Psilocybin reduces functional correlation and the encoding of spatial information by neurons in mouse retrosplenial cortex.
ketanserin
mutual information
psychedelics
retrosplenial cortex
serotonin
Journal
The European journal of neuroscience
ISSN: 1460-9568
Titre abrégé: Eur J Neurosci
Pays: France
ID NLM: 8918110
Informations de publication
Date de publication:
04 Oct 2024
04 Oct 2024
Historique:
revised:
31
07
2024
received:
07
03
2024
accepted:
18
09
2024
medline:
4
10
2024
pubmed:
4
10
2024
entrez:
4
10
2024
Statut:
aheadofprint
Résumé
Psychedelic drugs have profound effects on perception, cognition and mood. How psychedelics affect neural signaling to produce these effects remains poorly understood. We investigated the effect of the classic psychedelic psilocybin on neural activity patterns and spatial encoding in the retrosplenial cortex of head-fixed mice navigating on a treadmill. The place specificity of neurons to distinct locations along the belt was reduced by psilocybin. Moreover, the stability of place-related activity across trials decreased. Psilocybin also reduced the functional correlation among simultaneously recorded neurons. The 5-HT
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Natural Sciences and Engineering Research Council of Canada
Organisme : New Frontiers in Research Fund
Organisme : Alberta Innovates
Organisme : Beswick Fellowship
Organisme : CIHR
Pays : Canada
Organisme : Research Alliance of Canada
Informations de copyright
© 2024 The Author(s). European Journal of Neuroscience published by Federation of European Neuroscience Societies and John Wiley & Sons Ltd.
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