. Yen Neurological Foundation
ID : N/A
Organisme : Yin Shu-Tien Foundation Taipei Veterans General Hospital-National Yang Ming Chiao Tung University Excellent Physician Scientists Cultivation Program
ID : No.112-V-B-039; No. 113-V-B-020 (to CHW)
Organisme : National Science and Technology Council
ID : NSTC 108-2314-B-010-022 -MY3, 110-2326-B-A49A-501-MY3 & 112-2314-B-A49-037-MY3 (to SPC); 110-2321-B-010-005-, 111-2321-B-A49-004, 111-2321-B-A49-011, 111-2314-B-A49-069-MY3, 111-2314-B-075-086-MY3, 111-2314-B-A49-090-MY3 & 112-2321-B-075-007 (to SJW); 113-2314-B-A49-070- & 112-2314-B-A49-056- (to KHC); 111-2314-B-075-025 -MY3 & 110-2314-B-075-005 (to CHW)
Organisme : National Science and Technology Council
ID : NSTC 108-2314-B-010-022 -MY3, 110-2326-B-A49A-501-MY3 & 112-2314-B-A49-037-MY3 (to SPC); 110-2321-B-010-005-, 111-2321-B-A49-004, 111-2321-B-A49-011, 111-2314-B-A49-069-MY3, 111-2314-B-075-086-MY3, 111-2314-B-A49-090-MY3 & 112-2321-B-075-007 (to SJW); 113-2314-B-A49-070- & 112-2314-B-A49-056- (to KHC); 111-2314-B-075-025 -MY3 & 110-2314-B-075-005 (to CHW)
Organisme : National Science and Technology Council
ID : NSTC 108-2314-B-010-022 -MY3, 110-2326-B-A49A-501-MY3 & 112-2314-B-A49-037-MY3 (to SPC); 110-2321-B-010-005-, 111-2321-B-A49-004, 111-2321-B-A49-011, 111-2314-B-A49-069-MY3, 111-2314-B-075-086-MY3, 111-2314-B-A49-090-MY3 & 112-2321-B-075-007 (to SJW); 113-2314-B-A49-070- & 112-2314-B-A49-056- (to KHC); 111-2314-B-075-025 -MY3 & 110-2314-B-075-005 (to CHW)
Organisme : National Science and Technology Council
ID : NSTC 108-2314-B-010-022 -MY3, 110-2326-B-A49A-501-MY3 & 112-2314-B-A49-037-MY3 (to SPC); 110-2321-B-010-005-, 111-2321-B-A49-004, 111-2321-B-A49-011, 111-2314-B-A49-069-MY3, 111-2314-B-075-086-MY3, 111-2314-B-A49-090-MY3 & 112-2321-B-075-007 (to SJW); 113-2314-B-A49-070- & 112-2314-B-A49-056- (to KHC); 111-2314-B-075-025 -MY3 & 110-2314-B-075-005 (to CHW)
Organisme : Brain Research Center, National Yang Ming Chiao Tung University from The Featured Areas Research Center Program within the framework of the Higher Education Sprout Project by the Ministry of Education (MOE) in Taiwan
ID : N/A
Organisme : Brain Research Center, National Yang Ming Chiao Tung University from The Featured Areas Research Center Program within the framework of the Higher Education Sprout Project by the Ministry of Education (MOE) in Taiwan
ID : N/A
Organisme : Ministry of Health and Welfare
ID : MOHW107-TDU-B-211-123001, MOHW 108-TDU-B-211-133001 and MOHW112-TDU-B-211-144001
Organisme : Veterans General Hospitals and University System of Taiwan Joint Research Program
ID : VGHUST-112-G1-2-1 (to SJW)
Informations de copyright
© 2024. The Author(s).
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