Interferon regulatory factor 7 alleviates the experimental colitis through enhancing IL-28A-mediated intestinal epithelial integrity.
Colitis
Epithelial barrier
IL-28A
IRF7
Interferon
Journal
Journal of translational medicine
ISSN: 1479-5876
Titre abrégé: J Transl Med
Pays: England
ID NLM: 101190741
Informations de publication
Date de publication:
06 Oct 2024
06 Oct 2024
Historique:
received:
02
03
2024
accepted:
02
09
2024
medline:
7
10
2024
pubmed:
7
10
2024
entrez:
6
10
2024
Statut:
epublish
Résumé
The incidence of inflammatory bowel disease (IBD) is on the rise in developing countries, and investigating the underlying mechanisms of IBD is essential for the development of targeted therapeutic interventions. Interferon regulatory factor 7 (IRF7) is known to exert pro-inflammatory effects in various autoimmune diseases, yet its precise role in the development of colitis remains unclear. We analyzed the clinical significance of IRF7 in ulcerative colitis (UC) by searching RNA-Seq databases and collecting tissue samples from clinical UC patients. And, we performed dextran sodium sulfate (DSS)-induced colitis modeling using WT and Irf7 In this study, we found that IRF7 expression is significantly reduced in patients with UC, and also demonstrated that Irf7 These findings underscore the pivotal role of IRF7 in preserving intestinal homeostasis and forestalling the onset of colitis.
Sections du résumé
BACKGROUND
BACKGROUND
The incidence of inflammatory bowel disease (IBD) is on the rise in developing countries, and investigating the underlying mechanisms of IBD is essential for the development of targeted therapeutic interventions. Interferon regulatory factor 7 (IRF7) is known to exert pro-inflammatory effects in various autoimmune diseases, yet its precise role in the development of colitis remains unclear.
METHODS
METHODS
We analyzed the clinical significance of IRF7 in ulcerative colitis (UC) by searching RNA-Seq databases and collecting tissue samples from clinical UC patients. And, we performed dextran sodium sulfate (DSS)-induced colitis modeling using WT and Irf7
RESULTS
RESULTS
In this study, we found that IRF7 expression is significantly reduced in patients with UC, and also demonstrated that Irf7
CONCLUSION
CONCLUSIONS
These findings underscore the pivotal role of IRF7 in preserving intestinal homeostasis and forestalling the onset of colitis.
Identifiants
pubmed: 39370517
doi: 10.1186/s12967-024-05673-y
pii: 10.1186/s12967-024-05673-y
doi:
Substances chimiques
Interferon Regulatory Factor-7
0
Dextran Sulfate
9042-14-2
interferon-lambda protein, mouse
0
Interleukins
0
Cytokines
0
Interferon Lambda
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
905Subventions
Organisme : National Natural Science Foundation of China
ID : 31960163
Organisme : The Jinggang Scholar Program of Jiangxi Province
ID : QD202205
Organisme : The Scientific and Technological Innovation Team Project and Key Project of Cardiocerebrovascular Disease of Gannan Medical University
ID : TD2021JC01
Organisme : The Scientific and Technological Innovation Team Project and Key Project of Cardiocerebrovascular Disease of Gannan Medical University
ID : XN201906
Organisme : Science and Technology Planning Project of Jiangxi Provincial Health Commission
ID : SKJP_220210670
Organisme : the program of Guangdong Provincial Clinical Research Center for Digestive Diseases
ID : 2020B1111170004
Informations de copyright
© 2024. The Author(s).
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