The epithelial barrier theory and its associated diseases.

epidemiology epithelial barrier epithelial barrier dysfunction inflammation microbial dysbiosis

Journal

Allergy
ISSN: 1398-9995
Titre abrégé: Allergy
Pays: Denmark
ID NLM: 7804028

Informations de publication

Date de publication:
07 Oct 2024
Historique:
revised: 28 08 2024
received: 17 05 2024
accepted: 03 09 2024
medline: 7 10 2024
pubmed: 7 10 2024
entrez: 7 10 2024
Statut: aheadofprint

Résumé

The prevalence of many chronic noncommunicable diseases has been steadily rising over the past six decades. During this time, over 350,000 new chemical substances have been introduced to the lives of humans. In recent years, the epithelial barrier theory came to light explaining the growing prevalence and exacerbations of these diseases worldwide. It attributes their onset to a functionally impaired epithelial barrier triggered by the toxicity of the exposed substances, associated with microbial dysbiosis, immune system activation, and inflammation. Diseases encompassed by the epithelial barrier theory share common features such as an increased prevalence after the 1960s or 2000s that cannot (solely) be accounted for by the emergence of improved diagnostic methods. Other common traits include epithelial barrier defects, microbial dysbiosis with loss of commensals and colonization of opportunistic pathogens, and circulating inflammatory cells and cytokines. In addition, practically unrelated diseases that fulfill these criteria have started to emerge as multimorbidities during the last decades. Here, we provide a comprehensive overview of diseases encompassed by the epithelial barrier theory and discuss evidence and similarities for their epidemiology, genetic susceptibility, epithelial barrier dysfunction, microbial dysbiosis, and tissue inflammation.

Identifiants

DOI: 10.1111/all.16318 PMID: 39370939
pubmed: 39370939
doi: 10.1111/all.16318
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

© 2024 The Author(s). Allergy published by European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd.

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Auteurs

Na Sun (N)

Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland.
SKL of Marine Food Processing & Safety Control, National Engineering Research Center of Seafood, School of Food Science and Technology, Dalian Polytechnic University, Dalian, P. R. China.
ORCID: 0000-0001-9936-6907

Ismail Ogulur (I)

Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland.
ORCID: 0000-0001-8282-7762

Yasutaka Mitamura (Y)

Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland.
ORCID: 0000-0001-6389-9285

Duygu Yazici (D)

Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland.
ORCID: 0000-0001-9094-6542

Yagiz Pat (Y)

Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland.
ORCID: 0000-0003-4268-4933

Xiangting Bu (X)

Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland.

Manru Li (M)

Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland.

Xueyi Zhu (X)

Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland.

Huseyn Babayev (H)

Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland.
ORCID: 0000-0001-6985-9436

Sena Ardicli (S)

Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland.
Department of Genetics, Faculty of Veterinary Medicine, Bursa Uludag University, Bursa, Turkey.
ORCID: 0000-0003-2758-5945

Ozge Ardicli (O)

Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland.
Division of Food Processing, Milk and Dairy Products Technology Program, Karacabey Vocational School, Bursa Uludag University, Bursa, Turkey.
ORCID: 0000-0001-6077-0478

Paolo D'Avino (P)

Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland.

Ayca Kiykim (A)

Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland.
Department of Pediatrics, Division of Pediatric Allergy and Immunology, Cerrahpasa School of Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey.
ORCID: 0000-0001-5821-3963

Milena Sokolowska (M)

Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland.
ORCID: 0000-0001-9710-6685

Willem van de Veen (W)

Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland.

Lukas Weidmann (L)

Department of Nephrology, University Hospital Zurich, Zurich, Switzerland.
ORCID: 0009-0001-4948-0995

Deniz Akdis (D)

Department of Cardiology, University Hospital Zurich, Zurich, Switzerland.
ORCID: 0000-0003-4561-3540

Banu Goker Ozdemir (BG)

Obstetrician and Gynecologist, Nisantasi, Istanbul, Turkey.
ORCID: 0009-0005-5220-0869

Marie Charlotte Brüggen (MC)

Christine Kühne-Center for Allergy Research and Education (CK-CARE), Davos, Switzerland.
Faculty of Medicine, University of Zurich, Zurich, Switzerland.
Department of Dermatology, University Hospital Zurich, Zurich, Switzerland.
ORCID: 0000-0002-8607-6254

Luc Biedermann (L)

Department of Gastroenterology and Hepatology, University Hospital Zurich, Zurich, Switzerland.
ORCID: 0000-0003-0824-4125

Alex Straumann (A)

Department of Gastroenterology and Hepatology, University Hospital Zurich, Zurich, Switzerland.

Andrea Kreienbühl (A)

Department of Gastroenterology and Hepatology, University Hospital Zurich, Zurich, Switzerland.

Emma Guttman-Yassky (E)

Department of Dermatology, and Laboratory of Inflammatory Skin Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
ORCID: 0000-0002-9363-324X

Alexandra F Santos (AF)

Department of Women and Children's Health (Pediatric Allergy), School of Life Course Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK.
Children's Allergy Service, Evelina London Children's Hospital, Guy's and St. Thomas' Hospital, London, UK.
Peter Gorer Department of Immunobiology, School of Immunology and Microbial Sciences, King's College London, London, UK.
ORCID: 0000-0002-7805-1436

Stefano Del Giacco (S)

Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy.
ORCID: 0000-0002-4517-1749

Claudia Traidl-Hoffmann (C)

Environmental Medicine, Faculty of Medicine, University of Augsburg, Augsburg, Germany.
ORCID: 0000-0001-5085-5179

David J Jackson (DJ)

Guy's Severe Asthma Centre, Guy's Hospital, Guy's & St Thomas' NHS Trust, London, UK.
School of Immunology & Microbial Sciences, King's College London, London, UK.
ORCID: 0000-0002-2299-868X

De-Yun Wang (DY)

Department of Otolaryngology, Infectious Diseases Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, Singapore City, Singapore.
ORCID: 0000-0002-0909-2963

Antti Lauerma (A)

Department of Dermatology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
ORCID: 0000-0002-5078-3547

Heimo Breiteneder (H)

Department of Pathophysiology and Allergy Research, Medical University of Vienna, Vienna, Austria.
ORCID: 0000-0003-2022-8689

Luo Zhang (L)

Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Beijing Laboratory of Allergic Diseases and Beijing Key Laboratory of Nasal Diseases, Beijing Institute of Otolaryngology, Beijing, China.
ORCID: 0000-0002-0910-9884

Liam O'Mahony (L)

Department of Medicine and School of Microbiology, University College Cork, Cork, Ireland.
APC Microbiome Ireland, Cork, Ireland.
ORCID: 0000-0003-4705-3583

Oliver Pfaar (O)

Department of Otorhinolaryngology, Head and Neck Surgery, Section of Rhinology and Allergy, University Hospital Marburg, Philipps-Universität Marburg, Marburg, Germany.
ORCID: 0000-0003-4374-9639

Robyn O'Hehir (R)

Allergy, Asthma & Clinical Immunology, The Alfred Hospital, Melbourne, Victoria, Australia.
Department of Immunology, School of Translational Medicine, Monash University, Melbourne, Victoria, Australia.
ORCID: 0000-0002-3489-7595

Thomas Eiwegger (T)

Translational Medicine Program, Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada.
Department of Immunology, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
Karl Landsteiner University of Health Sciences, Krems an der Donau, Austria.
Department of Pediatric and Adolescent Medicine, University Hospital St. Pölten, St. Pölten, Austria.

Wytske J Fokkens (WJ)

Department of Otorhinolaryngology & Head and Neck Surgery, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
ORCID: 0000-0003-4852-229X

Beatriz Cabanillas (B)

Department of Allergy, Instituto de Investigación Biosanitaria Hospital 12 de Octubre (imas12), Madrid, Spain.
ORCID: 0000-0002-5351-8140

Cevdet Ozdemir (C)

Department of Pediatric Basic Sciences, Institute of Child Health, Istanbul University, Istanbul, Turkey.
Istanbul Faculty of Medicine, Department of Pediatrics, Division of Pediatric Allergy and Immunology, Istanbul University, Istanbul, Turkey.
ORCID: 0000-0002-9284-4520

Kistler Walter (K)

Department of Sports Medicine, Davos Hospital, Davos, Switzerland.
Swiss Research Institute for Sports Medicine (SRISM), Davos, Switzerland.
Medical Committee International Ice Hockey Federation (IIHF), Zurich, Switzerland.
ORCID: 0000-0002-9289-6953

Mahmut Bayik (M)

Department of Internal Medicine and Hematology, Marmara University, Istanbul, Turkey.
ORCID: 0000-0003-3185-8520

Kari C Nadeau (KC)

Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
ORCID: 0000-0002-2146-2955

Maria J Torres (MJ)

Allergy Unit, IBIMA-Hospital Regional Universitario de Málaga-ARADyAL, UMA, Málaga, Spain.
ORCID: 0000-0001-5228-471X

Mübeccel Akdis (M)

Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland.
ORCID: 0000-0003-0554-9943

Marek Jutel (M)

Department of Clinical Immunology, Wrocław Medical University, Wroclaw, Poland.

Ioana Agache (I)

Faculty of Medicine, Department of Allergy and Clinical Immunology, Transylvania University, Brasov, Romania.
ORCID: 0000-0001-7994-364X

Cezmi A Akdis (CA)

Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland.
ORCID: 0000-0001-8020-019X

Classifications MeSH