Biogenesis and reformation of synaptic vesicles.
active zone
axonal transport
endocytosis
kinesin
neurotransmission
phosphoinositides
synapse
synaptic vesicle
vesicle budding
Journal
The Journal of physiology
ISSN: 1469-7793
Titre abrégé: J Physiol
Pays: England
ID NLM: 0266262
Informations de publication
Date de publication:
05 Oct 2024
05 Oct 2024
Historique:
received:
28
06
2024
accepted:
12
09
2024
medline:
6
10
2024
pubmed:
6
10
2024
entrez:
5
10
2024
Statut:
aheadofprint
Résumé
Communication within the nervous system relies on the calcium-triggered release of neurotransmitter molecules by exocytosis of synaptic vesicles (SVs) at defined active zone release sites. While decades of research have provided detailed insight into the molecular machinery for SV fusion, much less is known about the mechanisms that form functional SVs during the development of synapses and that control local SV reformation following exocytosis in the mature nervous system. Here we review the current state of knowledge in the field, focusing on the pathways implicated in the formation and axonal transport of SV precursor organelles and the mechanisms involved in the local reformation of SVs within nerve terminals in mature neurons. We discuss open questions and outline perspectives for future research.
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : EC | ERC | HORIZON EUROPE European Research Council (ERC)
ID : ERC Advanced Grant 884281 "SynapseBuild"
Organisme : Deutsche Forschungsgemeinschaft (DFG)
ID : HA2686/19-1 (NeuroNex2,#436260754)
Organisme : Deutsche Forschungsgemeinschaftgemeinschaft
ID : TRR186/ A08 (#278001972)
Organisme : Deutsche Forschungsgemeinschaftgemeinschaft
ID : HA2686/22-1 (FOR5228,#447288260)
Organisme : Deutsche Forschungsgemeinschaftgemeinschaft
ID : EXC 2049 (#390688087)
Informations de copyright
© 2024 The Author(s). The Journal of Physiology published by John Wiley & Sons Ltd on behalf of The Physiological Society.
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