Cholesterol promotes

CD4-Positive T-Lymphocytes / metabolism Humans Interferon-gamma / metabolism Cholesterol / metabolism Protein Serine-Threonine Kinases / metabolism Immediate-Early Proteins / metabolism RNA, Messenger / metabolism Memory T Cells / metabolism Male

Journal

Life science alliance
ISSN: 2575-1077
Titre abrégé: Life Sci Alliance
Pays: United States
ID NLM: 101728869

Informations de publication

Date de publication:
Dec 2024
Historique:
received: 18 06 2024
revised: 26 09 2024
accepted: 26 09 2024
medline: 5 10 2024
pubmed: 5 10 2024
entrez: 4 10 2024
Statut: epublish

Résumé

IFNγ-secreting T cells are central for the maintenance of immune surveillance within the central nervous system (CNS). It was previously reported in healthy donors that the T-cell environment in the CNS induces distinct signatures related to cytotoxic capacity, CNS trafficking, tissue adaptation, and lipid homeostasis. These findings suggested that the CNS milieu consisting predominantly of lipids mediated the metabolic conditions leading to IFNγ-secreting brain CD4 T cells. Here, we demonstrate that the supplementation of CD4

Identifiants

DOI: 10.26508/lsa.202402890 PMID: 39366761
pubmed: 39366761
pii: 7/12/e202402890
doi: 10.26508/lsa.202402890
pii:
doi:

Substances chimiques

Interferon-gamma 82115-62-6
Cholesterol 97C5T2UQ7J
Protein Serine-Threonine Kinases EC 2.7.11.1
Immediate-Early Proteins 0
serum-glucocorticoid regulated kinase EC 2.7.11.1
RNA, Messenger 0
IFNG protein, human 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

© 2024 Hanin et al.

Auteurs

Aurélie Hanin (A)

https://ror.org/03v76x132 Departments of Neurology and Immunobiology, Yale University School of Medicine, New Haven, CT, USA.
https://ror.org/050gn5214 Sorbonne Université, Institut du Cerveau-Paris Brain Institute-ICM, Inserm, CNRS, APHP, Hôpital de la Pitié-Salpêtrière, Paris, France.
AP-HP, Epilepsy Unit and Clinical Neurophysiology Department, DMU Neurosciences, Hôpital de la Pitié-Salpêtrière, Paris, France.
ORCID: 0000-0002-5912-9998

Michela Comi (M)

https://ror.org/03v76x132 Departments of Neurology and Immunobiology, Yale University School of Medicine, New Haven, CT, USA.

Tomokazu S Sumida (TS)

https://ror.org/03v76x132 Departments of Neurology and Immunobiology, Yale University School of Medicine, New Haven, CT, USA.

David A Hafler (DA)

https://ror.org/03v76x132 Departments of Neurology and Immunobiology, Yale University School of Medicine, New Haven, CT, USA david.hafler@yale.edu.

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Classifications MeSH

questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Lymphocytes T CD4+ › Cholesterol promotes
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Cholesterol promotes
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Lymphokines › Facteurs d'activation des macrophages › Interféron gamma › Cholesterol promotes
questionsmedicales.fr › Lipides › Lipides membranaires › Stérols › Cholestérol › Cholesterol promotes
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › Cholesterol promotes
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines virales › Protéines virales régulatrices ou accessoires › Protéines précoces immédiates › Cholesterol promotes
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN messager › Cholesterol promotes
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Sous-populations de lymphocytes T › Cellules T mémoire › Cholesterol promotes