Circadian clock dysregulation: a potential mechanism of depression in obstructive sleep apnea patients.
Humans
Sleep Apnea, Obstructive
/ genetics
Male
Middle Aged
Female
Circadian Clocks
/ genetics
Depression
/ genetics
Adult
Polysomnography
CLOCK Proteins
/ genetics
Severity of Illness Index
Circadian Rhythm
/ genetics
Basic Helix-Loop-Helix Transcription Factors
/ genetics
Nerve Tissue Proteins
ARNTL Transcription Factors
Cryptochromes
Journal
Translational psychiatry
ISSN: 2158-3188
Titre abrégé: Transl Psychiatry
Pays: United States
ID NLM: 101562664
Informations de publication
Date de publication:
07 Oct 2024
07 Oct 2024
Historique:
received:
03
04
2024
accepted:
25
09
2024
revised:
19
09
2024
medline:
8
10
2024
pubmed:
8
10
2024
entrez:
7
10
2024
Statut:
epublish
Résumé
Obstructive sleep apnea (OSA) is characterized by co-occurrence with affective disorders. Our study aims to investigate the association of circadian clock gene expressions, and the presence and severity of depressive symptoms in OSA patients. The study included 184 individuals, who underwent polysomnography (PSG) and had their peripheral blood collected in the evening before and the morning after the PSG. Patients were divided into two groups: the OSA (apnea-hypopnea index (AHI) > 5) and the control group (AHI < 5). RNA was extracted from peripheral blood leukocytes. Expression levels of the selected genes (BMAL1, CLOCK, PER1, CRY1, NPAS2, and NR1D1) were assessed by qRT-PCR. Questionnaire data was collected in the morning (including the Insomnia Severity Index (ISI), Epworth Sleepiness Scale (ESS), Chronotype Questionnaire (CQ), and Montgomery-Åsberg Depression Rating Scale (MADRS)). The expression of all examined circadian clock genes in OSA patients was upregulated in the morning compared to the evening (except NPAS2). No differences were observed between OSA and control groups at either time point. Additionally, there was a positive correlation between the severity of depressive symptoms (assessed with MADRS) and morning expression of circadian genes in the group of OSA patients. Finally, in multivariable linear regression, ISI score (B = 0.750, p < 0.001), AM score of CQ (B = 0.416, p = 0.007), and morning PER1 gene expression (B = 4.310, p = 0.042) were found to be predictive factors for greater severity of depression symptoms in OSA patients. Dysregulated circadian clock gene expression in OSA patients is linked to depressive symptom severity, suggesting circadian disruption may underlie affective symptoms in OSA.
Identifiants
pubmed: 39375341
doi: 10.1038/s41398-024-03134-0
pii: 10.1038/s41398-024-03134-0
doi:
Substances chimiques
CLOCK Proteins
EC 2.3.1.48
NPAS2 protein, human
0
CLOCK protein, human
EC 2.3.1.48
Basic Helix-Loop-Helix Transcription Factors
0
CRY1 protein, human
0
BMAL1 protein, human
0
Nerve Tissue Proteins
0
ARNTL Transcription Factors
0
Cryptochromes
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
423Subventions
Organisme : Narodowe Centrum Nauki (National Science Centre)
ID : 2018/31/N/NZ5/03931
Informations de copyright
© 2024. The Author(s).
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