Efficacy of Potassium Iodide and Glutathione for Correlation of Dentin Discoloration Caused by Silver Diamine Fluoride.

 This study aimed to investigate and contrast the degree of dentin discoloration resulting from the application of silver diamine fluoride (SDF) alone, SDF in combination with potassium iodide (KI), and SDF in combination with glutathione. The aim was to assess the effectiveness of these combinations in reducing the aesthetic issues associated with SDF treatment in minimally invasive dentistry and preventive procedures. We conducted this in-vitro study on 136 permanent molar teeth. The teeth were randomly assigned to two main groups of total-etch and self-etch and four subgroups of control, SDF, SDF plus KI, and SDF with glutathione. The teeth underwent colorimetry before and 1 week after applying materials to compare the color change. We mounted the teeth in acrylic resin 1 mm below their cementoenamel junction. A low-speed diamond saw and 600-grit silicon carbide abrasive paper eliminated the occlusal enamel for 10 seconds under water coolant, exposing the dentin. The teeth were then immersed in a demineralizing solution (pH of 4.4, 50 mmol acetate, 2.2 mmol potassium dihydrogen phosphate, and 2.2 mmol calcium chloride) for 7 days at 37°C to induce dentin demineralization and simulate demineralized dentin artificially. The teeth were then gently polished with 600-grit silicon carbide abrasive paper to create a standard smear layer and eliminate the demineralized dentin layer. 136 teeth were evaluated in the total-etch (n = 68) and self-etch (n = 68) groups. Glutathione and KI significantly decreased the discoloration caused by SDF (P<0.05). No significant difference was noted in color change between SDF/glutathione and SDF plus KI groups (P > 0.05). In self-etch groups, glutathione yielded an ∆E=4.12, while KI yielded an ∆E=4.44, with no significant difference. The application of glutathione and KI can significantly decrease dentin discoloration caused by SDF.

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Human subjects: Consent was obtained or waived by all participants in this study. Ahvaz Jundishapur University of Medical Sciences Ethics Committee issued approval IR.AJUMS.REC.1399.605. The ethics committee of Ahvaz Jundishapur University of Medical Sciences approved the study (IR.AJUMS.REC.1399.605). Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work.