Eldecalcitol ameliorates diabetic osteoporosis and glucolipid metabolic disorder by promoting Treg cell differentiation through SOCE.
Animals
T-Lymphocytes, Regulatory
/ drug effects
Cell Differentiation
/ drug effects
Osteoporosis
/ drug therapy
Mice
Diabetes Mellitus, Type 2
/ metabolism
Vitamin D
/ analogs & derivatives
Mice, Inbred C57BL
Stromal Interaction Molecule 1
/ metabolism
Male
ORAI1 Protein
/ metabolism
Calcium
/ metabolism
Diabetes Mellitus, Experimental
/ metabolism
Glycolipids
/ pharmacology
Diabetic osteoporosis
Eldecalcitol
Glucolipid metabolism disorder
Store-operated calcium entry
Treg
Journal
Cellular and molecular life sciences : CMLS
ISSN: 1420-9071
Titre abrégé: Cell Mol Life Sci
Pays: Switzerland
ID NLM: 9705402
Informations de publication
Date de publication:
05 Oct 2024
05 Oct 2024
Historique:
received:
05
06
2024
accepted:
17
09
2024
revised:
27
08
2024
medline:
6
10
2024
pubmed:
6
10
2024
entrez:
5
10
2024
Statut:
epublish
Résumé
Active vitamin D, known for its role in promoting osteoporosis, has immunomodulatory effects according to the latest evidence. Eldecalcitol (ED-71) is a representative of the third-generation novel active vitamin D analogs, and its specific immunological mechanisms in ameliorating diabetic osteoporosis remain unclear. We herein evaluated the therapeutic effects of ED-71 in the context of type 2 diabetes mellitus (T2DM), delving into its underlying mechanisms. In a T2DM mouse model, ED-71 attenuated bone loss and marrow adiposity. Simultaneously, it rectified imbalanced glucose homeostasis and dyslipidemia, ameliorated pancreatic β-cell damage and hepatic glycolipid metabolism disorder. Subsequently, in mice injected with the Treg cell-depleting agent CD25, we observed that the beneficial effects of ED-71 mentioned earlier were partially contingent on the Treg subsets ratio. Mechanistically, ED-71 promoted the differentiation of CD4
Identifiants
pubmed: 39367914
doi: 10.1007/s00018-024-05453-3
pii: 10.1007/s00018-024-05453-3
doi:
Substances chimiques
eldecalcitol
I2JP8UE90H
Vitamin D
1406-16-2
Stromal Interaction Molecule 1
0
ORAI1 Protein
0
Calcium
SY7Q814VUP
Stim1 protein, mouse
0
Orai1 protein, mouse
0
Glycolipids
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
423Subventions
Organisme : National Natural Science Foundation of China
ID : 81972072
Organisme : National Natural Science Foundation of China
ID : 81800982
Organisme : Taishan Scholar Foundation of Shandong Province
ID : tstp20221160
Organisme : Taishan Scholar Foundation of Shandong Province
ID : tsqn202103177
Organisme : Natural Science Foundation of Shandong Province
ID : ZR202210210042
Organisme : Natural Science Foundation of Shandong Province
ID : ZR2020MH184
Informations de copyright
© 2024. The Author(s).
Références
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