Diverse functions of DEAD-box proteins in oligodendrocyte development, differentiation, and homeostasis.

DEAD‐box protein RNA metabolism myelin neural stem cell oligodendrocyte

Journal

Journal of neurochemistry

ISSN: 1471-4159

Titre abrégé: J Neurochem

Pays: England

ID NLM: 2985190R

Informations de publication

Date de publication:
07 Oct 2024

Historique:

revised: 18 09 2024

received: 30 05 2024

accepted: 23 09 2024

medline: 7 10 2024

pubmed: 7 10 2024

entrez: 7 10 2024

Statut: aheadofprint

Résumé

Oligodendrocytes, a type of glial cell in the central nervous system, have a critical role in the formation of myelin around axons, facilitating saltatory conduction, and maintaining the integrity of nerve axons. The dysregulation of oligodendrocyte differentiation and homeostasis have been implicated in a wide range of neurological diseases, including dysmyelinating disorders (e.g., Pelizaeus-Merzbacher disease), demyelinating diseases (e.g., multiple sclerosis), Alzheimer's disease, and psychiatric disorders. Therefore, unraveling the mechanisms of oligodendrocyte development, differentiation, and homeostasis is essential for understanding the pathogenesis of these diseases and the development of therapeutic interventions. Numerous studies have identified and analyzed the functions of transcription factors, RNA metabolic factors, translation control factors, and intracellular and extracellular signals involved in the series of processes from oligodendrocyte fate determination to terminal differentiation. DEAD-box proteins, multifunctional RNA helicases that regulate various intracellular processes, including transcription, RNA processing, and translation, are increasingly recognized for their diverse roles in various aspects of oligodendrocyte development, differentiation, and maintenance of homeostasis. This review introduces the latest insights into the regulatory networks of oligodendrocyte biology mediated by DEAD-box proteins.

Identifiants

DOI: 10.1111/jnc.16238 PMID: 39374171

pubmed: 39374171

doi: 10.1111/jnc.16238

doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

Subventions

Organisme : Grant-in-Aid for Scientific Research (B)

ID : 21H02652

Organisme : Ono Medical Research Foundation

Organisme : Niigata University Interdisciplinary Research U-go grant, 2023

Organisme : Grant-in-Aid for Scientific Research (C)

ID : 23K06300

Informations de copyright

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