Morphology of the normative human cone photoreceptor mosaic and a publicly available adaptive optics montage repository.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
05 Oct 2024
05 Oct 2024
Historique:
received:
02
04
2024
accepted:
24
09
2024
medline:
6
10
2024
pubmed:
6
10
2024
entrez:
5
10
2024
Statut:
epublish
Résumé
Adaptive optics ophthalmoscopy has enabled visualization of the in vivo human photoreceptor mosaic in health, disease and its treatment. Despite this, the clinical utility of the imaging technology has been limited by a lack of automated analysis techniques capable of accurately quantifying photoreceptor structure and a lack of an available normative image database. Here, we present a fully automated algorithm for estimating cone spacing and density over a complete adaptive optics montage along with a database of normative images and cone densities. We imaged the cone mosaics surrounding the fovea and along the horizontal and vertical meridians of fifty normal-sighted controls with a custom-built, multimodal adaptive optics scanning light ophthalmoscope. Cone spacing was automatically measured in the frequency domain and spacing measurements were converted to estimates of cone density at all locations across the montage. Consistent with previous reports, cone density measurements were highest near fovea (152,906 ± 53,209 cones/mm
Identifiants
pubmed: 39369063
doi: 10.1038/s41598-024-74274-y
pii: 10.1038/s41598-024-74274-y
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
23166Subventions
Organisme : NIH HHS
ID : U01EY025864
Pays : United States
Organisme : NIH HHS
ID : NIH R01EY028601, R01EY030227, P30EY001583
Pays : United States
Organisme : Foundation Fighting Blindness
ID : BR-CL-0619-0768-UPA
Pays : United States
Organisme : F. M. Kirby Foundation
ID : no grant number
Organisme : Research to Prevent Blindness
ID : no grant number
Informations de copyright
© 2024. The Author(s).
Références
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