Development of a Preclinical Double Model of Mandibular Irradiated Bone and Osteoradionecrosis in New Zealand Rabbits.
experimental animal models
head and neck
mandibular irradiation
osteoradionecrosis
radiotherapy
Journal
Head & neck
ISSN: 1097-0347
Titre abrégé: Head Neck
Pays: United States
ID NLM: 8902541
Informations de publication
Date de publication:
03 Oct 2024
03 Oct 2024
Historique:
revised:
12
09
2024
received:
02
07
2024
accepted:
21
09
2024
medline:
4
10
2024
pubmed:
4
10
2024
entrez:
4
10
2024
Statut:
aheadofprint
Résumé
Radiotherapy (RT) plays a crucial role in head and neck (HN) cancer treatment. Nevertheless, it can lead to serious and challenging adverse events such as osteoradionecrosis (ORN). A preclinical rabbit model of irradiated bone and ORN is herein proposed, with the aim to develop a viable model to be exploited for investigating new therapeutic approaches. Nine New Zealand white rabbits were irradiated using a single beam positioned to the left of the mandible and directed perpendicular to the left mandible. A 10 × 10 mm Radiological signs suggestive for ORN were detected in the entire population (100%) 16 weeks after irradiation on ROI A preclinical double model was successfully developed. The side receiving the higher dose showed radiological and histological signs of bone damage, resulting in an ORN model. Whereas the contralateral side, receiving the lower dose, presented with histological damage only and a normal radiological appearance. This work describes the creation of a double model, an ORN and irradiated bone model, for further study using this animal species.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Princess Margaret Cancer Foundation
Informations de copyright
Head & Neck© 2024 The Author(s). Head & Neck published by Wiley Periodicals LLC.
Références
G. Delaney, S. Jacob, C. Featherstone, and M. Barton, “The Role of Radiotherapy in Cancer Treatment,” Cancer 104, no. 6 (2005): 1129–1137, https://doi.org/10.1002/cncr.21324.
“Guidelines Detail,” NCCN, accessed October 30, 2023, https://www.nccn.org/guidelines/guidelines‐detail.
J. A. Langendijk, P. Doornaert, I. M. Verdonck‐de Leeuw, C. R. Leemans, N. K. Aaronson, and B. J. Slotman, “Impact of Late Treatment‐Related Toxicity on Quality of Life Among Patients With Head and Neck Cancer Treated With Radiotherapy,” Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology 26, no. 22 (2008): 3770–3776, https://doi.org/10.1200/JCO.2007.14.6647.
D. J. Toneatti, R. R. Graf, J. P. Burkhard, and B. Schaller, “Survival of Dental Implants and Occurrence of Osteoradionecrosis in Irradiated Head and Neck Cancer Patients: A Systematic Review and Meta‐Analysis,” Clinical Oral Investigations 25, no. 10 (2021): 5579–5593, https://doi.org/10.1007/s00784‐021‐04065‐6.
A. Chronopoulos, T. Zarra, M. Ehrenfeld, and S. Otto, “Osteoradionecrosis of the Jaws: Definition, Epidemiology, Staging and Clinical and Radiological Findings. A Concise Review,” International Dental Journal 68, no. 1 (2018): 22–30, https://doi.org/10.1111/idj.12318.
H. Y. Sroussi, J. B. Epstein, R. Bensadoun, et al., “Common Oral Complications of Head and Neck Cancer Radiation Therapy: Mucositis, Infections, Saliva Change, Fibrosis, Sensory Dysfunctions, Dental Caries, Periodontal Disease, and Osteoradionecrosis,” Cancer Medicine 6, no. 12 (2017): 2918–2931, https://doi.org/10.1002/cam4.1221.
J. J. Thorn, H. S. Hansen, L. Specht, and L. Bastholt, “Osteoradionecrosis of the Jaws: Clinical Characteristics and Relation to the Field of Irradiation,” Journal of Oral and Maxillofacial Surgery 58, no. 10 (2000): 1088–1093, https://doi.org/10.1053/joms.2000.9562.
A. J. Frankart, M. J. Frankart, B. Cervenka, A. L. Tang, D. G. Krishnan, and V. Takiar, “Osteoradionecrosis: Exposing the Evidence Not the Bone,” International Journal of Radiation Oncology, Biology, Physics 109, no. 5 (2021): 1206–1218, https://doi.org/10.1016/j.ijrobp.2020.12.043.
A. Lyons and N. Ghazali, “Osteoradionecrosis of the Jaws: Current Understanding of Its Pathophysiology and Treatment,” British Journal of Oral & Maxillofacial Surgery 46, no. 8 (2008): 653–660, https://doi.org/10.1016/j.bjoms.2008.04.006.
R. E. Marx, “Osteoradionecrosis: A New Concept of Its Pathophysiology,” Journal of Oral and Maxillofacial Surgery 41, no. 5 (1983): 283–288, https://doi.org/10.1016/0278‐2391(83)90294‐X.
I. Meyer, “Infectious Diseases of the Jaws,” Journal of Oral Surgery 28, no. 1 (1970): 17–26.
S. Delanian and J. L. Lefaix, “The Radiation‐Induced Fibroatrophic Process: Therapeutic Perspective via the Antioxidant Pathway,” Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology 73, no. 2 (2004): 119–131, https://doi.org/10.1016/j.radonc.2004.08.021.
K. T. Fitzgerald, C. Lyons, A. England, et al., “Risk Factors Associated With the Development of Osteoradionecrosis (ORN) in Head and Neck Cancer Patients in Ireland: A 10‐Year Retrospective Review,” Radiotherapy and Oncology 196 (2024): 196, https://doi.org/10.1016/j.radonc.2024.110286.
M. Renouf, S. Auger, L. Campion, et al., “Prognostic Factors of Mandibular Osteoradionecrosis Including Accurate Colocalization of Avulsions and Dosimetric Dental Mapping Software, a Case‐Control Study,” International Journal of Radiation Oncology, Biology, Physics 120, no. 3 (2024): 783–795, https://doi.org/10.1016/j.ijrobp.2024.04.019.
L. Merring‐Mikkelsen, M. H. Brincker, M. Andersen, Ö. Kesmez, and M. S. Nielsen, “Mandible Osteoradionecrosis After High‐Dose Radiation Therapy for Head and Neck Cancers: Risk Factors and Dosimetric Analysis,” Acta Oncologica 63 (2024): 273–276, https://doi.org/10.2340/1651‐226X.2024.35222.
F. De Felice, V. Tombolini, D. Musio, and A. Polimeni, “Radiation Therapy and Mandibular Osteoradionecrosis: State of the Art,” Current Oncology Reports 22, no. 9 (2020): 89, https://doi.org/10.1007/s11912‐020‐00954‐3.
N. Rice, I. Polyzois, K. Ekanayake, O. Omer, and L. F. A. Stassen, “The Management of Osteoradionecrosis of the Jaws—A Review,” Surgeon: Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland 13, no. 2 (2015): 101–109, https://doi.org/10.1016/j.surge.2014.07.003.
L. Park, N. Lilic, B. Addison, and R. Patel, “Cost Analysis of Osteoradionecrosis,” Journal of Laryngology and Otology 131, no. 4 (2017): 303–308, https://doi.org/10.1017/S0022215116009956.
C. Zong, B. Cai, X. Wen, et al., “The Role of Myofibroblasts in the Development of Osteoradionecrosis in a Newly Established Rabbit Model,” Journal of Cranio‐Maxillofacial Surgery 44, no. 6 (2016): 725–733, https://doi.org/10.1016/j.jcms.2016.03.002.
M. Bazalova and E. E. Graves, “The Importance of Tissue Segmentation for Dose Calculations for Kilovoltage Radiation Therapy: Tissue Segmentation for Kilovoltage Radiotherapy,” Medical Physics 38, no. 6 (2011): 3039–3049, https://doi.org/10.1118/1.3589138.
S. S. Deshpande, M. H. Thakur, K. Dholam, A. Mahajan, S. Arya, and S. Juvekar, “Osteoradionecrosis of the Mandible: Through a radiologist's Eyes,” Clinical Radiology 70, no. 2 (2015): 197–205, https://doi.org/10.1016/j.crad.2014.09.012.
G. Granström, “Osseointegration in Irradiated Cancer Patients: An Analysis With Respect to Implant Failures,” Journal of Oral and Maxillofacial Surgery 63, no. 5 (2005): 579–585, https://doi.org/10.1016/j.joms.2005.01.008.
J. Bras, H. K. T. De Jonge, and J. P. R. Van Merkesteyn, “Osteoradioinecrosis of the Mandible: Pathogenesis,” American Journal of Otolaryngology 11, no. 4 (1990): 244–250, https://doi.org/10.1016/0196‐0709(90)90084‐9.
M. Ferrari, S. Taboni, H. H. L. Chan, et al., “Hydrogel‐Chitosan and Polylactic Acid‐Polycaprolactone Bioengineered Scaffolds for Reconstruction of Mandibular Defects: A Preclinical In Vivo Study With Assessment of Translationally Relevant Aspects,” Frontiers in Bioengineering and Biotechnology 15, no. 12 (2024): 1353523, https://doi.org/10.3389/fbioe.2024.1353523.
I. Miyamoto, R. Tanaka, S. Kogi, et al., “Clinical Diagnostic Imaging Study of Osteoradionecrosis of the Jaw: A Retrospective Study,” Journal of Clinical Medicine 10, no. 20 (2021): 4704, https://doi.org/10.3390/jcm10204704.
B. Yilmaz, E. Somay, A. Kucuk, B. Pehlivan, U. Selek, and E. Topkan, “Challenges in the Radiological Diagnosis of Osteoradionecrosis of the Jaw in Head and Neck Cancer Patients,” in Advancements in Cancer Research, ed. C. M. Sergi (Brisbane, AU: Exon Publications, 2023), https://www.ncbi.nlm.nih.gov/books/NBK594964/.
J. M. Gowgiel, “Experimental Radio‐Osteonecrosis of the Jaws,” Journal of Dental Research 39, no. 1 (1960): 176–197, https://doi.org/10.1177/00220345600390011401.
L. J. Poort, J. H. B. Ludlage, N. Lie, et al., “The Histological and Histomorphometric Changes in the Mandible After Radiotherapy: An Animal Model,” Journal of Cranio‐Maxillofacial Surgery 45, no. 5 (2017): 716–721, https://doi.org/10.1016/j.jcms.2017.02.014.
J. A. Chen, C. C. Wang, Y. K. Wong, et al., “Osteoradionecrosis of Mandible Bone in Patients With Oral Cancer—Associated Factors and Treatment Outcomes,” Head & Neck 38, no. 5 (2016): 762–768, https://doi.org/10.1002/hed.23949.
J. B. Epstein, F. L. Wong, and P. Stevenson‐Moore, “Osteoradionecrosis: Clinical Experience and a Proposal for Classification,” Journal of Oral and Maxillofacial Surgery: Official Journal of the American Association of Oral and Maxillofacial Surgeons 45, no. 2 (1987): 104–110, https://doi.org/10.1016/0278‐2391(87)90399‐5.
A. A. Owosho, A. Kadempour, S. K. Yom, et al., “Radiographic Osteoradionecrosis of the Jaw With Intact Mucosa: Proposal of Clinical Guidelines for Early Identification of This Condition,” Oral Oncology 51, no. 12 (2015): e93–e96, https://doi.org/10.1016/j.oraloncology.2015.09.009.
G. Støre and M. Boysen, “Mandibular Osteoradionecrosis: Clinical Behaviour and Diagnostic Aspects,” Clinical Otolaryngology and Allied Sciences 25, no. 5 (2000): 378–384, https://doi.org/10.1046/j.1365‐2273.2000.00367.x.
P. Bléry, F. Espitalier, A. Hays, et al., “Development of Mandibular Osteoradionecrosis in Rats: Importance of Dental Extraction,” Journal of Cranio‐Maxillofacial Surgery 43, no. 9 (2015): 1829–1836, https://doi.org/10.1016/j.jcms.2015.08.016.
R. S. Jackson, S. G. Voss, Z. C. Wilson, et al., “An Athymic Rat Model for Mandibular Osteoradionecrosis Allowing for Direct Translation of Regenerative Treatments,” Otolaryngology—Head and Neck Surgery: Official Journal of American Academy of Otolaryngology‐Head and Neck Surgery 153, no. 4 (2015): 526–531, https://doi.org/10.1177/0194599815593278.
N. Muhanna, C. M. Douglas, H. H. L. Chan, et al., “Rabbit VX2 Head and Neck Squamous Cell Models for Translational Head and Neck Theranostic Technology Development,” Clinical and Translational Medicine 11, no. 10 (2021): e550, https://doi.org/10.1002/ctm2.550.
M. Fenner, J. Park, N. Schulz, et al., “Validation of Histologic Changes Induced by External Irradiation in Mandibular Bone. An Experimental Animal Model,” Journal of Cranio‐Maxillofacial Surgery 38, no. 1 (2010): 47–53, https://doi.org/10.1016/j.jcms.2009.07.011.
G. Wu, L. Chen, T. Qu, G. Zhu, Y. Wang, and C. Zhu, “Ultrasonic Treatment of Canine ORNM,” Journal of Oral and Maxillofacial Surgery 71, no. 1 (2013): 199–207, https://doi.org/10.1016/j.joms.2012.03.034.
J. Xu, Z. Zheng, D. Fang, et al., “Early‐Stage Pathogenic Sequence of Jaw Osteoradionecrosis In Vivo,” Journal of Dental Research 91, no. 7 (2012): 702–708, https://doi.org/10.1177/0022034512448661.
A. Paredes, M. Lindeblad, R. Patil, et al., “The New Zealand White Rabbit Animal Model of Acute Radiation Syndrome: Hematopoietic and Coagulation‐Based Parameters by Radiation Dose Following Supportive Care,” International Journal of Radiation Biology 97, no. 1 (2021): S45–S62, https://doi.org/10.1080/09553002.2020.1820606.
M. M. Abu‐Serriah, D. A. McGowan, K. F. Moos, and J. Bagg, “Extra‐Oral Craniofacial Endosseous Implants and Radiotherapy,” International Journal of Oral and Maxillofacial Surgery 32, no. 6 (2003): 585–592, https://doi.org/10.1054/ijom.2003.0429.
B. L. Eppley, D. T. Connolly, T. Winkelmann, A. M. Sadove, D. Heuvelman, and J. Feder, “Free Bone Graft Reconstruction of Irradiated Facial Tissue: Experimental Effects of Basic Fibroblast Growth Factor Stimulation,” Plastic and Reconstructive Surgery 88, no. 1 (1991): 1–11, https://doi.org/10.1097/00006534‐199107000‐00001.
J. Xu, Z. Zheng, D. Fang, et al., “Mesenchymal Stromal Cell‐Based Treatment of Jaw Osteoradionecrosis in Swine,” Cell Transplantation 21, no. 8 (2012): 1679–1686, https://doi.org/10.3727/096368911X637434.
B. R. Chrcanovic, P. Reher, A. A. Sousa, and M. Harris, “Osteoradionecrosis of the Jaws—A Current Overview—Part 1,” Oral and Maxillofacial Surgery 14, no. 1 (2010): 3–16, https://doi.org/10.1007/s10006‐009‐0198‐9.
E. Topkan, A. Kucuk, E. Somay, B. Yilmaz, B. Pehlivan, and U. Selek, “Review of Osteoradionecrosis of the Jaw: Radiotherapy Modality, Technique, and Dose as Risk Factors,” Journal of Clinical Medicine 12, no. 8 (2023): 3025, https://doi.org/10.3390/jcm12083025.
T. Reuther, T. Schuster, U. Mende, and A. Kübler, “Osteoradionecrosis of the Jaws as a Side Effect of Radiotherapy of Head and Neck Tumour Patients—A Report of a Thirty Year Retrospective Review,” International Journal of Oral and Maxillofacial Surgery 32, no. 3 (2003): 289–295, https://doi.org/10.1054/ijom.2002.0332.