Perspectives on obesity imaging: [
Journal
International journal of obesity (2005)
ISSN: 1476-5497
Titre abrégé: Int J Obes (Lond)
Pays: England
ID NLM: 101256108
Informations de publication
Date de publication:
07 Oct 2024
07 Oct 2024
Historique:
received:
07
09
2023
accepted:
26
09
2024
revised:
06
09
2024
medline:
8
10
2024
pubmed:
8
10
2024
entrez:
7
10
2024
Statut:
aheadofprint
Résumé
Estimates suggest that approximatively 25% of the world population will be overweight in 2025. Better understanding of the pathophysiology of obesity will help to develop future therapeutics. Serotonin subtype 6 receptors (5-HT Influence of diet-induced obesity (DIO) in Wistar rats was explored using MRI (whole-body fat) and PET ([ Wistar rats fed with high-fat diet showed higher body fat gain than Wistar control diet rats on MRI. [ This study sheds a new light on the influence of high-fat diet on 5-HT
Sections du résumé
BACKGROUND
BACKGROUND
Estimates suggest that approximatively 25% of the world population will be overweight in 2025. Better understanding of the pathophysiology of obesity will help to develop future therapeutics. Serotonin subtype 6 receptors (5-HT
METHODS
METHODS
Influence of diet-induced obesity (DIO) in Wistar rats was explored using MRI (whole-body fat) and PET ([
RESULTS
RESULTS
Wistar rats fed with high-fat diet showed higher body fat gain than Wistar control diet rats on MRI. [
CONCLUSION
CONCLUSIONS
This study sheds a new light on the influence of high-fat diet on 5-HT
Identifiants
pubmed: 39375529
doi: 10.1038/s41366-024-01644-x
pii: 10.1038/s41366-024-01644-x
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2024. The Author(s).
Références
Calle EE, Thun MJ, Petrelli JM, Rodriguez C, Heath CW. Body-mass index and mortality in a prospective cohort of U.S. adults. N Engl J Med. 1999;341:1097–105. http://www.nejm.org/doi/abs/10.1056/NEJM199910073411501 .
pubmed: 10511607
doi: 10.1056/NEJM199910073411501
Prospective Studies Collaboration. Body-mass index and cause-specific mortality in 900 000 adults: collaborative analyses of 57 prospective studies. Lancet. 2009;373:1083–96. https://linkinghub.elsevier.com/retrieve/pii/S0140673609603184 .
pmcid: 2662372
doi: 10.1016/S0140-6736(09)60318-4
Lauby-Secretan B, Scoccianti C, Loomis D, Grosse Y, Bianchini F, Straif K. Body fatness and cancer—viewpoint of the IARC Working Group. N Engl J Med. 2016;375:794–8. http://www.nejm.org/doi/10.1056/NEJMsr1606602 .
pubmed: 27557308
pmcid: 6754861
doi: 10.1056/NEJMsr1606602
Anstey KJ, Cherbuin N, Budge M, Young J. Body mass index in midlife and late-life as a risk factor for dementia: a meta-analysis of prospective studies. Obes Rev. 2011;12:e426–37.
pubmed: 21348917
doi: 10.1111/j.1467-789X.2010.00825.x
Yumuk V, Tsigos C, Fried M, Schindler K, Busetto L, Micic D, et al. European guidelines for obesity management in adults. Obes Facts. 2015;8:402–24. https://www.karger.com/Article/FullText/442721 .
pubmed: 26641646
pmcid: 5644856
doi: 10.1159/000442721
Galen KA, Horst KW, Serlie MJ. Serotonin, food intake, and obesity. Obes Rev. 2021;22. https://onlinelibrary.wiley.com/doi/10.1111/obr.13210 .
Halford J, Harrold J, Lawton C, Blundell J. Serotonin (5-HT) drugs: effects on appetite expression and use for the treatment of obesity. CDT. 2005;6:201–13. http://www.eurekaselect.com/openurl/content.php?genre=article&issn=1389-4501&volume=6&issue=2&spage=201 .
doi: 10.2174/1389450053174550
European Medicines Agency. Questions and answers: withdrawal marketing authorisation application Belviq (lorcaserin). 30 May 2013. https://www.ema.europa.eu/en/documents/medicine-qa/questions-answers-withdrawal-marketing-authorisation-application-belviq_en.pdf . Accessed 7 Nov 2020
Sharretts J, Galescu O, Gomatam S, Andraca-Carrera E, Hampp C, Yanoff L. Cancer risk associated with Lorcaserin—the FDA’s review of the CAMELLIA-TIMI 61 trial. N Engl J Med. 2020;383:1000–2. http://www.nejm.org/doi/10.1056/NEJMp2003873 .
pubmed: 32905671
doi: 10.1056/NEJMp2003873
Marazziti D, Baroni S, Pirone A, Giannaccini G, Betti L, Schmid L, et al. Distribution of serotonin receptor of type 6 (5-HT
pubmed: 22278721
doi: 10.1007/s11064-011-0684-y
Heal D, Gosden J, Smith S. The 5-HT6 receptor as a target for developing novel antiobesity drugs. Int Rev Neurobiol. 2011:73–109. https://linkinghub.elsevier.com/retrieve/pii/B9780123859020000048 .
Woolley ML, Bentley JC, Sleight AJ, Marsden CA, Fone KCF. A role for 5-ht6 receptors in retention of spatial learning in the Morris water maze. Neuropharmacology. 2001;41:210–9. https://linkinghub.elsevier.com/retrieve/pii/S0028390801000569 .
pubmed: 11489457
doi: 10.1016/S0028-3908(01)00056-9
Svartengren J, Öhman B, Edling N, Svensson M, Fhölenhag K, Axelsson-Lendin P, et al. The serotonin 5-HT6 receptor antagonist BVT.5182 reduces body weight of high fat diet-induced mice. Int J Obes. 2003b;27:1–94.
Perez-García G, Meneses A. Oral administration of the 5-HT6 receptor antagonists SB-357134 and SB-399885 improves memory formation in an autoshaping learning task. Pharm Biochem Behav. 2005;81:673–82.
doi: 10.1016/j.pbb.2005.05.005
Dudek M, Marcinkowska M, Bucki A, Olczyk A, Kołaczkowski M. Idalopirdine—a small molecule antagonist of 5-HT6 with therapeutic potential against obesity. Metab Brain Dis. 2015;30:1487–94. http://link.springer.com/10.1007/s11011-015-9736-3 .
pubmed: 26419385
pmcid: 4642593
doi: 10.1007/s11011-015-9736-3
Lubelska A, Latacz G, Jastrzębska-Więsek M, Kotańska M, Kurczab R, Partyka A, et al. Are the hydantoin-1,3,5-triazine 5-HT6R ligands a hope to a find new procognitive and anti-obesity drug? Considerations based on primary in vivo assays and ADME-Tox profile in vitro. Molecules 2019;24:4472. https://www.mdpi.com/1420-3049/24/24/4472 .
pubmed: 31817628
pmcid: 6943527
doi: 10.3390/molecules24244472
Frassetto A, Zhang J, Lao JZ, White A, Metzger JM, Fong TM, et al. Reduced sensitivity to diet-induced obesity in mice carrying a mutant 5-HT6 receptor. Brain Res. 2008;1236:140–4. https://linkinghub.elsevier.com/retrieve/pii/S0006899308019872 .
pubmed: 18755168
doi: 10.1016/j.brainres.2008.08.012
Tecott LH, Brennan TJ. Serotonin 5-HT6 receptor knockout mouse. US Patent 6060642. 2000. http://www.freepatentsonline.com/6060642.html .
Kotańska M, Lustyk K, Bucki A, Marcinkowska M, Śniecikowska J, Kołaczkowski M. Idalopirdine, a selective 5-HT6 receptor antagonist, reduces food intake and body weight in a model of excessive eating. Metab Brain Dis. 2018;33:733–40.
pubmed: 29297106
pmcid: 5956042
doi: 10.1007/s11011-017-0175-1
Kurczab R, Ali W, Łażewska D, Kotańska M, Jastrzębska-Więsek M, Satała G, et al. Computer-aided studies for novel arylhydantoin 1,3,5-triazine derivatives as 5-HT6 serotonin receptor ligands with antidepressive-like, anxiolytic and antiobesity action in vivo. Molecules 2018;23:2529. http://www.mdpi.com/1420-3049/23/10/2529 .
pubmed: 30282913
pmcid: 6222450
doi: 10.3390/molecules23102529
Becker G, Colomb J, Sgambato-Faure V, Tremblay L, Billard T, Zimmer L. Preclinical evaluation of [18F]2FNQ1P as the first fluorinated serotonin 5-HT6 radioligand for PET imaging. Eur J Nucl Med Mol Imaging. 2015;42:495–502. http://link.springer.com/10.1007/s00259-014-2936-y .
pubmed: 25331460
doi: 10.1007/s00259-014-2936-y
Colomb J, Becker G, Fieux S, Zimmer L, Billard T. Syntheses, radiolabelings, and in vitro evaluations of fluorinated PET radioligands of 5-HT6 serotoninergic receptors. J Med Chem. 2014;57:3884–90. http://pubs.acs.org/doi/10.1021/jm500372e .
pubmed: 24754711
doi: 10.1021/jm500372e
Courault P, Bouvard S, Bouillot C, Bolbos R, Iecker T, Billard T, et al. Influence of obesity on brain 5-HT6 receptor expression: an in-vivo study with the PET radiotracer [18F]2FNQ1P. 2021. https://zenodo.org/record/4700238 .
Guerville M, Leroy A, Sinquin A, Laugerette F, Michalski MC, Boudry G. Western-diet consumption induces alteration of barrier function mechanisms in the ileum that correlates with metabolic endotoxemia in rats. Am J Physiol Endocrinol Metab. 2017;313:E107–20. https://www.physiology.org/doi/10.1152/ajpendo.00372.2016 .
pubmed: 28400412
doi: 10.1152/ajpendo.00372.2016
Kaya M, Ahishali B. Assessment of permeability in barrier type of endothelium in brain using tracers: Evans Blue, sodium fluorescein, and horseradish peroxidase. In: Turksen K, editor. Permeability barrier (Methods in molecular biology, Vol. 763). Totowa, NJ: Humana Press; 2011. pp. 369–82. http://link.springer.com/10.1007/978-1-61779-191-8_25 .
Barrière DA, Magalhães R, Novais A, Marques P, Selingue E, Geffroy F, et al. The SIGMA rat brain templates and atlases for multimodal MRI data analysis and visualization. Nat Commun. 2019;10:5699.
pubmed: 31836716
pmcid: 6911097
doi: 10.1038/s41467-019-13575-7
Marques C, Meireles M, Norberto S, Leite J, Freitas J, Pestana D, et al. High-fat diet-induced obesity rat model: a comparison between Wistar and Sprague-Dawley Rat. Adipocyte. 2016;5:11–21. http://www.tandfonline.com/doi/full/10.1080/21623945.2015.1061723 .
pubmed: 27144092
doi: 10.1080/21623945.2015.1061723
Roberts JC, Reavill C, East SZ, Harrison PJ, Patel S, Routledge C, et al. The distribution of 5-HT6 receptors in rat brain: an autoradiographic binding study using the radiolabelled 5-HT6 receptor antagonist [125I]SB-258585. Brain Res. 2002;934:49–57. https://linkinghub.elsevier.com/retrieve/pii/S0006899302023600 .
pubmed: 11937069
doi: 10.1016/S0006-8993(02)02360-0
Woolley M, Marsden C, Fone K. 5-ht6 receptors. CDTCNSND. 2004;3:59–79. http://www.eurekaselect.com/openurl/content.php?genre=article&issn=1568-007X&volume=3&issue=1&spage=59 .
doi: 10.2174/1568007043482561
Broberger C. Brain regulation of food intake and appetite: molecules and networks. J Intern Med. 2005;258:301–27. https://onlinelibrary.wiley.com/doi/10.1111/j.1365-2796.2005.01553.x .
pubmed: 16164570
doi: 10.1111/j.1365-2796.2005.01553.x
Woods S, Clarke N, Layfield R, Fone K. 5-HT6 receptor agonists and antagonists enhance learning and memory in a conditioned emotion response paradigm by modulation of cholinergic and glutamatergic mechanisms: 5-HT6 receptor effects on associative learning. Br J Pharmacol. 2012;167:436–49. https://onlinelibrary.wiley.com/doi/10.1111/j.1476-5381.2012.02022.x .
pubmed: 22568655
pmcid: 3481049
doi: 10.1111/j.1476-5381.2012.02022.x
Liśkiewicz, Liśkiewicz AD, Marczak D, Przybyła M, Grabowska K, Student S, et al. Obesity-associated deterioration of the hippocampus is partially restored after weight loss. Brain Behav Immun. 2021;96:212–26. https://linkinghub.elsevier.com/retrieve/pii/S0889159121002312 .
pubmed: 34087424
doi: 10.1016/j.bbi.2021.05.030
Lee THY, Yau SY. From obesity to hippocampal neurodegeneration: pathogenesis and non-pharmacological interventions. IJMS 2020;22:201. https://www.mdpi.com/1422-0067/22/1/201 .
pubmed: 33379163
pmcid: 7796248
doi: 10.3390/ijms22010201
Ziauddeen H, Alonso-Alonso M, Hill JO, Kelley M, Khan NA. Obesity and the neurocognitive basis of food reward and the control of intake. Adv Nutr. 2015;6:474–86. https://academic.oup.com/advances/article/6/4/474/4568664 .
pubmed: 26178031
pmcid: 4496739
doi: 10.3945/an.115.008268
da Silva AAM, Oliveira MM, Cavalcante TCF, do Amaral Almeida LC, Cruz PLM, de Souza SL. Undernutrition during pregnancy and lactation increases the number of fos-cells in the reward system in response to a 5-HT6 receptor agonist in male adolescent rats. Int J Food Sci Nutr. 2018;69:488–93. https://www.tandfonline.com/doi/full/10.1080/09637486.2017.1382455 .
pubmed: 28958176
doi: 10.1080/09637486.2017.1382455
Rothemund Y, Preuschhof C, Bohner G, Bauknecht HC, Klingebiel R, Flor H, et al. Differential activation of the dorsal striatum by high-calorie visual food stimuli in obese individuals. NeuroImage. 2007;37:410–21. https://linkinghub.elsevier.com/retrieve/pii/S1053811907004302 .
pubmed: 17566768
doi: 10.1016/j.neuroimage.2007.05.008
Contreras-Rodríguez O, Martín-Pérez C, Vilar-López R, Verdejo-Garcia A. Ventral and dorsal striatum networks in obesity: link to food craving and weight gain. Biol Psychiatry. 2017;81:789–96. https://linkinghub.elsevier.com/retrieve/pii/S000632231500997X .
pubmed: 26809248
doi: 10.1016/j.biopsych.2015.11.020
Haber SN, Knutson B. The reward circuit: linking primate anatomy and human imaging. Neuropsychopharmacology. 2010;35:4–26. http://www.nature.com/articles/npp2009129 .
pubmed: 19812543
doi: 10.1038/npp.2009.129
He Q, Xiao L, Xue G, Wong S, Ames SL, Schembre SM, et al. Poor ability to resist tempting calorie rich food is linked to altered balance between neural systems involved in urge and self-control. Nutr J. 2014;13:92. https://nutritionj.biomedcentral.com/articles/10.1186/1475-2891-13-92 .
pubmed: 25228353
pmcid: 4172871
doi: 10.1186/1475-2891-13-92
Geliebter A, Benson L, Pantazatos SP, Hirsch J, Carnell S. Greater anterior cingulate activation and connectivity in response to visual and auditory high-calorie food cues in binge eating: preliminary findings. Appetite. 2016;96:195–202. https://linkinghub.elsevier.com/retrieve/pii/S019566631500375X .
pubmed: 26275334
doi: 10.1016/j.appet.2015.08.009
Tataranni PA, Gautier JF, Chen K, Uecker A, Bandy D, Salbe AD, et al. Neuroanatomical correlates of hunger and satiation in humans using positron emission tomography. Proc Natl Acad Sci USA. 1999;96:4569–74. https://pnas.org/doi/full/10.1073/pnas.96.8.4569 .
pubmed: 10200303
pmcid: 16373
doi: 10.1073/pnas.96.8.4569
Del Parigi A, Gautier JF, Chen K, Salbe AD, Ravussin E, Reiman E, et al. Neuroimaging and obesity: mapping the brain responses to hunger and satiation in humans using positron emission tomography. Ann N Y Acad Sci. 2002;967:389–97.
pubmed: 12079866
doi: 10.1111/j.1749-6632.2002.tb04294.x
Kurth F, Levitt JG, Phillips OR, Luders E, Woods RP, Mazziotta JC, et al. Relationships between gray matter, body mass index, and waist circumference in healthy adults. Hum Brain Mapp. 2013;34:1737–46. https://onlinelibrary.wiley.com/doi/10.1002/hbm.22021 .
pubmed: 22419507
doi: 10.1002/hbm.22021
Taki Y, Kinomura S, Sato K, Inoue K, Goto R, Okada K, et al. Relationship between body mass index and gray matter volume in 1,428 healthy individuals. Obesity. 2008;16:119–24. https://onlinelibrary.wiley.com/doi/10.1038/oby.2007.4 .
pubmed: 18223623
doi: 10.1038/oby.2007.4
King BM, Kass JM, Cadieux NL, Sam H, Neville KL, Arceneaux ER. Hyperphagia and obesity in female rats with temporal lobe lesions. Physiol Behav. 1993;54:759–65. https://linkinghub.elsevier.com/retrieve/pii/003193849390088W .
pubmed: 8248354
doi: 10.1016/0031-9384(93)90088-W
Helboe L, Egebjerg J, de Jong IEM. Distribution of serotonin receptor 5-HT6 mRNA in rat neuronal subpopulations: a double in situ hybridization study. Neuroscience. 2015;310:442–54. https://linkinghub.elsevier.com/retrieve/pii/S030645221500891X .
pubmed: 26424380
doi: 10.1016/j.neuroscience.2015.09.064
Schwartz MW, Woods SC, Porte D, Seeley RJ, Baskin DG. Central nervous system control of food intake. Nature. 2000;404:661–71. http://www.nature.com/articles/35007534 .
pubmed: 10766253
doi: 10.1038/35007534
Garfield AS, Burke LK, Shaw J, Evans ML, Heisler LK. Distribution of cells responsive to 5-HT6 receptor antagonist-induced hypophagia. Behav Brain Res. 2014;266:201–6. https://linkinghub.elsevier.com/retrieve/pii/S016643281400093X .
pubmed: 24566060
pmcid: 4003350
doi: 10.1016/j.bbr.2014.02.018
Burguera B, Couce ME, Long J, Lamsam J, Laakso K, Jensen MD, et al. The long form of the leptin receptor (OB-Rb) is widely expressed in the human brain. Neuroendocrinology. 2000;71:187–95. https://www.karger.com/Article/FullText/54536 .
pubmed: 10729790
doi: 10.1159/000054536
Schepers J, Gebhardt C, Bracke A, Eiffler I, von Bohlen und Halbach O. Structural and functional consequences in the amygdala of leptin-deficient mice. Cell Tissue Res. 2020;382:421–6. https://link.springer.com/10.1007/s00441-020-03266-x .
pubmed: 32789683
pmcid: 7584530
doi: 10.1007/s00441-020-03266-x
Gérard C, Martres MP, Lefèvre K, Miquel MC, Vergé D, Lanfumey L, et al. Immuno-localization of serotonin 5-HT6 receptor-like material in the rat central nervous system. Brain Res. 1997;746:207–19.
pubmed: 9037500
doi: 10.1016/S0006-8993(96)01224-3
Huang KP, Ronveaux CC, Knotts TA, Rutkowsky JR, Ramsey JJ, Raybould HE. Sex differences in response to short-term high fat diet in mice. Physiol Behav. 2020;221:112894. https://linkinghub.elsevier.com/retrieve/pii/S0031938420302110 .
pubmed: 32259599
pmcid: 7285373
doi: 10.1016/j.physbeh.2020.112894
Voigt JP, Fink H. Serotonin controlling feeding and satiety. Behav Brain Res. 2015;277:14–31.
pubmed: 25217810
doi: 10.1016/j.bbr.2014.08.065
Perry KW, Fuller RW. Effect of fluoxetine on serotonin and dopamine concentration in microdialysis fluid from rat striatum. Life Sci. 1992;50:1683–90. https://linkinghub.elsevier.com/retrieve/pii/002432059290423M .
pubmed: 1375306
doi: 10.1016/0024-3205(92)90423-M
Hirst WD, Abrahamsen B, Blaney FE, Calver AR, Aloj L, Price GW, et al. Differences in the central nervous system distribution and pharmacology of the mouse 5-hydroxytryptamine-6 receptor compared with rat and human receptors investigated by radioligand binding, site-directed mutagenesis, and molecular modeling. Mol Pharm. 2003;64:1295–308. http://molpharm.aspetjournals.org/lookup/doi/10.1124/mol.64.6.1295 .
doi: 10.1124/mol.64.6.1295
Anderberg RH, Richard JE, Eerola K, López-Ferreras L, Banke E, Hansson C, et al. Glucagon-like peptide 1 and its analogs act in the dorsal raphe and modulate central serotonin to reduce appetite and body weight. Diabetes. 2017;66:1062–73. https://diabetesjournals.org/diabetes/article/66/4/1062/16083/Glucagon-Like-Peptide-1-and-Its-Analogs-Act-in-the .
pubmed: 28057699
doi: 10.2337/db16-0755
Kim YK, Kim OY, Song J. Alleviation of depression by glucagon-like peptide 1 through the regulation of neuroinflammation, neurotransmitters, neurogenesis, and synaptic function. Front Pharm. 2020;11:1270. https://www.frontiersin.org/article/10.3389/fphar.2020.01270/full .
doi: 10.3389/fphar.2020.01270