GD2 and GD3 gangliosides as prognostic biomarkers in high grade serous ovarian cancer.

Gangliosides GD2 and GD3 have been proposed to be of significance in diagnosis of ovarian masses. We aim to study serum GD2 and GD3 gangliosides as predictors of oncological outcomes among high grade serous (HGS) ovarian cancer (OC). A retrospective study including biobanked serum samples of HGS OC treated between 2005-2016. Serum GD2 and GD3 concentrations were quantified using indirect ELISA and analyzed with respect to survival. Sixty patients were included. Patients with GD3>12.8ng/mL had shorter PFS when compared to patients with lower level; median 31 vs. 67 months, p =.005. Patients with GD2> 7.1ng/mL had shorter median PFS than those with lower level of (23 vs. 52 months, p =.024.) Patients with GD3>14.5ng/mL had shorter OS vs. patients with lower level (median 31 vs. 70 months, p =.002). In a Cox regression, following adjustment for age, CA-125, disease stage and age, serum elevated GD3 was independently associated with short PFS (adjusted hazard ratio 2.0, 95% CI 1.1-3.8, p=.024). In a separate Cox regression, elevated GD2 was independently associated with PFS (adjusted hazard ratio3.0 (1.2-7.7). p=.019. High serum GD3 and GD2 were independently associated with short OS as well. High levels of serum GD2 and GD3 in HGS OC were associated with shorter PFS and OS. GD3 is superior to GD2 as a biomarker for prognosis.

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Declaration of competing interest None declared.