Intima media thickness of the carotid artery in primary antiphospholipid syndrome: A systematic review and meta-analysis.

Atherosclerosis Intima media thickness Primary antiphospholipid syndrome

Journal

Autoimmunity reviews
ISSN: 1873-0183
Titre abrégé: Autoimmun Rev
Pays: Netherlands
ID NLM: 101128967

Informations de publication

Date de publication:
02 Oct 2024
Historique:
received: 30 05 2024
revised: 01 10 2024
accepted: 01 10 2024
medline: 5 10 2024
pubmed: 5 10 2024
entrez: 4 10 2024
Statut: aheadofprint

Résumé

Primary antiphospholipid syndrome (PAPS) has been associated with an increase in clinical events associated with atherosclerotic vascular disease. Intima media thickness (IMT) of carotid arteries is a surrogate marker of atherosclerotic vascular disease. To conduct a systematic review and meta-analysis of studies evaluating IMT and their clinical correlated in PAPS. Systematic search of EMBASE and PubMed databases from January 2000 to December 2023; we employed random effect meta-analyses for continuous outcomes and Peto's odds ratio for rare events. The meta-analysis included 21 studies (20 case control and 1 cohort) showing that PAPS patients (n = 1103) had thicker IM than controls (n = 832) (p < 0.0001) with wide heterogeneity (I Atherosclerosis of the carotid artery represents a clinical feature of PAPS in relation to the traditional risk factors and to statin use. Minimising the atherogenic risk with statins could reduce the late arterial atherothrombotic risks of PAPS.

Sections du résumé

BACKGROUND BACKGROUND
Primary antiphospholipid syndrome (PAPS) has been associated with an increase in clinical events associated with atherosclerotic vascular disease. Intima media thickness (IMT) of carotid arteries is a surrogate marker of atherosclerotic vascular disease.
OBJECTIVES OBJECTIVE
To conduct a systematic review and meta-analysis of studies evaluating IMT and their clinical correlated in PAPS.
METHODS METHODS
Systematic search of EMBASE and PubMed databases from January 2000 to December 2023; we employed random effect meta-analyses for continuous outcomes and Peto's odds ratio for rare events.
RESULTS RESULTS
The meta-analysis included 21 studies (20 case control and 1 cohort) showing that PAPS patients (n = 1103) had thicker IM than controls (n = 832) (p < 0.0001) with wide heterogeneity (I
CONCLUSION CONCLUSIONS
Atherosclerosis of the carotid artery represents a clinical feature of PAPS in relation to the traditional risk factors and to statin use. Minimising the atherogenic risk with statins could reduce the late arterial atherothrombotic risks of PAPS.

Identifiants

DOI: 10.1016/j.autrev.2024.103657 PMID: 39366515
pubmed: 39366515
pii: S1568-9972(24)00148-4
doi: 10.1016/j.autrev.2024.103657
pii:
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

103657

Informations de copyright

Copyright © 2024. Published by Elsevier B.V.

Déclaration de conflit d'intérêts

Declaration of competing interest The authors have no financial or non-financial competing interest to declare.

Auteurs

Tommaso Bucci (T)

Liverpool Centre for Cardiovascular Science, University of Liverpool, Liverpool John Moores University & Liverpool Heart and Chest Hospital, Liverpool, UK; Department of Clinical Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy.

Mira Merashli (M)

Department of Rheumatology, American University of Beirut, Beirut, Lebanon.

Pasquale Pignatelli (P)

Department of Clinical Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy.

Daniele Pastori (D)

Liverpool Centre for Cardiovascular Science, University of Liverpool, Liverpool John Moores University & Liverpool Heart and Chest Hospital, Liverpool, UK; Department of Clinical Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy; IRCCS Neuromed, Localita' Camerelle, Pozzilli, Italy.

Jose' Delgado-Alves (J)

Immune Response & Vascular Disease, iNOVA,4Health, Nova Medical School, Nova University Lisbon, Lisbon, Portugal.

Gregory Y H Lip (GYH)

Liverpool Centre for Cardiovascular Science, University of Liverpool, Liverpool John Moores University & Liverpool Heart and Chest Hospital, Liverpool, UK; Danish Center for Health Services Research, Department of Clinical Medicine, Aalborg University, Denmark.

Paul R J Ames (PRJ)

Immune Response & Vascular Disease, iNOVA,4Health, Nova Medical School, Nova University Lisbon, Lisbon, Portugal; Department of Haematology, Dumfries Royal Infirmary, Cargenbridge, Dumfries, UK. Electronic address: paxmes@aol.com.

Classifications MeSH